Gene description for NF2
Gene name neurofibromin 2 (merlin)
Gene symbol NF2
Other names/aliases ACN
BANF
SCH
Species Homo sapiens
 Database cross references - NF2
ExoCarta ExoCarta_4771
Vesiclepedia VP_4771
Entrez Gene 4771
HGNC 7773
MIM 607379
UniProt P35240  
 NF2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NF2
Molecular Function
    actin binding GO:0003779 IBA
    integrin binding GO:0005178 IBA
    protein binding GO:0005515 IPI
Biological Process
    MAPK cascade GO:0000165 IEA
    mesoderm formation GO:0001707 IEA
    negative regulation of cell-matrix adhesion GO:0001953 TAS
    ectoderm development GO:0007398 IEA
    negative regulation of cell population proliferation GO:0008285 IBA
    negative regulation of cell population proliferation GO:0008285 IDA
    negative regulation of cell population proliferation GO:0008285 IMP
    regulation of cell shape GO:0008360 IBA
    negative regulation of Schwann cell proliferation GO:0010626 IEA
    Schwann cell proliferation GO:0014010 IMP
    regulation of gliogenesis GO:0014013 IBA
    hippocampus development GO:0021766 IEA
    negative regulation of cell-cell adhesion GO:0022408 IDA
    actin cytoskeleton organization GO:0030036 IMP
    negative regulation of cell migration GO:0030336 TAS
    regulation of protein stability GO:0031647 IEA
    osteoblast proliferation GO:0033687 IEA
    negative regulation of osteoblast proliferation GO:0033689 IEA
    regulation of hippo signaling GO:0035330 IBA
    regulation of hippo signaling GO:0035330 IMP
    odontogenesis of dentin-containing tooth GO:0042475 IEA
    regulation of apoptotic process GO:0042981 IMP
    negative regulation of MAPK cascade GO:0043409 IEA
    cell-cell junction organization GO:0045216 IEA
    positive regulation of cell differentiation GO:0045597 IEA
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IDA
    positive regulation of stress fiber assembly GO:0051496 IMP
    regulation of cell cycle GO:0051726 IMP
    lens fiber cell differentiation GO:0070306 IEA
    regulation of stem cell proliferation GO:0072091 IEA
    regulation of protein localization to nucleus GO:1900180 IEA
    regulation of organelle assembly GO:1902115 IBA
    positive regulation of protein localization to early endosome GO:1902966 IBA
    regulation of neural precursor cell proliferation GO:2000177 IEA
    positive regulation of early endosome to late endosome transport GO:2000643 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IDA
    early endosome GO:0005769 IDA
    cytosol GO:0005829 IDA
    cytoskeleton GO:0005856 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    adherens junction GO:0005912 IBA
    membrane GO:0016020 HDA
    lamellipodium GO:0030027 IEA
    filopodium GO:0030175 IBA
    cortical actin cytoskeleton GO:0030864 IEA
    filopodium membrane GO:0031527 IEA
    cleavage furrow GO:0032154 IEA
    ruffle membrane GO:0032587 IEA
    neuron projection GO:0043005 IEA
    cell body GO:0044297 IEA
    apical part of cell GO:0045177 IBA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified NF2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
9
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CBS 875
Affinity Capture-MS Homo sapiens
2 TGOLN2 10618
Negative Genetic Homo sapiens
3 MVP 9961
Affinity Capture-MS Homo sapiens
4 PTPRG 5793
Proximity Label-MS Homo sapiens
5 RIT1 6016
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 AFG3L2 10939
Affinity Capture-MS Homo sapiens
7 SMC3 9126
Affinity Capture-MS Homo sapiens
8 RFC1 5981
