Gene description for TPR
Gene name	translocated promoter region, nuclear basket protein
Gene symbol	TPR
Other names/aliases	-
Species	Homo sapiens
Database cross references - TPR
ExoCarta	ExoCarta_7175
Entrez Gene	7175
HGNC	12017
MIM	189940
UniProt	P12270
TPR identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for TPR

Molecular Function     protein anchor GO:0043495 IMP     nucleocytoplasmic transporter activity GO:0005487 IDA     protein homodimerization activity GO:0042803 IDA     molecular_function GO:0003674 ND     mRNA binding GO:0003729 IDA     poly(A) RNA binding GO:0044822 IDA     heat shock protein binding GO:0031072 IDA     protein binding GO:0005515 IPI     transporter activity GO:0005215 IMP     dynein complex binding GO:0070840 IDA     tubulin binding GO:0015631 IDA     mitogen-activated protein kinase binding GO:0051019 IDA     chromatin binding GO:0003682 IDA Biological Process     negative regulation of RNA export from nucleus GO:0046832 IMP     positive regulation of heterochromatin assembly GO:0031453 IMP     carbohydrate metabolic process GO:0005975 TAS     positive regulation of protein export from nucleus GO:0046827 ISS     mitotic cell cycle GO:0000278 TAS     viral life cycle GO:0019058 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     viral process GO:0016032 TAS     protein sumoylation GO:0016925 TAS     negative regulation of translational initiation GO:0045947 IMP     biological_process GO:0008150 ND     regulation of cellular response to heat GO:1900034 TAS     protein import into nucleus GO:0006606 IMP     regulation of protein stability GO:0031647 IMP     regulation of glucose transport GO:0010827 TAS     nuclear pore organization GO:0006999 IMP     cellular response to heat GO:0034605 TAS     hexose transport GO:0008645 TAS     mRNA export from nucleus in response to heat stress GO:0031990 IDA     cytokine-mediated signaling pathway GO:0019221 TAS     RNA import into nucleus GO:0006404 IDA     MAPK import into nucleus GO:0000189 IMP     positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 IMP     nuclear pore complex assembly GO:0051292 IMP     mitotic nuclear envelope disassembly GO:0007077 TAS     RNA export from nucleus GO:0006405 IMP     nuclear matrix organization GO:0043578 IMP     regulation of mitotic spindle assembly GO:1901673 IMP     cellular protein metabolic process GO:0044267 TAS     post-translational protein modification GO:0043687 TAS     positive regulation of protein import into nucleus GO:0042307 IMP     viral transcription GO:0019083 TAS     regulation of protein import into nucleus GO:0042306 IMP     cell division GO:0051301 IEA     positive regulation of intracellular protein transport GO:0090316 IMP     small molecule metabolic process GO:0044281 TAS     response to epidermal growth factor GO:0070849 IDA     cellular response to interferon-alpha GO:0035457 ISS     regulation of mitotic sister chromatid separation GO:0010965 IMP     gene expression GO:0010467 TAS     regulation of mRNA export from nucleus GO:0010793 IMP     protein export from nucleus GO:0006611 IMP     mitotic nuclear division GO:0007067 IEA     glucose transport GO:0015758 TAS     transmembrane transport GO:0055085 TAS     regulation of protein export from nucleus GO:0046825 IMP     mitotic spindle assembly checkpoint GO:0007094 IMP Subcellular Localization     mitotic spindle GO:0072686 IDA     nuclear inclusion body GO:0042405 IDA     cytoplasmic dynein complex GO:0005868 IDA     nuclear periphery GO:0034399 IDA     nuclear membrane GO:0031965 IDA     nuclear pore GO:0005643 IDA     nucleoplasm GO:0005654 TAS     nuclear pore nuclear basket GO:0044615 IDA     nuclear envelope GO:0005635 IDA     nucleus GO:0005634 IDA     extrinsic component of membrane GO:0019898 IDA     cytoplasm GO:0005737 IDA     kinetochore GO:0000776 IDA     cellular_component GO:0005575 ND