Gene description for SMARCA5
Gene name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Gene symbol SMARCA5
Other names/aliases ISWI
SNF2H
WCRF135
hISWI
hSNF2H
Species Homo sapiens
 Database cross references - SMARCA5
ExoCarta ExoCarta_8467
Vesiclepedia VP_8467
Entrez Gene 8467
HGNC 11101
MIM 603375
UniProt O60264  
 SMARCA5 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Endothelial cells 26027894    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for SMARCA5
Molecular Function
    DNA binding GO:0003677 IBA
    DNA binding GO:0003677 IDA
    chromatin binding GO:0003682 IBA
    helicase activity GO:0004386 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    ATP hydrolysis activity GO:0016887 IDA
    nucleosome binding GO:0031491 IEA
    histone binding GO:0042393 IDA
    ATP-dependent chromatin remodeler activity GO:0140658 IDA
    ATP-dependent chromatin remodeler activity GO:0140658 IMP
    nucleosome array spacer activity GO:0140750 IBA
    histone octamer slider activity GO:0140751 IDA
Biological Process
    rDNA heterochromatin formation GO:0000183 ISO
    regulation of DNA replication GO:0006275 IMP
    DNA repair GO:0006281 IDA
    chromatin organization GO:0006325 IDA
    nucleosome assembly GO:0006334 EXP
    nucleosome assembly GO:0006334 IDA
    chromatin remodeling GO:0006338 IDA
    chromatin remodeling GO:0006338 IMP
    chromatin remodeling GO:0006338 ISO
    chromatin remodeling GO:0006338 NAS
    DNA methylation-dependent constitutive heterochromatin formation GO:0006346 ISO
    DNA-templated transcription initiation GO:0006352 IDA
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of transcription by RNA polymerase II GO:0006357 TAS
    DNA damage response GO:0006974 NAS
    negative regulation of transcription by RNA polymerase I GO:0016479 ISO
    heterochromatin formation GO:0031507 IBA
    heterochromatin formation GO:0031507 ISO
    positive regulation of DNA replication GO:0045740 IMP
    positive regulation of transcription by RNA polymerase I GO:0045943 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 NAS
    positive regulation of transcription by RNA polymerase III GO:0045945 IDA
    antiviral innate immune response GO:0140374 IDA
    negative regulation of mitotic chromosome condensation GO:1905213 IDA
    negative regulation of mitotic chromosome condensation GO:1905213 IMP
    cellular response to leukemia inhibitory factor GO:1990830 IEA
Subcellular Localization
    chromatin GO:0000785 IBA
    condensed chromosome GO:0000793 IDA
    fibrillar center GO:0001650 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    chromatin silencing complex GO:0005677 IEA
    pericentric heterochromatin GO:0005721 EXP
    pericentric heterochromatin GO:0005721 ISO
    nucleolus GO:0005730 NAS
    CHRAC GO:0008623 NAS
    NURF complex GO:0016589 IDA
    ACF complex GO:0016590 IPI
    RSF complex GO:0031213 IPI
    site of double-strand break GO:0035861 IDA
    nuclear replication fork GO:0043596 IDA
    WICH complex GO:0090535 IDA
    NoRC complex GO:0090536 ISO
    B-WICH complex GO:0110016 IDA
 Experiment description of studies that identified SMARCA5 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
12
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
17
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
18
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
27
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
28
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
30
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
31
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
32
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
35
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SMARCA5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FNBP1 23048
Co-fractionation Homo sapiens
