Gene description for HEATR1
Gene name HEAT repeat containing 1
Gene symbol HEATR1
Other names/aliases BAP28
UTP10
Species Homo sapiens
 Database cross references - HEATR1
ExoCarta ExoCarta_55127
Vesiclepedia VP_55127
Entrez Gene 55127
HGNC 25517
UniProt Q9H583  
 HEATR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for HEATR1
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    snoRNA binding GO:0030515 IBA
Biological Process
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000462 IBA
    rRNA metabolic process GO:0016072 IMP
    ribosomal small subunit biogenesis GO:0042274 IDA
    positive regulation of transcription by RNA polymerase I GO:0045943 IBA
    positive regulation of transcription by RNA polymerase I GO:0045943 IMP
    neural precursor cell proliferation GO:0061351 IMP
    protein localization to nucleolus GO:1902570 IDA
    positive regulation of rRNA processing GO:2000234 IMP
Subcellular Localization
    fibrillar center GO:0001650 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 IDA
    membrane GO:0016020 HDA
    90S preribosome GO:0030686 IBA
    small-subunit processome GO:0032040 IBA
    small-subunit processome GO:0032040 IDA
    t-UTP complex GO:0034455 IBA
 Experiment description of studies that identified HEATR1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
8
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HEATR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGOLN2 10618
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 NET1 10276
Affinity Capture-MS Homo sapiens
3 SGCA  
Affinity Capture-MS Homo sapiens
4 UTP15 84135
Co-fractionation Homo sapiens
5 LGR4 55366
Affinity Capture-MS Homo sapiens
6 LAMP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
8 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
9 VSIG8  
Affinity Capture-MS Homo sapiens
10 CDH5  
Affinity Capture-MS Homo sapiens
11 LRRC15 131578
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
13 SOX2  
Affinity Capture-MS Homo sapiens
14 NOP56 10528
Proximity Label-MS Homo sapiens
15 KIF20A 10112
Affinity Capture-MS Homo sapiens
16 TMEM9B 56674
Affinity Capture-MS Homo sapiens
17 VSTM1  
Affinity Capture-MS Homo sapiens
18 FAM174A 345757
Affinity Capture-MS Homo sapiens
19 PSMB8 5696
Co-fractionation Homo sapiens
20 DNAJB6 10049
Proximity Label-MS Homo sapiens
21 APEX1 328
Proximity Label-MS Homo sapiens
22 KIAA1429 25962
Affinity Capture-MS Homo sapiens
23 TSPYL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 DDX23 9416
Proximity Label-MS Homo sapiens
25 KIF23 9493
Affinity Capture-MS Homo sapiens
26 MCM2 4171
Affinity Capture-MS Homo sapiens
27 HLA-B 3106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 DGCR2 9993
Affinity Capture-MS Homo sapiens
29 DUSP14 11072
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PRC1 9055
Affinity Capture-MS Homo sapiens
31 SLC27A2 11001
Affinity Capture-MS Homo sapiens
32 FBL 2091
Proximity Label-MS Homo sapiens
33 POLR1E  
Proximity Label-MS Homo sapiens
34 OBSL1 23363
