Gene description for APOBEC3C
Gene name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
Gene symbol APOBEC3C
Other names/aliases A3C
APOBEC1L
ARDC2
ARDC4
ARP5
PBI
bK150C2.3
Species Homo sapiens
 Database cross references - APOBEC3C
ExoCarta ExoCarta_27350
Vesiclepedia VP_27350
Entrez Gene 27350
HGNC 17353
MIM 607750
UniProt Q9NRW3  
 APOBEC3C identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for APOBEC3C
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    cytidine deaminase activity GO:0004126 IBA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    cytidine deamination GO:0009972 IDA
    transposable element silencing GO:0010526 IDA
    cytidine to uridine editing GO:0016554 IBA
    positive regulation of gene expression via chromosomal CpG island demethylation GO:0044029 IDA
    clearance of foreign intracellular DNA GO:0044355 IDA
    negative regulation of viral genome replication GO:0045071 IDA
    innate immune response GO:0045087 IEA
    negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045869 IBA
    defense response to virus GO:0051607 IBA
    DNA cytosine deamination GO:0070383 IBA
Subcellular Localization
    P-body GO:0000932 IBA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified APOBEC3C in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for APOBEC3C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPF1  
Affinity Capture-MS Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 XPC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RPL26L1 51121
Affinity Capture-MS Homo sapiens
5 TRMT1L 81627
Affinity Capture-MS Homo sapiens
6 CD3EAP  
Affinity Capture-MS Homo sapiens
7 RBMY1F  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 ZBTB11  
Affinity Capture-MS Homo sapiens
9 HMCES  
Affinity Capture-MS Homo sapiens
10 RPS3A 6189
Affinity Capture-MS Homo sapiens
11 CTPS2 56474
Affinity Capture-MS Homo sapiens
12 SRPK2 6733
Biochemical Activity Homo sapiens
13 ZNF668  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 GTPBP10  
Affinity Capture-MS Homo sapiens
15 SDAD1  
Affinity Capture-MS Homo sapiens
16 NMNAT1  
Affinity Capture-MS Homo sapiens
17 RPL10 6134
Affinity Capture-MS Homo sapiens
18 NOA1  
Affinity Capture-MS Homo sapiens
19 ZFR 51663
Affinity Capture-MS Homo sapiens
20 RPL14 9045
Affinity Capture-MS Homo sapiens
21 URB2  
Affinity Capture-MS Homo sapiens
22 DHX57 90957
Affinity Capture-MS Homo sapiens
23 UNKL  
Two-hybrid Homo sapiens
24 PCBP3 54039
Two-hybrid Homo sapiens
25 WDR36 134430
Affinity Capture-MS Homo sapiens
26 NOL8  
Affinity Capture-MS Homo sapiens
27 KBTBD6  
Affinity Capture-MS Homo sapiens
28 CENPU  
Affinity Capture-MS Homo sapiens
29 ZNF189  
Affinity Capture-MS Homo sapiens
30 RSBN1L  
Affinity Capture-MS Homo sapiens
31 ZNF408  
Two-hybrid Homo sapiens
32 KIF23 9493
Affinity Capture-MS Homo sapiens
33 MCM2 4171
Affinity Capture-MS Homo sapiens
34 DUSP11  
Affinity Capture-MS Homo sapiens
35 ANOS1 3730
Affinity Capture-MS Homo sapiens
36 RRS1 23212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 POLR1E  
Affinity Capture-MS Homo sapiens