2 RING1 6015
Co-fractionation Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
4 MCM3 4172
Co-localization Homo sapiens
5 HSPA5 3309
Co-fractionation Homo sapiens
6 SMC3 9126
Co-purification Homo sapiens
Co-fractionation Homo sapiens
7 ING4  
Affinity Capture-MS Homo sapiens
8 Cbx2  
Affinity Capture-MS Mus musculus
9 GATAD2B 57459
Affinity Capture-MS Homo sapiens
10 HDAC2 3066
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
11 VARS 7407
Co-fractionation Homo sapiens
12 MAGEA3  
Affinity Capture-MS Homo sapiens
13 RPS3A 6189
Co-fractionation Homo sapiens
14 KPNA1 3836
Affinity Capture-MS Homo sapiens
15 RPL13 6137
Affinity Capture-MS Homo sapiens
16 COX15 1355
Affinity Capture-MS Homo sapiens
17 RPL30 6156
Affinity Capture-MS Homo sapiens
18 TNPO1 3842
Co-fractionation Homo sapiens
19 RPA2 6118
Affinity Capture-MS Homo sapiens
20 NFATC1 4772
Affinity Capture-MS Homo sapiens
21 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
22 ACTC1 70
Proximity Label-MS Homo sapiens
23 BRCA1 672
Affinity Capture-MS Homo sapiens
24 PRPF4 9128
Co-fractionation Homo sapiens
25 RPS19 6223
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
26 RPL10 6134
Affinity Capture-MS Homo sapiens
27 KIF20A 10112
Affinity Capture-MS Homo sapiens
28 BRD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 MAP4K4 9448
Affinity Capture-MS Homo sapiens
30 SAP30 8819
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
31 HNRNPR 10236
Co-fractionation Homo sapiens
32 STAG1  
Co-fractionation Homo sapiens
33 PRPF40A 55660
Co-fractionation Homo sapiens
34 SEPT2 4735
Co-fractionation Homo sapiens
35 SOX2  
Affinity Capture-MS Homo sapiens
36 CENPA  
Co-purification Homo sapiens
Proximity Label-MS Homo sapiens
37 GSK3A 2931
Two-hybrid Homo sapiens
38 USP36  
Affinity Capture-MS Homo sapiens
39 KIAA1429 25962
Co-fractionation Homo sapiens
40 WTAP 9589
Co-fractionation Homo sapiens
41 CPSF2 53981
Co-fractionation Homo sapiens
42 CHD4 1108
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
43 RUVBL1 8607
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
44 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
45 UFM1 51569
Cross-Linking-MS (XL-MS) Homo sapiens
46 MTF2  
Affinity Capture-MS Homo sapiens
47 TFAM 7019
Affinity Capture-MS Homo sapiens
48 SSRP1 6749
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
49 KIF23 9493
Co-fractionation Homo sapiens
50 CEBPB  
Affinity Capture-Western Homo sapiens
51 DDB1 1642
Co-fractionation Homo sapiens
52 MYO1E 4643
Affinity Capture-MS Homo sapiens
53 SF3B1 23451
Co-fractionation Homo sapiens
54 SMARCA1 6594
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
55 CDK2AP1  
Affinity Capture-MS Homo sapiens
56 RCN1 5954
Co-fractionation Homo sapiens
57 COPS5 10987
Co-fractionation Homo sapiens
58 PRC1 9055
Affinity Capture-MS Homo sapiens
59 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 ZNF512B  
Affinity Capture-MS Homo sapiens
61 RBBP4 5928
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
62 NUP93 9688
Co-fractionation Homo sapiens
63 OBSL1 23363
Affinity Capture-MS Homo sapiens
64 SMC2 10592
Co-fractionation Homo sapiens
65 SMARCA4 6597
Co-fractionation Homo sapiens
66 HMGA1 3159
Affinity Capture-MS Homo sapiens
67 ABCE1 6059
Affinity Capture-MS Homo sapiens
68 RTN1 6252
Affinity Capture-MS Homo sapiens
69 BEND3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 NELFE 7936
Affinity Capture-MS Homo sapiens
71 EED  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CDT1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
73 DDX18 8886
Affinity Capture-MS Homo sapiens
74 ATG16L1 55054
Affinity Capture-MS Homo sapiens
75 BPTF 2186
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
76 KLHL20  
Affinity Capture-MS Homo sapiens
77 PHF1  
Affinity Capture-MS Homo sapiens
78 POLR3A 11128
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