Affinity Capture-MS Homo sapiens
9 OCLN 100506658
Proximity Label-MS Homo sapiens
10 KSR1  
Affinity Capture-Western Homo sapiens
11 UBE2K 3093
Negative Genetic Homo sapiens
12 MC1R 4157
Affinity Capture-MS Homo sapiens
13 MARCKS 4082
Proximity Label-MS Homo sapiens
14 EIF2S3 1968
Affinity Capture-MS Homo sapiens
15 GJA1 2697
Proximity Label-MS Homo sapiens
16 ACOT9 23597
Negative Genetic Homo sapiens
17 MCM9 254394
Negative Genetic Homo sapiens
18 SH3GL1 6455
Affinity Capture-MS Homo sapiens
19 PARD3 56288
Proximity Label-MS Homo sapiens
20 VPRBP 9730
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
21 RPL13A 23521
Affinity Capture-MS Homo sapiens
22 MTPAP 55149
Affinity Capture-MS Homo sapiens
23 NHLRC2 374354
Affinity Capture-MS Homo sapiens
24 DBN1 1627
Affinity Capture-MS Homo sapiens
25 CD2AP 23607
Affinity Capture-MS Homo sapiens
26 SUPT16H 11198
Affinity Capture-MS Homo sapiens
27 TSG101 7251
Affinity Capture-MS Homo sapiens
28 RPL15 6138
Affinity Capture-MS Homo sapiens
29 KIF20A 10112
Affinity Capture-MS Homo sapiens
30 IGF2BP1 10642
Affinity Capture-MS Homo sapiens
31 SLC25A1 6576
Affinity Capture-MS Homo sapiens
32 LAMP2 3920
Proximity Label-MS Homo sapiens
33 KPNA2 3838
Affinity Capture-MS Homo sapiens
34 CCNB1IP1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
35 GRPEL1 80273
Affinity Capture-MS Homo sapiens
36 SOX2  
Affinity Capture-MS Homo sapiens
37 AKAP8L  
Affinity Capture-MS Homo sapiens
38 DECR1 1666
Affinity Capture-MS Homo sapiens
39 LPCAT1 79888
Affinity Capture-MS Homo sapiens
40 AMOTL1 154810
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
41 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
42 APEX1 328
Affinity Capture-RNA Homo sapiens
43 EGFR 1956
Affinity Capture-Western Homo sapiens
44 XRCC1 7515
Affinity Capture-MS Homo sapiens
45 RPL4 6124
Affinity Capture-MS Homo sapiens
46 RDX 5962
Affinity Capture-MS Homo sapiens
47 CDK5 1020
Affinity Capture-MS Homo sapiens
48 DARS 1615
Affinity Capture-MS Homo sapiens
49 SARS2 54938
Affinity Capture-MS Homo sapiens
50 DYRK2 8445
Negative Genetic Homo sapiens
51 PRPF38B 55119
Affinity Capture-MS Homo sapiens
52 SERPINB3 6317
Affinity Capture-MS Homo sapiens
53 PNKP 11284
Affinity Capture-MS Homo sapiens
54 NIT1 4817
Affinity Capture-MS Homo sapiens
55 EIF3B 8662
Two-hybrid Homo sapiens
56 RFC3 5983
Affinity Capture-MS Homo sapiens
57 HGS 9146
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
58 TAF15 8148
Affinity Capture-MS Homo sapiens
59 SRRM2 23524
Affinity Capture-MS Homo sapiens
60 HSPH1 10808
Affinity Capture-MS Homo sapiens
61 LEMD2 221496
Affinity Capture-MS Homo sapiens
62 MPP2 4355
Affinity Capture-MS Homo sapiens
63 RPS5 6193
Affinity Capture-MS Homo sapiens
64 DYNLL1 8655
Affinity Capture-MS Homo sapiens
65 FANCD2  
Negative Genetic Homo sapiens
66 SFXN2  
Affinity Capture-MS Homo sapiens
67 CKAP5 9793
Affinity Capture-MS Homo sapiens
68 PHB 5245
Affinity Capture-MS Homo sapiens
69 RPS3A 6189
Affinity Capture-MS Homo sapiens
70 SCHIP1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
71 CUL1 8454
Affinity Capture-MS Homo sapiens
72 TFCP2 7024
Affinity Capture-MS Homo sapiens
73 GPS1 2873
Affinity Capture-Western Homo sapiens
74 SDCBP 6386
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
75 TSN 7247
Affinity Capture-MS Homo sapiens
76 ICE2  
Negative Genetic Homo sapiens
77 AMOT  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 NCSTN 23385
Negative Genetic Homo sapiens
79 PABPC4 8761
Affinity Capture-MS Homo sapiens
80 CPNE3 8895
Affinity Capture-MS Homo sapiens
