Gene description for IDH3B
Gene name isocitrate dehydrogenase 3 (NAD+) beta
Gene symbol IDH3B
Other names/aliases H-IDHB
RP46
Species Homo sapiens
 Database cross references - IDH3B
ExoCarta ExoCarta_3420
Entrez Gene 3420
HGNC 5385
MIM 604526
UniProt O43837  
 IDH3B identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IDH3B
Molecular Function
    isocitrate dehydrogenase (NAD+) activity GO:0004449 IEA
    NAD binding GO:0051287 IEA
    magnesium ion binding GO:0000287 IEA
    electron carrier activity GO:0009055 TAS
Biological Process
    cellular metabolic process GO:0044237 TAS
    2-oxoglutarate metabolic process GO:0006103 IEA
    small molecule metabolic process GO:0044281 TAS
    tricarboxylic acid cycle GO:0006099 TAS
    isocitrate metabolic process GO:0006102 IEA
    NADH metabolic process GO:0006734 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    mitochondrial matrix GO:0005759 TAS
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified IDH3B in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IDH3B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IDH3G  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 IDH3A 3419
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which IDH3B is involved
PathwayEvidenceSource
Citric acid cycle (TCA cycle) TAS Reactome





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