79 MYCN  
Affinity Capture-MS Homo sapiens
80 GPS1 2873
Co-fractionation Homo sapiens
81 CHD3 1107
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
82 CSNK2B 1460
Affinity Capture-MS Homo sapiens
83 SMARCA2 6595
Co-fractionation Homo sapiens
84 NCSTN 23385
Co-fractionation Homo sapiens
85 MTA2 9219
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
86 RBM14 10432
Co-fractionation Homo sapiens
87 RBPJ 3516
Affinity Capture-MS Homo sapiens
88 KIF14 9928
Affinity Capture-MS Homo sapiens
89 Cebpb  
Affinity Capture-Western Rattus norvegicus
90 HSPA8 3312
Co-fractionation Homo sapiens
91 SMC4 10051
Co-fractionation Homo sapiens
92 TMA7 51372
Cross-Linking-MS (XL-MS) Homo sapiens
93 POLR2E 5434
Co-fractionation Homo sapiens
94 PDZD8 118987
Affinity Capture-MS Homo sapiens
95 POLR1A 25885
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
96 CHMP4C 92421
Affinity Capture-MS Homo sapiens
97 H2AFZ 3015
Affinity Capture-MS Homo sapiens
98 PPP1CA 5499
Co-fractionation Homo sapiens
99 RBBP5 5929
Co-fractionation Homo sapiens
100 HIST2H3C 126961
Co-fractionation Homo sapiens
101 RBBP7 5931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
102 SYMPK 8189
Co-fractionation Homo sapiens
103 FOXC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 HIST2H2AB 317772
Affinity Capture-Western Homo sapiens
105 CUL4A 8451
Co-fractionation Homo sapiens
106 HIST1H4A 8359
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
107 DDX21 9188
Co-fractionation Homo sapiens
108 TUBA1C 84790
Co-fractionation Homo sapiens
109 Set 56086
Affinity Capture-MS Mus musculus
110 PARK2  
Affinity Capture-MS Homo sapiens
111 WHSC1 7468
Proximity Label-MS Homo sapiens
112 RABL6 55684
Co-fractionation Homo sapiens
113 C17orf49 124944
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 REXO4  
Affinity Capture-MS Homo sapiens
115 DEK 7913
Co-fractionation Homo sapiens
116 SSX2  
Affinity Capture-MS Homo sapiens
117 SRRT 51593
Co-fractionation Homo sapiens
118 CBX3 11335
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
119 AHCYL1 10768
Co-fractionation Homo sapiens
120 RNF4 6047
Affinity Capture-MS Homo sapiens
121 KDM1A 23028
Co-fractionation Homo sapiens
122 DPY30 84661
Affinity Capture-MS Homo sapiens
123 FGFBP1 9982
Affinity Capture-MS Homo sapiens
124 YAP1 10413
Affinity Capture-MS Homo sapiens
125 VCP 7415
Affinity Capture-MS Homo sapiens
126 RNF168  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
127 NTRK1 4914
Affinity Capture-MS Homo sapiens
128 FOXK2  
Affinity Capture-MS Homo sapiens
129 CECR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
130 IFI16 3428
Affinity Capture-MS Homo sapiens
131 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
132 ARNT 405
Affinity Capture-MS Homo sapiens
133 FOXC2  
Affinity Capture-MS Homo sapiens
134 TEAD2  
Affinity Capture-MS Homo sapiens
135 BRMS1L  
Affinity Capture-MS Homo sapiens
136 MYBL2 4605
Affinity Capture-MS Homo sapiens
137 HUWE1 10075
Co-fractionation Homo sapiens
138 MBD2 8932
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
139 UBTF 7343
Affinity Capture-Western Homo sapiens
140 SMC1A 8243
Co-purification Homo sapiens
Co-fractionation Homo sapiens
141 COPS3 8533
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
142 PRKDC 5591
Co-fractionation Homo sapiens
143 STAG2 10735
Co-fractionation Homo sapiens
144 HECTD1 25831
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
145 SUDS3  
Affinity Capture-MS Homo sapiens
146 MBD3 53615
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
147 MAGEB2 4113
Affinity Capture-MS Homo sapiens
148 FOXJ3  
Affinity Capture-MS Homo sapiens
149 NECAP1 25977
Affinity Capture-MS Homo sapiens
150 MYBBP1A 10514
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
151 RAD21 5885
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
152 DAXX  