Affinity Capture-MS Homo sapiens
35 DDX58 23586
Affinity Capture-RNA Homo sapiens
36 P2RY10  
Affinity Capture-MS Homo sapiens
37 VAPB 9217
Affinity Capture-MS Homo sapiens
38 ITGA4 3676
Affinity Capture-MS Homo sapiens
39 ILK 3611
Affinity Capture-MS Homo sapiens
40 VCAM1 7412
Affinity Capture-MS Homo sapiens
41 F2RL1  
Affinity Capture-MS Homo sapiens
42 CA14 23632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 PSMB3 5691
Co-fractionation Homo sapiens
44 GPR17 2840
Affinity Capture-MS Homo sapiens
45 KIF14 9928
Affinity Capture-MS Homo sapiens
46 PROKR1  
Affinity Capture-MS Homo sapiens
47 BSG 682
Affinity Capture-MS Homo sapiens
48 Mgp 17313
Affinity Capture-MS Mus musculus
49 EEF1A1P5 158078
Cross-Linking-MS (XL-MS) Homo sapiens
50 CD70 970
Affinity Capture-MS Homo sapiens
51 HS2ST1 9653
Affinity Capture-MS Homo sapiens
52 ARHGEF39 84904
Affinity Capture-MS Homo sapiens
53 PELO 53918
Affinity Capture-MS Homo sapiens
54 STOM 2040
Affinity Capture-MS Homo sapiens
55 P2RY8  
Affinity Capture-MS Homo sapiens
56 SRSF3 6428
Co-fractionation Homo sapiens
57 XRN1 54464
Two-hybrid Homo sapiens
58 ILVBL 10994
Affinity Capture-MS Homo sapiens
59 NOL11  
Affinity Capture-MS Homo sapiens
60 VSIG4  
Affinity Capture-MS Homo sapiens
61 CBX3 11335
Proximity Label-MS Homo sapiens
62 COMTD1 118881
Affinity Capture-MS Homo sapiens
63 PTP4A3  
Affinity Capture-MS Homo sapiens
64 IL2RA  
Affinity Capture-MS Homo sapiens
65 VCP 7415
Affinity Capture-MS Homo sapiens
66 NTRK1 4914
Affinity Capture-MS Homo sapiens
67 RPL31 6160
Proximity Label-MS Homo sapiens
68 NPTN 27020
Affinity Capture-MS Homo sapiens
69 MAGED1 9500
Affinity Capture-MS Homo sapiens
70 GPR182  
Affinity Capture-MS Homo sapiens
71 HUWE1 10075
Affinity Capture-MS Homo sapiens
72 PML 5371
Affinity Capture-MS Homo sapiens
73 HECTD1 25831
Affinity Capture-MS Homo sapiens
74 SPN 6693
Affinity Capture-MS Homo sapiens
75 EED  
Affinity Capture-MS Homo sapiens
76 Bub1  
Affinity Capture-MS Mus musculus
77 DNTTIP2  
Cross-Linking-MS (XL-MS) Homo sapiens
78 GFAP 2670
Affinity Capture-MS Homo sapiens
79 MLNR  
Affinity Capture-MS Homo sapiens
80 CD3EAP  
Proximity Label-MS Homo sapiens
81 UPK2 7379
Affinity Capture-MS Homo sapiens
82 ANLN 54443
Affinity Capture-MS Homo sapiens
83 PHLPP1  
Proximity Label-MS Homo sapiens
84 FOXH1  
Affinity Capture-MS Homo sapiens
85 CD40 958
Affinity Capture-MS Homo sapiens
86 MGARP  
Affinity Capture-MS Homo sapiens
87 VIPR2  
Affinity Capture-MS Homo sapiens
88 GPR45  
Affinity Capture-MS Homo sapiens
89 FANCD2  
Affinity Capture-MS Homo sapiens
90 CUL3 8452
Affinity Capture-MS Homo sapiens
91 CHCHD1  
Proximity Label-MS Homo sapiens
92 ECT2 1894
Affinity Capture-MS Homo sapiens
93 SIRT7  
Affinity Capture-MS Homo sapiens
94 PSMD8 5714
Co-fractionation Homo sapiens
95 CD274 29126
Affinity Capture-MS Homo sapiens
96 FOXI1  
Affinity Capture-MS Homo sapiens
97 P2RY2 5029
Affinity Capture-MS Homo sapiens
98 FOXG1  
Affinity Capture-MS Homo sapiens
99 TNFRSF9  
Affinity Capture-MS Homo sapiens