81 ATG5 9474
Affinity Capture-MS Homo sapiens
82 KIF14 9928
Affinity Capture-MS Homo sapiens
83 LSM12 124801
Affinity Capture-MS Homo sapiens
84 DSC1 1823
Affinity Capture-MS Homo sapiens
85 FANCF  
Negative Genetic Homo sapiens
86 XRCC4  
Affinity Capture-MS Homo sapiens
87 AMOTL2 51421
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 NF2 4771
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
89 ATAD3B 83858
Affinity Capture-MS Homo sapiens
90 IRS4 8471
Affinity Capture-MS Homo sapiens
91 PCNP 57092
Negative Genetic Homo sapiens
92 CHMP1A 5119
Affinity Capture-MS Homo sapiens
93 PIP4K2C 79837
Affinity Capture-MS Homo sapiens
94 BRIP1  
Negative Genetic Homo sapiens
95 GMDS 2762
Affinity Capture-MS Homo sapiens
96 USP48  
Negative Genetic Homo sapiens
97 IKBIP 121457
Affinity Capture-MS Homo sapiens
98 UBE2T  
Negative Genetic Homo sapiens
99 EMD 2010
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
100 USPL1  
Negative Genetic Homo sapiens
101 CUL4B 8450
Affinity Capture-MS Homo sapiens
102 TBL2 26608
Affinity Capture-MS Homo sapiens
103 PGAM5 192111
Affinity Capture-MS Homo sapiens
104 SLC25A13 10165
Affinity Capture-MS Homo sapiens
105 CXADR 1525
Proximity Label-MS Homo sapiens
106 C1orf35  
Affinity Capture-MS Homo sapiens
107 LYN 4067
Proximity Label-MS Homo sapiens
108 MCAM 4162
Proximity Label-MS Homo sapiens
109 RCC2 55920
Affinity Capture-MS Homo sapiens
110 RNF146  
Proximity Label-MS Homo sapiens
111 DNAJC5 80331
Proximity Label-MS Homo sapiens
112 C12orf49  
Negative Genetic Homo sapiens
113 RPL18A 6142
Affinity Capture-MS Homo sapiens
114 CDH1 999
Proximity Label-MS Homo sapiens
115 TUBA1C 84790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 CLCC1 23155
Affinity Capture-MS Homo sapiens
117 YAP1 10413
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 PPP1R8 5511
Co-fractionation Homo sapiens
119 TRIM21 6737
Affinity Capture-MS Homo sapiens
120 NEDD4L 23327
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
121 RNF166  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 RPS7 6201
Affinity Capture-MS Homo sapiens
123 PDHX 8050
Affinity Capture-MS Homo sapiens
124 OR4X1  
Affinity Capture-MS Homo sapiens
125 DNAJA1 3301
Affinity Capture-MS Homo sapiens
126 PPP2R3C  
Negative Genetic Homo sapiens
127 FARSA 2193
Affinity Capture-MS Homo sapiens
128 PREB 10113
Affinity Capture-MS Homo sapiens
129 SGSM3  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
130 Tnks2  
Affinity Capture-MS Mus musculus
131 Coro1c 23790
Affinity Capture-MS Mus musculus
132 UBA3 9039
Affinity Capture-MS Homo sapiens
133 MEX3A  
Affinity Capture-RNA Homo sapiens
134 LATS2 26524
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
135 AGAP2  
Reconstituted Complex Homo sapiens
136 BZW1 9689
Negative Genetic Homo sapiens
137 CTDSPL 10217
Proximity Label-MS Homo sapiens
138 Ksr1  
Affinity Capture-Western Mus musculus
139 CYLD  
Affinity Capture-MS Homo sapiens
140 GLTSCR2  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
141 PIPSL 266971
Affinity Capture-MS Homo sapiens
142 SLC25A5 292
Affinity Capture-MS Homo sapiens
143 PMVK 10654
Negative Genetic Homo sapiens
144 SP1  
Affinity Capture-MS Homo sapiens
145 HELQ  
Negative Genetic Homo sapiens
146 TMPO 7112
Affinity Capture-MS Homo sapiens
147 Lin7c 22343
Affinity Capture-MS Mus musculus
148 SRPR 6734
Affinity Capture-MS Homo sapiens
149 HSPA9 3313
Affinity Capture-MS Homo sapiens
150 AK2 204
Negative Genetic Homo sapiens
151 SLC25A12 8604
Affinity Capture-MS Homo sapiens
152 Myh9 17886
