Gene description for SUMO1
Gene name small ubiquitin-like modifier 1
Gene symbol SUMO1
Other names/aliases DAP1
GMP1
OFC10
PIC1
SENP2
SMT3
SMT3C
SMT3H3
UBL1
Species Homo sapiens
 Database cross references - SUMO1
ExoCarta ExoCarta_7341
Entrez Gene 7341
HGNC 12502
MIM 601912
UniProt P63165  
 SUMO1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SUMO1
Molecular Function
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    transcription factor binding GO:0008134 ISS
    SUMO transferase activity GO:0019789 IEA
    ubiquitin protein ligase binding GO:0031625 IPI
    potassium channel regulator activity GO:0015459 IDA
    ion channel binding GO:0044325 IPI
Biological Process
    negative regulation of DNA binding GO:0043392 IMP
    protein sumoylation GO:0016925 TAS
    cellular protein metabolic process GO:0044267 TAS
    negative regulation of delayed rectifier potassium channel activity GO:1902260 IDA
    PML body organization GO:0030578 IEA
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IMP
    palate development GO:0060021 ISS
    regulation of interferon-gamma-mediated signaling pathway GO:0060334 TAS
    DNA repair GO:0006281 TAS
    post-translational protein modification GO:0043687 TAS
    positive regulation of protein complex assembly GO:0031334 IDA
    regulation of protein localization GO:0032880 TAS
    cytokine-mediated signaling pathway GO:0019221 TAS
    interferon-gamma-mediated signaling pathway GO:0060333 TAS
    protein localization to nuclear pore GO:0090204 IEA
    negative regulation of action potential GO:0045759 IDA
    negative regulation of transcription, DNA-templated GO:0045892 IMP
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IDA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    dendrite GO:0030425 IEA
    synapse GO:0045202 IEA
    nuclear membrane GO:0031965 IDA
    nuclear speck GO:0016607 IEA
    plasma membrane GO:0005886 IDA
    voltage-gated potassium channel complex GO:0008076 IDA
    PML body GO:0016605 IDA
    nucleolus GO:0005730 IDA
    fibrillar center GO:0001650 IEA
    nuclear pore GO:0005643 TAS
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified SUMO1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SUMO1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FASLG 356
Two-hybrid Homo sapiens
2 CD40 958
Two-hybrid Homo sapiens
3 FADD 8772
Two-hybrid Homo sapiens
4 MITF  
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
5 TOE1 114034
Two-hybrid Homo sapiens
6 SP100  
Two-hybrid Homo sapiens
7 CHD3  
Two-hybrid Homo sapiens
8 FAS 355
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
9 DAXX  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 TOP2B 7155
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
11 PIAS2  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
12 RAD52  
Two-hybrid Homo sapiens
13 HIPK3 10114
Two-hybrid Homo sapiens
14 SENP2  
Invivo Homo sapiens
Invitro Homo sapiens
15 TNFRSF1A 7132
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
16 NR3C1 2908
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
17 HEX3  
Reconstituted Complex 4932
18 SAE1 10055
Reconstituted Complex Homo sapiens
19 SALL1 6299
Invitro Homo sapiens
Two-hybrid Homo sapiens
20 TP73  
Two-hybrid Homo sapiens
21 TOP2A 7153
Invivo Homo sapiens
Invitro Homo sapiens
22 UBE2I 7329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
23 STAB2 55576
Biochemical Activity Homo sapiens
24 DNMT3B  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
25 UBA2 10054
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
26 PIAS1 8554
Invitro Homo sapiens
Two-hybrid Homo sapiens
27 MGC33948  
Two-hybrid Homo sapiens
28 PML  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
29 TP53  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
30 TOP1 7150
Invivo Homo sapiens
31 TOPORS  
Two-hybrid Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
32 HIPK2 28996
Two-hybrid Homo sapiens
33 TDP2 51567
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
34 TDG 6996
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
35 RAD51  
Invivo Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
36 RANGAP1 5905
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
37 SUMO1 7341
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
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