Gene description for TMOD3
Gene name tropomodulin 3 (ubiquitous)
Gene symbol TMOD3
Other names/aliases UTMOD
Species Homo sapiens
 Database cross references - TMOD3
ExoCarta ExoCarta_29766
Entrez Gene 29766
HGNC 11873
MIM 605112
UniProt Q9NYL9  
 TMOD3 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TMOD3
Molecular Function
    actin binding GO:0003779 IEA
    tropomyosin binding GO:0005523 IEA
Biological Process
    erythrocyte development GO:0048821 IEA
    pointed-end actin filament capping GO:0051694 IEA
    positive regulation of mitotic cell cycle phase transition GO:1901992 IEA
    actin filament organization GO:0007015 IBA
    myofibril assembly GO:0030239 IBA
    muscle contraction GO:0006936 IBA
Subcellular Localization
    striated muscle thin filament GO:0005865 IBA
    myofibril GO:0030016 IBA
    cytoskeleton GO:0005856 IBA
 Experiment description of studies that identified TMOD3 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TMOD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TMOD3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here