Gene description for ZRANB2
Gene name zinc finger, RAN-binding domain containing 2
Gene symbol ZRANB2
Other names/aliases ZIS
ZIS1
ZIS2
ZNF265
Species Homo sapiens
 Database cross references - ZRANB2
ExoCarta ExoCarta_9406
Vesiclepedia VP_9406
Entrez Gene 9406
HGNC 13058
MIM 604347
UniProt O95218  
 ZRANB2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ZRANB2
Molecular Function
    lipopolysaccharide binding GO:0001530 IBA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified ZRANB2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZRANB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CFAP20 29105
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 RPL26L1 51121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RSBN1L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 COIL  
Proximity Label-MS Homo sapiens
6 SRPK2 6733
Biochemical Activity Homo sapiens
7 YWHAE 7531
Co-fractionation Homo sapiens
8 HNRNPK 3190
Co-fractionation Homo sapiens
9 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
10 ACTC1 70
Proximity Label-MS Homo sapiens
11 USP39 10713
Affinity Capture-MS Homo sapiens
12 DHX8 1659
Proximity Label-MS Homo sapiens
13 ARL6IP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 KIF20A 10112
Two-hybrid Homo sapiens
15 TIGD6  
Affinity Capture-MS Homo sapiens
16 CSNK2A1 1457
Biochemical Activity Homo sapiens
17 DNAJC25 548645
Affinity Capture-MS Homo sapiens
18 RSBN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 DDX23 9416
Proximity Label-MS Homo sapiens
20 SNRNP70 6625
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
21 CORO1B 57175
Co-fractionation Homo sapiens
22 B3GNT2 10678
Affinity Capture-MS Homo sapiens
23 GTF2E2  
Affinity Capture-MS Homo sapiens
24 KIF23 9493
Affinity Capture-MS Homo sapiens
25 CDK11B 984
Co-fractionation Homo sapiens
26 C18orf25 147339
Co-fractionation Homo sapiens
27 NFKBIL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 OSBP 5007
Co-fractionation Homo sapiens
29 TRA2B 6434
Protein-RNA Homo sapiens
30 SRRM2 23524
Affinity Capture-MS Homo sapiens
31 PARVA 55742
Co-fractionation Homo sapiens
32 OBSL1 23363
Affinity Capture-MS Homo sapiens
33 LSM2 57819
Co-fractionation Homo sapiens
34 UBQLN1 29979
Co-fractionation Homo sapiens
35 PIP4K2B 8396
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 U2AF1 7307
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
37 ZNF644  
Co-fractionation Homo sapiens
38 SERF2 10169
Affinity Capture-MS Homo sapiens
39 MECP2 4204
Affinity Capture-MS Homo sapiens
40 MYCN  
Affinity Capture-MS Homo sapiens
41 SREK1 140890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 CTCF  
Affinity Capture-MS Homo sapiens
43 CCDC86  
Co-fractionation Homo sapiens
44 YWHAB 7529
Co-fractionation Homo sapiens
45 TBC1D17 79735
Co-fractionation Homo sapiens
46 UNK  
Co-fractionation Homo sapiens
47 EPB41L3 23136
Affinity Capture-MS Homo sapiens
48 LMNB1 4001
Co-fractionation Homo sapiens
49 PIP4K2C 79837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 UBE4B 10277
Co-fractionation Homo sapiens
51 RTF1 23168
Co-fractionation Homo sapiens
52 EMD 2010
Affinity Capture-MS Homo sapiens
53 PLD1 5337
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 ACIN1 22985
Affinity Capture-MS Homo sapiens
55 CBX3 11335
Proximity Label-MS Homo sapiens
56 RPL5 6125
Co-fractionation Homo sapiens
57 AKR7L 246181
Affinity Capture-MS Homo sapiens
58 SNRPD1 6632
Co-fractionation Homo sapiens
59 PMAIP1  
Affinity Capture-MS Homo sapiens
60 SWAP70 23075
Co-fractionation Homo sapiens
61 OGT 8473
Reconstituted Complex Homo sapiens
62 RPL31 6160
Proximity Label-MS Homo sapiens
63 ACTL6A 86