Affinity Capture-MS Mus musculus
153 RPL10 6134
Affinity Capture-MS Homo sapiens
154 PXN 5829
Reconstituted Complex Homo sapiens
155 RPS2 6187
Affinity Capture-MS Homo sapiens
156 BYSL 705
Two-hybrid Homo sapiens
157 PANX1 24145
Affinity Capture-MS Homo sapiens
158 TPR 7175
Affinity Capture-MS Homo sapiens
159 SLC25A3 5250
Affinity Capture-MS Homo sapiens
160 VPS18 57617
Negative Genetic Homo sapiens
161 SMAD3 4088
Affinity Capture-MS Homo sapiens
162 RUSC1  
Negative Genetic Homo sapiens
163 SLC25A22  
Affinity Capture-MS Homo sapiens
164 PTPRA 5786
Proximity Label-MS Homo sapiens
165 TXLNB  
Two-hybrid Homo sapiens
166 ASB6 140459
Negative Genetic Homo sapiens
167 RPL14 9045
Affinity Capture-MS Homo sapiens
168 GPD2 2820
Affinity Capture-MS Homo sapiens
169 RPL3 6122
Affinity Capture-MS Homo sapiens
170 GTPBP1 9567
Affinity Capture-MS Homo sapiens
171 PTK2 5747
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
172 DHX30 22907
Affinity Capture-MS Homo sapiens
173 PNRC2  
Affinity Capture-MS Homo sapiens
174 PYCR2 29920
Affinity Capture-MS Homo sapiens
175 RAB35 11021
Proximity Label-MS Homo sapiens
176 RIPK4  
Affinity Capture-MS Homo sapiens
177 RBBP4 5928
Affinity Capture-MS Homo sapiens
178 SPTBN1 6711
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
179 NXF1 10482
Affinity Capture-RNA Homo sapiens
180 TBP  
Affinity Capture-MS Homo sapiens
181 GRSF1 2926
Affinity Capture-MS Homo sapiens
182 SLC25A11 8402
Affinity Capture-MS Homo sapiens
183 FANCA  
Negative Genetic Homo sapiens
184 AGO4  
Negative Genetic Homo sapiens
185 BDKRB1 623
Two-hybrid Homo sapiens
186 CCNL2 81669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
187 WBP2 23558
Affinity Capture-MS Homo sapiens
188 PRPF19 27339
Affinity Capture-MS Homo sapiens
189 PSPC1 55269
Negative Genetic Homo sapiens
190 SERBP1 26135
Affinity Capture-MS Homo sapiens
191 MTTP 4547
Affinity Capture-MS Homo sapiens
192 WWC1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
193 CBR4  
Affinity Capture-MS Homo sapiens
194 TOP1 7150
Affinity Capture-MS Homo sapiens
195 DNPEP 23549
Affinity Capture-MS Homo sapiens
196 TSPYL4 23270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
197 HSPA4 3308
Affinity Capture-MS Homo sapiens
198 DDB1 1642
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 RPL23A 6147
Affinity Capture-MS Homo sapiens
200 RPL18 6141
Affinity Capture-MS Homo sapiens
201 MPP6 51678
Affinity Capture-MS Homo sapiens
202 Yap1  
Affinity Capture-MS Mus musculus
203 RHOB 388
Proximity Label-MS Homo sapiens
204 SMC1A 8243
Affinity Capture-MS Homo sapiens
205 JMJD8  
Negative Genetic Homo sapiens
206 MPRIP 23164
Negative Genetic Homo sapiens
207 AKT1 207
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
208 PYGO2  
Reconstituted Complex Homo sapiens
209 DLAT 1737
Affinity Capture-MS Homo sapiens
210 PPFIA1 8500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
211 ARID2  
Negative Genetic Homo sapiens
212 EIF3M 10480
Affinity Capture-MS Homo sapiens
213 LANCL2 55915
Affinity Capture-MS Homo sapiens
214 FLOT1 10211
Proximity Label-MS Homo sapiens
215 XRCC5 7520
Affinity Capture-MS Homo sapiens
216 HUWE1 10075
Affinity Capture-MS Homo sapiens
217 HECTD1 25831
Negative Genetic Homo sapiens
218 PTTG1  
Negative Genetic Homo sapiens
219 ATP6V1H 51606
Affinity Capture-MS Homo sapiens
220 DBT 1629
Affinity Capture-MS Homo sapiens
221 RPL13 6137
Affinity Capture-MS Homo sapiens
222 DHX15 1665
Affinity Capture-MS Homo sapiens
223 ALS2CL  
Negative Genetic Homo sapiens
224 PEF1 553115
Affinity Capture-MS Homo sapiens
