Gene description for GRN
Gene name granulin
Gene symbol GRN
Other names/aliases CLN11
GEP
GP88
PCDGF
PEPI
PGRN
Species Homo sapiens
 Database cross references - GRN
ExoCarta ExoCarta_2896
Vesiclepedia VP_2896
Entrez Gene 2896
HGNC 4601
MIM 138945
UniProt P28799  
 GRN identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for GRN
Molecular Function
    RNA binding GO:0003723 HDA
    cytokine activity GO:0005125 IEA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 TAS
    protein-folding chaperone binding GO:0051087 IDA
Biological Process
    astrocyte activation involved in immune response GO:0002265 ISS
    microglial cell activation involved in immune response GO:0002282 ISS
    lysosome organization GO:0007040 ISS
    lysosomal transport GO:0007041 IMP
    lysosomal transport GO:0007041 ISS
    lysosomal lumen acidification GO:0007042 IMP
    signal transduction GO:0007165 NAS
    positive regulation of endothelial cell migration GO:0010595 ISS
    positive regulation of cell migration GO:0030335 IMP
    negative regulation of neuron apoptotic process GO:0043524 IDA
    positive regulation of neuron apoptotic process GO:0043525 ISS
    positive regulation of angiogenesis GO:0045766 ISS
    positive regulation of axon regeneration GO:0048680 ISS
    positive regulation of epithelial cell proliferation GO:0050679 IDA
    regulation of inflammatory response GO:0050727 IBA
    protein stabilization GO:0050821 IMP
    negative regulation of respiratory burst involved in inflammatory response GO:0060266 IDA
    positive regulation of inflammatory response to wounding GO:0106016 ISS
    positive regulation of defense response to bacterium GO:1900426 ISS
    negative regulation of neutrophil activation GO:1902564 IDA
    positive regulation of protein folding GO:1903334 ISS
    negative regulation of microglial cell activation GO:1903979 ISS
    positive regulation of aspartic-type peptidase activity GO:1905247 IMP
    positive regulation of aspartic-type peptidase activity GO:1905247 ISS
    positive regulation of lysosome organization GO:1905673 IDA
Subcellular Localization
    extracellular region GO:0005576 IBA
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 IDA
    endosome GO:0005768 IDA
    late endosome GO:0005770 IDA
    endoplasmic reticulum GO:0005783 IDA
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 ISS
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 IDA
    azurophil granule lumen GO:0035578 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified GRN in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
13
Experiment ID 136
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name PC3 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
14
Experiment ID 137
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB6|CD10
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name PC3 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
15
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for GRN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDCD6 10016
Affinity Capture-MS Homo sapiens
2 OTUD5 55593
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 XIAP  
Affinity Capture-MS Homo sapiens
4 CACNG5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 POT1  
Two-hybrid Homo sapiens
6 CD68 968
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 DCP1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PKP2 5318
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 BTF3 689
Affinity Capture-MS Homo sapiens
10 FGF4  
Affinity Capture-MS Homo sapiens
11 FAM43A  
Affinity Capture-MS Homo sapiens
12 MIIP 60672
Affinity Capture-MS Homo sapiens
13 BGLAP  
Affinity Capture-MS Homo sapiens
14 LGALS1 3956
Affinity Capture-MS Homo sapiens
15 TLE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 VHL  
Affinity Capture-MS Homo sapiens
17 ZC3HC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SLURP1  
Affinity Capture-MS Homo sapiens
19 ATN1  
Two-hybrid Homo sapiens
20 PKMYT1  
Affinity Capture-MS Homo sapiens
21 SLPI 6590
Affinity Capture-Western Homo sapiens
22 MFAP5  
Affinity Capture-MS Homo sapiens
23 INTS9 55756
Affinity Capture-MS Homo sapiens
24 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
25 CCDC69 26112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 DLX2  