38 Hnrnpk 15387
Two-hybrid Mus musculus
39 RPF2 84154
Affinity Capture-MS Homo sapiens
40 PRKRA 8575
Affinity Capture-MS Homo sapiens
41 DDX51  
Affinity Capture-MS Homo sapiens
42 FYTTD1  
Affinity Capture-MS Homo sapiens
43 NOC3L 64318
Affinity Capture-MS Homo sapiens
44 DDX18 8886
Affinity Capture-MS Homo sapiens
45 BLM 641
Affinity Capture-MS Homo sapiens
46 Eif3i 54709
Affinity Capture-MS Mus musculus
47 MYCN  
Affinity Capture-MS Homo sapiens
48 CHD3 1107
Affinity Capture-MS Homo sapiens
49 RBM19 9904
Affinity Capture-MS Homo sapiens
50 LIN28A  
Affinity Capture-MS Homo sapiens
51 RBMX 27316
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
52 BRIX1 55299
Affinity Capture-MS Homo sapiens
53 DDX31  
Affinity Capture-MS Homo sapiens
54 CDKN2AIP  
Affinity Capture-MS Homo sapiens
55 ZKSCAN8  
Affinity Capture-MS Homo sapiens
56 WDR45B 56270
Affinity Capture-MS Homo sapiens
57 DDX21 9188
Affinity Capture-MS Homo sapiens
58 RBM28 55131
Affinity Capture-MS Homo sapiens
59 WDR89  
Affinity Capture-MS Homo sapiens
60 POLRMT 5442
Affinity Capture-MS Homo sapiens
61 RBM7  
Two-hybrid Homo sapiens
62 STAU1 6780
Affinity Capture-MS Homo sapiens
63 CLTCL1 8218
Affinity Capture-MS Homo sapiens
64 ZBTB48  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 SRBD1  
Affinity Capture-MS Homo sapiens
66 MYO10 4651
Two-hybrid Homo sapiens
67 RAD18  
Affinity Capture-MS Homo sapiens
68 DDX54 79039
Affinity Capture-MS Homo sapiens
69 ZNF581  
Two-hybrid Homo sapiens
70 TAF1B  
Affinity Capture-MS Homo sapiens
71 NECAP1 25977
Affinity Capture-MS Homo sapiens
72 RPS26P11  
Affinity Capture-MS Homo sapiens
73 PRPF31 26121
Two-hybrid Homo sapiens
74 DDX27 55661
Affinity Capture-MS Homo sapiens
75 SRPK1 6732
Affinity Capture-MS Homo sapiens
76 PCBP2 5094
Two-hybrid Homo sapiens
77 CNBP 7555
Affinity Capture-MS Homo sapiens
78 FGFBP1 9982
Affinity Capture-MS Homo sapiens
79 RRP8  
Affinity Capture-MS Homo sapiens
80 NUMA1 4926
Affinity Capture-MS Homo sapiens
81 ZNF316  
Affinity Capture-MS Homo sapiens
82 BMS1  
Affinity Capture-MS Homo sapiens
83 ABT1 29777
Affinity Capture-MS Homo sapiens
84 RPL7A 6130
Affinity Capture-MS Homo sapiens
85 RBMY1A1  
Two-hybrid Homo sapiens
86 LMNB1 4001
Affinity Capture-MS Homo sapiens
87 YTHDC2 64848
Affinity Capture-MS Homo sapiens
88 NAT10 55226
Affinity Capture-MS Homo sapiens
89 MRPL9 65005
Affinity Capture-MS Homo sapiens
90 SF1 7536
Two-hybrid Homo sapiens
91 ZNF250  
Two-hybrid Homo sapiens
92 DHX30 22907
Affinity Capture-MS Homo sapiens
93 DHX37  
Affinity Capture-MS Homo sapiens
94 PDCD11 22984
Affinity Capture-MS Homo sapiens
95 TRAF3 7187
Two-hybrid Homo sapiens
96 Pcbp1 23983
Two-hybrid Mus musculus
97 NIP7 51388
Affinity Capture-MS Homo sapiens
98 FN1 2335
Affinity Capture-MS Homo sapiens
99 PUS7 54517
Affinity Capture-MS Homo sapiens
100 NXF1 10482
Two-hybrid Homo sapiens
101 PRR3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
102 RPA3 6119
Proximity Label-MS Homo sapiens
103 RPS13 6207
Affinity Capture-MS Homo sapiens
104 ZCCHC6 79670
Affinity Capture-MS Homo sapiens
