Gene description for COX2
Gene name mitochondrially encoded cytochrome c oxidase II
Gene symbol COX2
Other names/aliases COII
MTCO2
Species Homo sapiens
 Database cross references - COX2
ExoCarta ExoCarta_4513
Vesiclepedia VP_4513
Entrez Gene 4513
HGNC 7421
MIM 516040
UniProt P00403  
 COX2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for COX2
Molecular Function
    cytochrome-c oxidase activity GO:0004129 IBA
    cytochrome-c oxidase activity GO:0004129 IMP
    cytochrome-c oxidase activity GO:0004129 NAS
    copper ion binding GO:0005507 IEA
    protein binding GO:0005515 IPI
Biological Process
    response to hypoxia GO:0001666 IEA
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 ISS
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 NAS
    lactation GO:0007595 IEA
    ATP synthesis coupled electron transport GO:0042773 IBA
    cellular respiration GO:0045333 NAS
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial matrix GO:0005759 TAS
    membrane GO:0016020 HDA
    mitochondrial membrane GO:0031966 IDA
    respiratory chain complex IV GO:0045277 IDA
 Experiment description of studies that identified COX2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDHA1 5160
Co-fractionation Homo sapiens
2 ACOT7 11332
Affinity Capture-MS Homo sapiens
3 LIG4 3981
Two-hybrid Homo sapiens
4 SSR4 6748
Co-fractionation Homo sapiens
5 KLF8  
Affinity Capture-MS Homo sapiens
6 POR 5447
Co-fractionation Homo sapiens
7 NDUFS1 4719
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
8 HINT2 84681
Proximity Label-MS Homo sapiens
9 YWHAE 7531
Two-hybrid Homo sapiens
10 TRUB2  
Proximity Label-MS Homo sapiens
11 NDUFS7 374291
Co-fractionation Homo sapiens
12 VHL  
Two-hybrid Homo sapiens
13 NDUFA4 4697
Co-fractionation Homo sapiens
14 ACTB 60
Co-fractionation Homo sapiens
15 CCDC90B  
Proximity Label-MS Homo sapiens
16 TOMM22 56993
Co-fractionation Homo sapiens
17 KIAA1429 25962
Affinity Capture-MS Homo sapiens
18 NDUFS3 4722
Co-fractionation Homo sapiens
19 OGDH 4967
Co-fractionation Homo sapiens
20 TFAM 7019
Co-fractionation Homo sapiens
21 PMPCA 23203
Proximity Label-MS Homo sapiens
22 SDHB 6390
Co-fractionation Homo sapiens
23 COX7A2L 9167
Co-fractionation Homo sapiens
24 PRC1 9055
Affinity Capture-MS Homo sapiens
25 C8orf82  
Proximity Label-MS Homo sapiens
26 COA3 28958
Affinity Capture-Western Homo sapiens
27 SSR1 6745
Co-fractionation Homo sapiens
28 LONP1 9361
Proximity Label-MS Homo sapiens
29 DDOST 1650
Co-fractionation Homo sapiens
30 HADHA 3030
Co-fractionation Homo sapiens
31 SURF1  
Proximity Label-MS Homo sapiens
32 C20orf24  
Co-fractionation Homo sapiens
33 PPP2R1A 5518
Co-fractionation Homo sapiens
34 NDUFV1 4723
Co-fractionation Homo sapiens
35 PHB 5245
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
36 TOMM40 10452
Co-fractionation Homo sapiens
37 CANX 821
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
38 CALR 811
Co-fractionation Homo sapiens
39 MYCN  
Affinity Capture-MS Homo sapiens
40 PSMA1 5682
Two-hybrid Homo sapiens
41 COX1 4512
Affinity Capture-Western Homo sapiens
42 FAF2 23197
Affinity Capture-MS Homo sapiens
43 UQCRQ 27089
Co-fractionation Homo sapiens
44 SLC25A3 5250
Co-fractionation Homo sapiens
45 RAB1B 81876
Co-fractionation Homo sapiens
46 MDH2 4191
Proximity Label-MS Homo sapiens
47 KLF16  
Affinity Capture-MS Homo sapiens
48 APOO 79135
Proximity Label-MS Homo sapiens
49 COX7A2 1347
Co-fractionation Homo sapiens
50 P4HA1 5033
Co-fractionation Homo sapiens
51 COX15 1355
Proximity Label-MS Homo sapiens
52 ANTXR1 84168
Affinity Capture-MS Homo sapiens
53 PARK2  
Affinity Capture-MS Homo sapiens
54 STOM 2040
Affinity Capture-MS Homo sapiens
55 HRSP12 10247
Two-hybrid Homo sapiens
56 HSP90B1 7184
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
57 DIABLO 56616
Proximity Label-MS Homo sapiens
58 PMAIP1  
Affinity Capture-MS Homo sapiens
59 VCP 7415
Co-fractionation Homo sapiens
60 CCDC109B 55013
Proximity Label-MS Homo sapiens
61 DTX2 113878
Proximity Label-MS Homo sapiens
62 TBRG4 9238