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 U2AF2 11338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 RAD18  
Affinity Capture-MS Homo sapiens
66 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
67 LUC7L2 51631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 TTC9C 283237
Co-fractionation Homo sapiens
69 ACTB 60
Co-fractionation Homo sapiens
70 MAGEB2 4113
Affinity Capture-MS Homo sapiens
71 KPNA5 3841
Affinity Capture-MS Homo sapiens
72 CEBPA  
Proximity Label-MS Homo sapiens
Protein-peptide Homo sapiens
73 SRPK1 6732
Biochemical Activity Homo sapiens
74 TTLL12 23170
Co-fractionation Homo sapiens
75 STAM 8027
Co-fractionation Homo sapiens
76 CD3EAP  
Proximity Label-MS Homo sapiens
77 ATG16L1 55054
Affinity Capture-MS Homo sapiens
78 PRPF4B 8899
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 FBXL7  
Affinity Capture-Western Homo sapiens
80 AHCYL1 10768
Co-fractionation Homo sapiens
81 RPL15 6138
Affinity Capture-MS Homo sapiens
82 NUBP2 10101
Co-fractionation Homo sapiens
83 TYMS 7298
Co-fractionation Homo sapiens
84 SRXN1 140809
Co-fractionation Homo sapiens
85 UBXN7 26043
Co-fractionation Homo sapiens
86 UBQLN2 29978
Co-fractionation Homo sapiens
87 SRSF11 9295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 SSB 6741
Co-fractionation Homo sapiens
90 BCCIP 56647
Co-fractionation Homo sapiens
91 SERPINB5 5268
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 MYC  
Affinity Capture-MS Homo sapiens
94 WDR60 55112
Affinity Capture-MS Homo sapiens
95 TOP1 7150
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 UBL7  
Co-fractionation Homo sapiens
97 DDRGK1 65992
Affinity Capture-MS Homo sapiens
98 LMNA 4000
Proximity Label-MS Homo sapiens
99 ARRB2 409
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
100 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
101 PAF1 54623
Co-fractionation Homo sapiens
102 TTC1 7265
Co-fractionation Homo sapiens
103 PARP1 142
Proximity Label-MS Homo sapiens
104 HDGF 3068
Affinity Capture-MS Homo sapiens
105 SAP130  
Co-fractionation Homo sapiens
106 USP34 9736
Co-fractionation Homo sapiens
107 PCMT1 5110
Co-fractionation Homo sapiens
108 SULT1A1 6817
Co-fractionation Homo sapiens
109 CDC37 11140
Co-fractionation Homo sapiens
110 UBA52 7311
Co-fractionation Homo sapiens
111 SMURF1 57154
Affinity Capture-MS Homo sapiens
112 EPHX1 2052
Co-fractionation Homo sapiens
113 G3BP1 10146
Co-fractionation Homo sapiens
114 UBE2C 11065
Co-fractionation Homo sapiens
115 EPB41L2 2037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 UCHL3 7347
Co-fractionation Homo sapiens
117 CDK1 983
Co-fractionation Homo sapiens
118 PSMA1 5682
Co-fractionation Homo sapiens
119 ATP6V1F 9296
Co-fractionation Homo sapiens
120 HDGFRP2 84717
Co-fractionation Homo sapiens
121 RIOK2 55781
Co-fractionation Homo sapiens
122 UBE2B 7320
Co-fractionation Homo sapiens
123 ARRB1 408
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
124 SRSF7 6432
Co-fractionation Homo sapiens
125 SSSCA1 10534
Co-fractionation Homo sapiens
126 METTL3  
Affinity Capture-MS Homo sapiens
127 SERBP1 26135
Affinity Capture-MS Homo sapiens
128 CUL7 9820
Affinity Capture-MS Homo sapiens
129 RC3H1 149041
Affinity Capture-MS Homo sapiens
130 VANGL1 81839
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 PTCH1  
Affinity Capture-MS Homo sapiens
132 RPA3 6119
Proximity Label-MS Homo sapiens
133 LUC7L 55692
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 UBE2V2 7336
Co-fractionation Homo sapiens
135 LUC7L3 51747
Affinity Capture-MS Homo sapiens
136 PLCD3 113026
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZRANB2 is involved
No pathways found





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