105 HP1BP3 50809
Affinity Capture-MS Homo sapiens
106 CUL7 9820
Affinity Capture-MS Homo sapiens
107 DDRGK1 65992
Affinity Capture-MS Homo sapiens
108 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
109 SHBG 6462
Two-hybrid Homo sapiens
110 ZFP62  
Affinity Capture-MS Homo sapiens
111 KBTBD7  
Affinity Capture-MS Homo sapiens
112 EGLN1 54583
Affinity Capture-MS Homo sapiens
113 ZC3H3  
Affinity Capture-MS Homo sapiens
114 FTSJ3 117246
Affinity Capture-MS Homo sapiens
115 SUPT16H 11198
Affinity Capture-MS Homo sapiens
116 TAF1A  
Affinity Capture-MS Homo sapiens
117 DDX55  
Affinity Capture-MS Homo sapiens
118 C10orf2 56652
Affinity Capture-MS Homo sapiens
119 NGDN  
Affinity Capture-MS Homo sapiens
120 RBMY1J  
Two-hybrid Homo sapiens
121 ZNF574  
Affinity Capture-MS Homo sapiens
122 CLPP 8192
Proximity Label-MS Homo sapiens
123 SURF6  
Affinity Capture-MS Homo sapiens
124 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
125 ZC3H10  
Affinity Capture-MS Homo sapiens
126 ZNF689  
Affinity Capture-MS Homo sapiens
127 PARP1 142
Affinity Capture-MS Homo sapiens
128 HHEX  
Two-hybrid Homo sapiens
129 ILF3 3609
Affinity Capture-MS Homo sapiens
130 CHTOP  
Two-hybrid Homo sapiens
131 THUMPD3 25917
Affinity Capture-MS Homo sapiens
132 NLE1 54475
Affinity Capture-MS Homo sapiens
133 APOBEC3D  
Affinity Capture-MS Homo sapiens
134 ISCA2 122961
Affinity Capture-MS Homo sapiens
135 ZNF445  
Affinity Capture-MS Homo sapiens
136 SNRPA 6626
Two-hybrid Homo sapiens
137 HMGN5 79366
Affinity Capture-MS Homo sapiens
138 LENG8  
Affinity Capture-MS Homo sapiens
139 ZNF48  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
140 URB1 9875
Affinity Capture-MS Homo sapiens
141 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
142 RBAK  
Affinity Capture-MS Homo sapiens
143 TAF1D  
Affinity Capture-MS Homo sapiens
144 PATZ1  
Affinity Capture-MS Homo sapiens
145 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
146 HNRNPK 3190
Two-hybrid Homo sapiens
147 RBM23  
Affinity Capture-MS Homo sapiens
148 NEIL1  
Affinity Capture-MS Homo sapiens
149 NOC2L 26155
Affinity Capture-MS Homo sapiens
150 TEFM  
Affinity Capture-MS Homo sapiens
151 ZNF768 79724
Affinity Capture-MS Homo sapiens
152 TRIB3  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
153 TAF1C  
Affinity Capture-MS Homo sapiens
154 RPL28 6158
Affinity Capture-MS Homo sapiens
155 ZNF629 23361
Affinity Capture-MS Homo sapiens
156 SNW1 22938
Two-hybrid Homo sapiens
157 SSRP1 6749
Affinity Capture-MS Homo sapiens
158 PHF8  
Affinity Capture-MS Homo sapiens
159 STRBP 55342
Affinity Capture-MS Homo sapiens
160 NVL  
Affinity Capture-MS Homo sapiens
161 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
162 PRKRIR  
Affinity Capture-MS Homo sapiens
163 ZNF770 54989
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which APOBEC3C is involved
PathwayEvidenceSource
Formation of the Editosome TAS Reactome
Metabolism of RNA TAS Reactome
mRNA Editing TAS Reactome
mRNA Editing: C to U Conversion TAS Reactome





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