Gene description for APP
Gene name	amyloid beta (A4) precursor protein
Gene symbol	APP
Other names/aliases	AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2
Species	Homo sapiens
Database cross references - APP
ExoCarta	ExoCarta_351
Entrez Gene	351
HGNC	620
MIM	104760
UniProt	P05067
APP identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Hepatocellular carcinoma cells	26054723
Keratinocytes	19530224
Keratinocytes	19530224
Mesenchymal stem cells	Unpublished / Not applicable
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Prostate cancer cells	22723089
Prostate cancer cells	22723089
Prostate cancer cells	22723089
Prostate cancer cells	25857301
Prostate cancer cells	25844599
Prostate cancer cells	25844599
Saliva	19199708

Gene ontology annotations for APP

Molecular Function     protein binding GO:0005515 IPI     serine-type endopeptidase inhibitor activity GO:0004867 IDA     DNA binding GO:0003677 ISS     transition metal ion binding GO:0046914 IEA     peptidase activator activity GO:0016504 IEA     acetylcholine receptor binding GO:0033130 IPI     enzyme binding GO:0019899 IPI     growth factor receptor binding GO:0070851 IEA     heparin binding GO:0008201 IEA     identical protein binding GO:0042802 IPI     PTB domain binding GO:0051425 IPI     receptor binding GO:0005102 IPI Biological Process     mRNA polyadenylation GO:0006378 ISS     protein phosphorylation GO:0006468 ISS     response to oxidative stress GO:0006979 IEA     neuron apoptotic process GO:0051402 IMP     forebrain development GO:0030900 IEA     regulation of multicellular organism growth GO:0040014 ISS     regulation of epidermal growth factor-activated receptor activity GO:0007176 ISS     axon cargo transport GO:0008088 ISS     visual learning GO:0008542 ISS     platelet activation GO:0030168 TAS     regulation of synapse structure or activity GO:0050803 ISS     negative regulation of endopeptidase activity GO:0010951 IEA     neuron projection development GO:0031175 ISS     positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IEA     cell adhesion GO:0007155 IEA     negative regulation of neuron differentiation GO:0045665 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     adult locomotory behavior GO:0008344 ISS     Notch signaling pathway GO:0007219 IEA     collateral sprouting in absence of injury GO:0048669 ISS     blood coagulation GO:0007596 TAS     cellular copper ion homeostasis GO:0006878 ISS     mating behavior GO:0007617 ISS     membrane organization GO:0061024 TAS     endocytosis GO:0006897 ISS     regulation of translation GO:0006417 ISS     locomotory behavior GO:0007626 ISS     dendrite development GO:0016358 ISS     axonogenesis GO:0007409 ISS     cholesterol metabolic process GO:0008203 IEA     regulation of protein binding GO:0043393 IEA     platelet degranulation GO:0002576 TAS     synaptic growth at neuromuscular junction GO:0051124 IEA     post-Golgi vesicle-mediated transport GO:0006892 TAS     neuromuscular process controlling balance GO:0050885 IEA     positive regulation of peptidase activity GO:0010952 IEA     suckling behavior GO:0001967 IEA     innate immune response GO:0045087 TAS     extracellular matrix organization GO:0030198 TAS     axon midline choice point recognition GO:0016199 ISS     smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 IEA     ionotropic glutamate receptor signaling pathway GO:0035235 ISS     nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS     positive regulation of mitotic cell cycle GO:0045931 ISS     neuron remodeling GO:0016322 ISS Subcellular Localization     platelet alpha granule lumen GO:0031093 TAS     synapse GO:0045202 IDA     plasma membrane GO:0005886 IDA     ciliary rootlet GO:0035253 IEA     extracellular region GO:0005576 TAS     apical part of cell GO:0045177 IEA     perinuclear region of cytoplasm GO:0048471 IDA     extracellular space GO:0005615 IDA     receptor complex GO:0043235 IDA     dendritic shaft GO:0043198 IDA     endosome GO:0005768 IDA     cytoplasm GO:0005737 ISS     extracellular exosome GO:0070062 IDA     cell surface GO:0009986 IDA     smooth endoplasmic reticulum GO:0005790 IEA     axon GO:0030424 ISS     intracellular membrane-bounded organelle GO:0043231 IDA     coated pit GO:0005905 IEA     ER to Golgi transport vesicle GO:0030134 IEA     endosome lumen GO:0031904 TAS     cell-cell junction GO:0005911 IEA     Golgi apparatus GO:0005794 ISS     nuclear envelope lumen GO:0005641 IDA     trans-Golgi network membrane GO:0032588 TAS     spindle midzone GO:0051233 IEA     integral component of membrane GO:0016021 ISS     membrane raft GO:0045121 IDA     dendritic spine GO:0043197 IDA     cytosol GO:0005829 TAS     neuromuscular junction GO:0031594 IEA     integral component of plasma membrane GO:0005887 TAS