225 EPDR1 54749
Affinity Capture-MS Homo sapiens
226 DDX19A 55308
Negative Genetic Homo sapiens
227 FASN 2194
Positive Genetic Homo sapiens
228 GRN 2896
Affinity Capture-MS Homo sapiens
229 HNRNPH2 3188
Negative Genetic Homo sapiens
230 PARP1 142
Affinity Capture-MS Homo sapiens
231 SLC25A6 293
Affinity Capture-MS Homo sapiens
232 LIG3 3980
Affinity Capture-MS Homo sapiens
233 SUPT20H 55578
Negative Genetic Homo sapiens
234 CPSF6 11052
Affinity Capture-MS Homo sapiens
235 PDCD6IP 10015
Affinity Capture-MS Homo sapiens
236 PDCL 5082
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
237 DNAJA2 10294
Affinity Capture-MS Homo sapiens
238 SF3B4 10262
Affinity Capture-MS Homo sapiens
239 HSD17B4 3295
Affinity Capture-MS Homo sapiens
240 SEC23B 10483
Affinity Capture-MS Homo sapiens
241 EZR 7430
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
242 RPA1 6117
Affinity Capture-MS Homo sapiens
243 C1orf27 54953
Negative Genetic Homo sapiens
244 PDCD6 10016
Affinity Capture-MS Homo sapiens
245 RPS4X 6191
Affinity Capture-MS Homo sapiens
246 SOS1 6654
Affinity Capture-Western Homo sapiens
247 ERLIN2 11160
Affinity Capture-MS Homo sapiens
248 PRKAG2 51422
Affinity Capture-MS Homo sapiens
249 HDAC1 3065
Affinity Capture-MS Homo sapiens
250 VTA1 51534
Affinity Capture-MS Homo sapiens
251 ZBTB10 65986
Affinity Capture-MS Homo sapiens
252 G3BP2 9908
Affinity Capture-MS Homo sapiens
253 S100A9 6280
Affinity Capture-MS Homo sapiens
254 C11orf52 91894
Proximity Label-MS Homo sapiens
255 TUBB4A 10382
Affinity Capture-MS Homo sapiens
256 CDK1 983
Affinity Capture-MS Homo sapiens
257 LATS1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
258 S100A8 6279
Affinity Capture-MS Homo sapiens
259 ATAD3A 55210
Affinity Capture-MS Homo sapiens
260 Schip1  
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
261 LIN7C 55327
Affinity Capture-MS Homo sapiens
262 KDM1A 23028
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
263 MOV10 4343
Affinity Capture-RNA Homo sapiens
264 EIF3J 8669
Affinity Capture-MS Homo sapiens
265 TGM3 7053
Affinity Capture-MS Homo sapiens
266 CALML5 51806
Affinity Capture-MS Homo sapiens
267 IST1 9798
Affinity Capture-MS Homo sapiens
268 TYMS 7298
Negative Genetic Homo sapiens
269 SLC33A1 9197
Affinity Capture-MS Homo sapiens
270 PRKCA 5578
Biochemical Activity Homo sapiens
271 SLC9A3R1 9368
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
272 CIT 11113
Affinity Capture-MS Homo sapiens
273 RPL8 6132
Affinity Capture-MS Homo sapiens
274 Flot1 14251
Affinity Capture-MS Mus musculus
275 EPHA2 1969
Proximity Label-MS Homo sapiens
276 XRCC6 2547
Affinity Capture-MS Homo sapiens
277 CUL7 9820
Affinity Capture-MS Homo sapiens
278 KRAS 3845
Proximity Label-MS Homo sapiens
279 RARS 5917
Affinity Capture-MS Homo sapiens
280 CD44 960
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
281 CHMP4B 128866
Affinity Capture-MS Homo sapiens
282 RPL36AL 6166
Affinity Capture-MS Homo sapiens
283 METTL17  
Affinity Capture-MS Homo sapiens
284 PRDX1 5052
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
285 SSRP1 6749
Affinity Capture-MS Homo sapiens
286 RPA2 6118
Affinity Capture-MS Homo sapiens
287 RPS3 6188
Affinity Capture-MS Homo sapiens
288 CAV1 857
Proximity Label-MS Homo sapiens
289 KCNA3  
Negative Genetic Homo sapiens
290 LURAP1  
Affinity Capture-MS Homo sapiens
291 LUC7L3 51747
Affinity Capture-MS Homo sapiens
292 CUL4A 8451
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
293 MED28  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here