Affinity Capture-MS Homo sapiens
153 PIPSL 266971
Affinity Capture-MS Homo sapiens
154 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
155 IPO9 55705
Co-fractionation Homo sapiens
156 SMARCC2 6601
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
157 KDF1  
Affinity Capture-MS Homo sapiens
158 SCARNA22  
Affinity Capture-RNA Homo sapiens
159 BCL11A 53335
Affinity Capture-MS Homo sapiens
160 NUMA1 4926
Affinity Capture-MS Homo sapiens
161 PPAN 56342
Affinity Capture-MS Homo sapiens
162 SFPQ 6421
Co-fractionation Homo sapiens
163 CHRAC1  
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
164 ZBTB2 57621
Affinity Capture-MS Homo sapiens
165 TUBB 203068
Co-fractionation Homo sapiens
166 GOLGA3 2802
Co-fractionation Homo sapiens
167 AIM2  
Affinity Capture-MS Homo sapiens
168 HIST1H3A 8350
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
169 FANCD2  
Affinity Capture-MS Homo sapiens
170 SMARCAD1  
Affinity Capture-MS Homo sapiens
171 MSH2 4436
Co-fractionation Homo sapiens
172 BAZ1B 9031
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
173 C9orf78 51759
Affinity Capture-MS Homo sapiens
174 USP15 9958
Co-fractionation Homo sapiens
175 TPR 7175
Co-fractionation Homo sapiens
176 ECT2 1894
Affinity Capture-MS Homo sapiens
177 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
178 SRSF1 6426
Affinity Capture-RNA Homo sapiens
179 TUBB4B 10383
Co-fractionation Homo sapiens
180 U2AF2 11338
Co-fractionation Homo sapiens
181 RLIM 51132
Affinity Capture-MS Homo sapiens
182 FOXG1  
Affinity Capture-MS Homo sapiens
183 RAD18  
Affinity Capture-MS Homo sapiens
184 MECP2 4204
Affinity Capture-MS Homo sapiens
185 WDR11 55717
Co-fractionation Homo sapiens
186 YY1 7528
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
187 H1F0 3005
Affinity Capture-MS Homo sapiens
188 FOXL1  
Affinity Capture-MS Homo sapiens
189 Fbxo21  
Affinity Capture-MS Mus musculus
190 FTH1 2495
Co-fractionation Homo sapiens
191 SUZ12  
Affinity Capture-MS Homo sapiens
192 SS18  
Affinity Capture-MS Homo sapiens
193 EFTUD2 9343
Co-fractionation Homo sapiens
194 CDK2 1017
Affinity Capture-MS Homo sapiens
195 CREB1  
Affinity Capture-Western Homo sapiens
196 DNMT3B  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
197 LIN9  
Affinity Capture-MS Homo sapiens
198 MYC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
200 NLRP3  
Affinity Capture-MS Homo sapiens
201 DLST 1743
Affinity Capture-MS Homo sapiens
202 WDR5 11091
Co-fractionation Homo sapiens
203 INO80  
Co-fractionation Homo sapiens
204 TOP1 7150
Affinity Capture-MS Homo sapiens
205 BRD4 23476
Affinity Capture-MS Homo sapiens
206 Bmi1  
Affinity Capture-MS Mus musculus
207 BAZ1A 11177
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
208 SNW1 22938
Affinity Capture-MS Homo sapiens
209 FLII 2314
Co-fractionation Homo sapiens
210 PARP1 142
Affinity Capture-MS Homo sapiens
211 RNF2  
Affinity Capture-MS Homo sapiens
212 BMI1  
Affinity Capture-MS Homo sapiens
213 FOXQ1  
Affinity Capture-MS Homo sapiens
214 SEPT7 989
Co-fractionation Homo sapiens
215 Eif3e 16341
Affinity Capture-MS Mus musculus
216 TSR1 55720
Co-fractionation Homo sapiens
217 NFATC2  
Affinity Capture-MS Homo sapiens
218 BRD3 8019
Affinity Capture-MS Homo sapiens
219 SUPT16H 11198
Co-fractionation Homo sapiens
220 PYHIN1  
Affinity Capture-MS Homo sapiens
221 NCAPG 64151
Co-fractionation Homo sapiens
222 XRCC5 7520
Affinity Capture-Western Homo sapiens
223 CCDC8  
Affinity Capture-MS Homo sapiens
224 PHGDH 26227
Co-fractionation Homo sapiens
225 SATB1 6304
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
226 RALY 22913
Co-fractionation Homo sapiens
227 GATAD2A 54815
Affinity Capture-MS Homo sapiens
228 Cbx1  
Affinity Capture-MS Mus musculus
229 DEPDC1B 55789
Affinity Capture-MS Homo sapiens
230 TAF6 6878
Co-fractionation Homo sapiens