100 PSMA2 5683
Co-fractionation Homo sapiens
101 EGFR 1956
Negative Genetic Homo sapiens
102 FOXL1  
Affinity Capture-MS Homo sapiens
103 IQCF1  
Affinity Capture-MS Homo sapiens
104 SUZ12  
Affinity Capture-MS Homo sapiens
105 Cep152  
Affinity Capture-MS Mus musculus
106 RPS27 6232
Affinity Capture-MS Homo sapiens
107 AAGAB  
Two-hybrid Homo sapiens
108 MYC  
Affinity Capture-MS Homo sapiens
109 RPA3 6119
Proximity Label-MS Homo sapiens
110 SELENBP1 8991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 DNAJC9 23234
Proximity Label-MS Homo sapiens
112 BRD4 23476
Affinity Capture-MS Homo sapiens
113 CD244 51744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 WDR75  
Affinity Capture-MS Homo sapiens
115 SCN2B  
Affinity Capture-MS Homo sapiens
116 DDRGK1 65992
Affinity Capture-MS Homo sapiens
117 RNF2  
Affinity Capture-MS Homo sapiens
118 BMI1  
Affinity Capture-MS Homo sapiens
119 FOXQ1  
Affinity Capture-MS Homo sapiens
120 SMC6  
Affinity Capture-MS Homo sapiens
121 TNFSF13B  
Affinity Capture-MS Homo sapiens
122 BRD3 8019
Affinity Capture-MS Homo sapiens
123 CCDC8  
Affinity Capture-MS Homo sapiens
124 HIF1A 3091
Affinity Capture-MS Homo sapiens
125 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
126 FASN 2194
Negative Genetic Homo sapiens
Positive Genetic Homo sapiens
127 ALDH3A2 224
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 TMEM9 252839
Affinity Capture-MS Homo sapiens
129 PARP1 142
Proximity Label-MS Homo sapiens
130 OPALIN  
Affinity Capture-MS Homo sapiens
131 MTMR3  
Affinity Capture-MS Homo sapiens
132 MFSD4  
Affinity Capture-MS Homo sapiens
133 FOXB1  
Affinity Capture-MS Homo sapiens
134 USP36  
Affinity Capture-MS Homo sapiens
135 CLEC2D  
Affinity Capture-MS Homo sapiens
136 Gnpnat1  
Affinity Capture-MS Mus musculus
137 TTBK1  
Affinity Capture-MS Homo sapiens
138 VPS52 6293
Two-hybrid Homo sapiens
139 EFNB1 1947
Affinity Capture-MS Homo sapiens
140 ITFG3 83986
Affinity Capture-MS Homo sapiens
141 SLAMF1 6504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 NIFK 84365
Proximity Label-MS Homo sapiens
143 GZMH  
Affinity Capture-MS Homo sapiens
144 PRAME  
Affinity Capture-MS Homo sapiens
145 LPCAT2 54947
Affinity Capture-MS Homo sapiens
146 RPS24 6229
Proximity Label-MS Homo sapiens
147 PSMA5 5686
Co-fractionation Homo sapiens
148 ARHGAP36  
Affinity Capture-MS Homo sapiens
149 C16orf72 29035
Affinity Capture-MS Homo sapiens
150 RPS6 6194
Proximity Label-MS Homo sapiens
151 VSIG1  
Affinity Capture-MS Homo sapiens
152 GRSF1 2926
Proximity Label-MS Homo sapiens
153 TPST2 8459
Affinity Capture-MS Homo sapiens
154 CUL7 9820
Affinity Capture-MS Homo sapiens
155 KRAS 3845
Negative Genetic Homo sapiens
156 P2RX2  
Affinity Capture-MS Homo sapiens
157 POLR1D 51082
Affinity Capture-MS Homo sapiens
158 HLA-C 3107
Affinity Capture-MS Homo sapiens
159 FOXE1  
Affinity Capture-MS Homo sapiens
160 PSMD3 5709
Co-fractionation Homo sapiens
View the network image/svg+xml



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