Gene description for NUP98
Gene name nucleoporin 98kDa
Gene symbol NUP98
Other names/aliases ADIR2
Species Homo sapiens
 Database cross references - NUP98
ExoCarta ExoCarta_4928
Entrez Gene 4928
HGNC 8068
MIM 601021
UniProt P52948  
 NUP98 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NUP98
Molecular Function
    protein binding GO:0005515 IPI
    peptide binding GO:0042277 IEA
    transporter activity GO:0005215 TAS
    structural constituent of nuclear pore GO:0017056 NAS
Biological Process
    nucleocytoplasmic transport GO:0006913 TAS
    cellular protein metabolic process GO:0044267 TAS
    nuclear pore organization GO:0006999 NAS
    mitotic nuclear envelope disassembly GO:0007077 TAS
    small GTPase mediated signal transduction GO:0007264 TAS
    glucose transport GO:0015758 TAS
    protein sumoylation GO:0016925 TAS
    gene expression GO:0010467 TAS
    DNA replication GO:0006260 IMP
    transmembrane transport GO:0055085 TAS
    nuclear pore complex assembly GO:0051292 IMP
    mitotic cell cycle GO:0000278 TAS
    regulation of glucose transport GO:0010827 TAS
    post-translational protein modification GO:0043687 TAS
    viral life cycle GO:0019058 TAS
    viral process GO:0016032 TAS
    cellular response to heat GO:0034605 TAS
    protein import into nucleus, docking GO:0000059 NAS
    cytokine-mediated signaling pathway GO:0019221 TAS
    regulation of cellular response to heat GO:1900034 TAS
    mRNA transport GO:0051028 IEA
    hexose transport GO:0008645 TAS
    small molecule metabolic process GO:0044281 TAS
    viral transcription GO:0019083 TAS
    carbohydrate metabolic process GO:0005975 TAS
Subcellular Localization
    nuclear membrane GO:0031965 IDA
    nuclear inclusion body GO:0042405 IDA
    cytosol GO:0005829 TAS
    nuclear envelope GO:0005635 TAS
    nuclear periphery GO:0034399 IDA
    nuclear pore outer ring GO:0031080 NAS
    nuclear pore GO:0005643 NAS
    kinetochore GO:0000776 IDA
    nuclear pore nuclear basket GO:0044615 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified NUP98 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NUP98
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rae1  
Reconstituted Complex Mus musculus
2 RCC1 1104
Invitro Homo sapiens
3 KPNB1 3837
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
4 NUP88 4927
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 MOB1A 55233
Affinity Capture-MS Homo sapiens
6 NUP133  
Affinity Capture-MS Homo sapiens
7 DKFZP434P0316  
Affinity Capture-MS Homo sapiens
8 EP300 2033
Affinity Capture-Western Homo sapiens
9 IPO5 3843
Invitro Homo sapiens
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
11 RAE1 8480
Invivo Homo sapiens
Invitro Homo sapiens
12 NFX1  
Reconstituted Complex Homo sapiens
13 TPR 7175
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
14 TNPO1 3842
Invitro Homo sapiens
Invitro Homo sapiens
15 PARP11  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NUP98 is involved
No pathways found

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