Proximity Label-MS Homo sapiens
63 CYC1 1537
Co-fractionation Homo sapiens
64 UQCRC1 7384
Co-fractionation Homo sapiens
65 RPN1 6184
Co-fractionation Homo sapiens
66 BCL6  
Affinity Capture-MS Homo sapiens
67 COX7B 1349
Co-fractionation Homo sapiens
68 MYL12A 10627
Co-fractionation Homo sapiens
69 TMEM70  
Proximity Label-MS Homo sapiens
70 NIPSNAP1 8508
Co-fractionation Homo sapiens
71 RAD21 5885
Two-hybrid Homo sapiens
72 COX4I1 1327
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
73 COX7A1  
Affinity Capture-MS Homo sapiens
74 COX5B 1329
Co-fractionation Homo sapiens
75 HADHB 3032
Co-fractionation Homo sapiens
76 SLC25A12 8604
Proximity Label-MS Homo sapiens
77 FANCD2  
Affinity Capture-MS Homo sapiens
78 AIFM1 9131
Proximity Label-MS Homo sapiens
79 METTL14  
Affinity Capture-MS Homo sapiens
80 GPD2 2820
Co-fractionation Homo sapiens
81 NDUFA9 4704
Co-fractionation Homo sapiens
82 ECT2 1894
Two-hybrid Homo sapiens
83 NELFCD 51497
Affinity Capture-MS Homo sapiens
84 UQCRC2 7385
Co-fractionation Homo sapiens
85 CTNNB1 1499
Co-fractionation Homo sapiens
86 COX6A1  
Affinity Capture-MS Homo sapiens
87 BCAP31 10134
Co-fractionation Homo sapiens
88 ATP5F1 515
Co-fractionation Homo sapiens
89 RMND1 55005
Proximity Label-MS Homo sapiens
90 EGFR 1956
Affinity Capture-MS Homo sapiens
91 PDPK1 5170
Affinity Capture-Western Homo sapiens
92 RIPK4  
Affinity Capture-MS Homo sapiens
93 FN1 2335
Affinity Capture-MS Homo sapiens
94 ZNF782  
Co-fractionation Homo sapiens
95 CDK2 1017
Affinity Capture-MS Homo sapiens
96 MAPK6  
Affinity Capture-MS Homo sapiens
97 SOAT1 6646
Affinity Capture-MS Homo sapiens
98 CNR2  
Affinity Capture-MS Homo sapiens
99 RPA3 6119
Proximity Label-MS Homo sapiens
100 COX6C 1345
Co-fractionation Homo sapiens
101 ASPH 444
Co-fractionation Homo sapiens
102 PTPRN  
Affinity Capture-MS Homo sapiens
103 ACAD9 28976
Proximity Label-MS Homo sapiens
104 PREB 10113
Co-fractionation Homo sapiens
105 VDAC1 7416
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
106 CLTC 1213
Co-fractionation Homo sapiens
107 AKT1 207
Affinity Capture-Western Homo sapiens
108 TOMM5  
Co-fractionation Homo sapiens
109 NDUFV2 4729
Co-fractionation Homo sapiens
110 CORO1C 23603
Co-fractionation Homo sapiens
111 MAGT1 84061
Co-fractionation Homo sapiens
112 MCUR1 63933
Proximity Label-MS Homo sapiens
113 SCCPDH 51097
Co-fractionation Homo sapiens
114 GBAS 2631
Co-fractionation Homo sapiens
115 ATP2B3 492
Co-fractionation Homo sapiens
116 PHB2 11331
Co-fractionation Homo sapiens
117 COX20  
Affinity Capture-Western Homo sapiens
118 VDAC3 7419
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
119 HSPB2  
Two-hybrid Homo sapiens
120 ICT1 3396
Affinity Capture-MS Homo sapiens
121 ZNF746  
Affinity Capture-MS Homo sapiens
122 NLGN3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
123 BCKDHA 593
Co-fractionation Homo sapiens
124 COX5A 9377
Co-fractionation Homo sapiens
125 Htt  
Affinity Capture-MS Mus musculus
126 PDHB 5162
Co-fractionation Homo sapiens
127 COX8A  
Co-fractionation Homo sapiens
128 C21orf33  
Proximity Label-MS Homo sapiens
129 GORASP1 64689
Affinity Capture-MS Homo sapiens
130 SMDT1  
Co-fractionation Homo sapiens
131 SFXN1 94081
Proximity Label-MS Homo sapiens
132 VDAC2 7417
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
133 NDUFS8 4728
Co-fractionation Homo sapiens
134 BCL2L13 23786
Co-fractionation Homo sapiens
135 GFM1 85476
Proximity Label-MS Homo sapiens
136 ATP5B 506
Co-fractionation Homo sapiens
137 SLC25A51  
Proximity Label-MS Homo sapiens
138 RPUSD3  
Proximity Label-MS Homo sapiens
139 MCU 90550
Proximity Label-MS Homo sapiens
140 C1QBP 708
Proximity Label-MS Homo sapiens
141 CUL7 9820
Affinity Capture-MS Homo sapiens
142 ATP5C1 509
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
143 COX7C 1350
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
144 C9orf72  
Affinity Capture-MS Homo sapiens
145 METTL17  
Proximity Label-MS Homo sapiens
146 MGST3 4259
Co-fractionation Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here