Gene description for CALR
Gene name	calreticulin
Gene symbol	CALR
Other names/aliases	CRT HEL-S-99n RO SSA cC1qR
Species	Homo sapiens
Database cross references - CALR
ExoCarta	ExoCarta_811
Entrez Gene	811
HGNC	1455
MIM	109091
UniProt	P27797
CALR identified in exosomes derived from the following tissue/cell type
Bladder cancer cells	20224111
Keratinocytes	19530224
Keratinocytes	19530224
Melanoma cells	25950383
Melanoma cells	25950383
Mesenchymal stem cells	Unpublished / Not applicable
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Prostate cancer cells	22723089
Prostate cancer cells	22723089
Saliva	19199708
Thymus	23844026
Urine	15326289

Gene ontology annotations for CALR

Molecular Function     unfolded protein binding GO:0051082 TAS     poly(A) RNA binding GO:0044822 IDA     androgen receptor binding GO:0050681 IDA     carbohydrate binding GO:0030246 TAS     calcium ion binding GO:0005509 TAS     integrin binding GO:0005178 IPI     mRNA binding GO:0003729 IDA     hormone binding GO:0042562 IEA     chaperone binding GO:0051087 TAS     protein binding GO:0005515 IPI     ubiquitin protein ligase binding GO:0031625 IPI     DNA binding GO:0003677 NAS     peptide binding GO:0042277 IEA     glycoprotein binding GO:0001948 IPI     protein binding involved in protein folding GO:0044183 TAS     iron ion binding GO:0005506 IEA     complement component C1q binding GO:0001849 TAS     zinc ion binding GO:0008270 TAS Biological Process     negative regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 IDA     protein maturation by protein folding GO:0022417 TAS     receptor-mediated endocytosis GO:0006898 TAS     positive regulation of DNA replication GO:0045740 IGI     antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS     post-translational protein modification GO:0043687 TAS     response to testosterone GO:0033574 IEA     sequestering of calcium ion GO:0051208 TAS     positive regulation of cell proliferation GO:0008284 IGI     protein export from nucleus GO:0006611 IDA     cellular senescence GO:0090398 IGI     protein stabilization GO:0050821 TAS     negative regulation of neuron differentiation GO:0045665 IDA     protein folding GO:0006457 TAS     negative regulation of retinoic acid receptor signaling pathway GO:0048387 IDA     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IMP     peptide antigen assembly with MHC class I protein complex GO:0002502 ISS     response to drug GO:0042493 IEA     ATF6-mediated unfolded protein response GO:0036500 TAS     cortical actin cytoskeleton organization GO:0030866 IEA     negative regulation of translation GO:0017148 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA     protein localization to nucleus GO:0034504 IDA     protein folding in endoplasmic reticulum GO:0034975 TAS     antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 TAS     positive regulation of phagocytosis GO:0050766 ISS     protein N-linked glycosylation via asparagine GO:0018279 TAS     positive regulation of dendritic cell chemotaxis GO:2000510 IMP     regulation of meiotic nuclear division GO:0040020 IEA     cellular calcium ion homeostasis GO:0006874 TAS     cellular protein metabolic process GO:0044267 TAS     response to estradiol GO:0032355 IEA     glucocorticoid receptor signaling pathway GO:0042921 TAS     endoplasmic reticulum unfolded protein response GO:0030968 TAS     regulation of transcription, DNA-templated GO:0006355 TAS     antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS     positive regulation of cell cycle GO:0045787 IGI     negative regulation of transcription, DNA-templated GO:0045892 IDA     cardiac muscle cell differentiation GO:0055007 IEA     regulation of apoptotic process GO:0042981 TAS     cell cycle arrest GO:0007050 IGI     spermatogenesis GO:0007283 IEA     cellular response to lithium ion GO:0071285 IEA     chaperone-mediated protein folding GO:0061077 IEA     positive regulation of gene expression GO:0010628 IEA Subcellular Localization     proteinaceous extracellular matrix GO:0005578 IEA     cytosol GO:0005829 IDA     external side of plasma membrane GO:0009897 IEA     Golgi apparatus GO:0005794 IEA     acrosomal vesicle GO:0001669 IEA     endoplasmic reticulum lumen GO:0005788 TAS     cytoplasm GO:0005737 IDA     perinuclear region of cytoplasm GO:0048471 IDA     extracellular exosome GO:0070062 IDA     polysome GO:0005844 ISS     sarcoplasmic reticulum lumen GO:0033018 IEA     membrane GO:0016020 IDA     cell surface GO:0009986 TAS     focal adhesion GO:0005925 IDA     endoplasmic reticulum GO:0005783 TAS     extracellular space GO:0005615 IDA     integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 TAS     intracellular GO:0005622 TAS     extracellular region GO:0005576 TAS     MHC class I peptide loading complex GO:0042824 ISS     nucleus GO:0005634 IDA     smooth endoplasmic reticulum GO:0005790 IEA     endocytic vesicle lumen GO:0071682 TAS