231 MYO1C 4641
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
232 NCK1 4690
Affinity Capture-MS Homo sapiens
233 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
234 MKRN1 23608
Affinity Capture-MS Homo sapiens
235 SHCBP1 79801
Co-fractionation Homo sapiens
236 SIRT6  
Affinity Capture-MS Homo sapiens
237 TP53 7157
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
238 HMGN4  
Affinity Capture-MS Homo sapiens
239 HDGF 3068
Affinity Capture-MS Homo sapiens
240 MAX  
Affinity Capture-MS Homo sapiens
241 SIN3A  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
242 ZFP91 80829
Co-fractionation Homo sapiens
243 RUVBL2 10856
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
244 EML4 27436
Co-fractionation Homo sapiens
245 FOXJ2  
Affinity Capture-MS Homo sapiens
246 FOXB1  
Affinity Capture-MS Homo sapiens
247 SMARCC1 6599
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
248 RPA1 6117
Affinity Capture-MS Homo sapiens
249 SAP18 10284
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
250 POLE3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
251 CUL5 8065
Affinity Capture-MS Homo sapiens
252 PDHA1 5160
Affinity Capture-MS Homo sapiens
253 HMGN5 79366
Affinity Capture-MS Homo sapiens
254 HNRNPM 4670
Co-fractionation Homo sapiens
255 TUBB3 10381
Co-fractionation Homo sapiens
256 UTP23  
Affinity Capture-MS Homo sapiens
257 MTA1 9112
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
258 HDAC1 3065
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
259 BAZ2A  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
260 EIF4A3 9775
Co-fractionation Homo sapiens
261 EPB41L2 2037
Co-fractionation Homo sapiens
262 S100A9 6280
Co-fractionation Homo sapiens
263 DDX58 23586
Affinity Capture-RNA Homo sapiens
264 MTA3 57504
Affinity Capture-MS Homo sapiens
265 COBLL1 22837
Co-fractionation Homo sapiens
266 ESR1  
Affinity Capture-MS Homo sapiens
267 TLR9  
Affinity Capture-MS Homo sapiens
268 HMGXB4 10042
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
269 DNAJA2 10294
Co-fractionation Homo sapiens
270 KRR1 11103
Affinity Capture-MS Homo sapiens
271 LIN37  
Affinity Capture-MS Homo sapiens
272 IK 3550
Co-fractionation Homo sapiens
273 RPL38 6169
Cross-Linking-MS (XL-MS) Homo sapiens
274 PPP1R12A 4659
Co-fractionation Homo sapiens
275 NCL 4691
Affinity Capture-MS Homo sapiens
276 EZH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
277 POLR1C 9533
Co-fractionation Homo sapiens
278 SNRNP70 6625
Co-fractionation Homo sapiens
279 HNRNPC 3183
Co-fractionation Homo sapiens
280 FOXS1  
Affinity Capture-MS Homo sapiens
281 SMARCB1 6598
Co-fractionation Homo sapiens
282 Rrbp1  
Affinity Capture-MS Mus musculus
283 DHX38 9785
Co-fractionation Homo sapiens
284 POLR3B 55703
Co-fractionation Homo sapiens
285 RCOR1  
Co-fractionation Homo sapiens
286 FOXM1  
Affinity Capture-MS Homo sapiens
287 MAF  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
288 LRRFIP1 9208
Co-fractionation Homo sapiens
289 FOXR1  
Affinity Capture-MS Homo sapiens
290 CUL7 9820
Affinity Capture-MS Homo sapiens
291 KRAS 3845
Negative Genetic Homo sapiens
292 HNRNPU 3192
Affinity Capture-MS Homo sapiens
293 ZC3H13 23091
Co-fractionation Homo sapiens
294 USF1  
Affinity Capture-MS Homo sapiens
295 RSF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
296 PWWP2A  
Affinity Capture-MS Homo sapiens
297 NUCKS1 64710
Affinity Capture-MS Homo sapiens
298 DNMT1 1786
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
299 FOXE1  
Affinity Capture-MS Homo sapiens
300 KIF4A 24137
Co-fractionation Homo sapiens
301 NOTCH1 4851
Affinity Capture-MS Homo sapiens
302 RANBP2 5903
Co-fractionation Homo sapiens
303 CDC5L 988
Affinity Capture-MS Homo sapiens
304 CPSF4  
Co-fractionation Homo sapiens
305 RAN 5901
Co-fractionation Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here