Two-hybrid Homo sapiens
28 ZSCAN21  
Affinity Capture-MS Homo sapiens
29 ZNF512B  
Affinity Capture-MS Homo sapiens
30 NAPSA 9476
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 SGTA 6449
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 KRT31 3881
Two-hybrid Homo sapiens
33 POLRMT 5442
Affinity Capture-MS Homo sapiens
34 SNRNP48  
Two-hybrid Homo sapiens
35 FAM207A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 C2orf44  
Affinity Capture-MS Homo sapiens
37 EED  
Affinity Capture-MS Homo sapiens
38 PLA2G10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ATG16L1 55054
Affinity Capture-MS Homo sapiens
40 YY1 7528
Two-hybrid Homo sapiens
41 PSMC6 5706
Affinity Capture-MS Homo sapiens
42 MYCN  
Affinity Capture-MS Homo sapiens
43 PSAP 5660
Affinity Capture-MS Homo sapiens
44 GBX1  
Affinity Capture-MS Homo sapiens
45 GFI1B  
Two-hybrid Homo sapiens
46 NOTCH2 4853
Affinity Capture-MS Homo sapiens
47 C1orf106  
Affinity Capture-MS Homo sapiens
48 SERPING1 710
Affinity Capture-MS Homo sapiens
49 NF2 4771
Affinity Capture-MS Homo sapiens
50 HRG 3273
Affinity Capture-MS Homo sapiens
51 TOP3B 8940
Two-hybrid Homo sapiens
52 CRY1  
Two-hybrid Homo sapiens
53 TGM2 7052
Two-hybrid Homo sapiens
54 PARK2  
Affinity Capture-MS Homo sapiens
55 CST6  
Affinity Capture-MS Homo sapiens
56 MSX2  
Affinity Capture-MS Homo sapiens
57 CCDC33 80125
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
58 CTSO  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 ABI2 10152
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 FAM19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 VCP 7415
Affinity Capture-MS Homo sapiens
63 TRIM21 6737
Affinity Capture-MS Homo sapiens
64 NTRK1 4914
Affinity Capture-MS Homo sapiens
65 CRKL 1399
Two-hybrid Homo sapiens
66 DCP1A 55802
Affinity Capture-MS Homo sapiens
67 FAM131C  
Two-hybrid Homo sapiens
68 RLIM 51132
Affinity Capture-MS Homo sapiens
69 PPP2CA 5515
Affinity Capture-MS Homo sapiens
70 MAPK3 5595
Affinity Capture-MS Homo sapiens
71 CELA2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 IGFL3  
Affinity Capture-MS Homo sapiens
73 Hk3  
Two-hybrid Rattus norvegicus
Reconstituted Complex Rattus norvegicus
Reconstituted Complex Rattus norvegicus
74 NLK  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
75 ARFGAP1 55738
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
76 CCNT1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
77 RPS6KA1 6195
Affinity Capture-MS Homo sapiens
78 KRTAP10-7  
Two-hybrid Homo sapiens
79 Nufip2  
Two-hybrid Mus musculus
80 FBXO45 200933
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 TAT  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
82 CACNA1A  
Two-hybrid Homo sapiens
83 DEFA1 1667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 CTU1 90353
Affinity Capture-MS Homo sapiens
85 AHCYL1 10768
Affinity Capture-MS Homo sapiens
86 DEFB110  
Affinity Capture-MS Homo sapiens
87 PHLPP2  
Affinity Capture-MS Homo sapiens
88 CUL3 8452
Affinity Capture-MS Homo sapiens
89 UNG  
Co-fractionation Homo sapiens
90 PEF1 553115
Affinity Capture-MS Homo sapiens
91 EGFR 1956
Affinity Capture-MS Homo sapiens
92 IGFL1 374918
Affinity Capture-MS Homo sapiens
93 WFDC2  
Affinity Capture-MS Homo sapiens
94 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 ATP1B3 483
Affinity Capture-MS Homo sapiens
96 HOXA1 3198
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
97 OTX1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
98 ADAMTSL1 92949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 NXF1 10482
Affinity Capture-RNA Homo sapiens
100 Hoxa1  
Two-hybrid Mus musculus
101 EGFL7 51162
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 CDK2 1017
Affinity Capture-MS Homo sapiens
103 FAM122B  
Affinity Capture-MS Homo sapiens
104 OBFC1 79991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 MYC  
Affinity Capture-MS Homo sapiens
106 HECW2  
Affinity Capture-MS Homo sapiens
107 SMAD9  
Two-hybrid Homo sapiens
108 KLK3  
Affinity Capture-MS Homo sapiens
109 FBXO2 26232
Affinity Capture-MS Homo sapiens
110 COX6B1 1340
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 SAV1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 CLEC4M  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 FRAT1 10023
Two-hybrid Homo sapiens
114 DNAJC10 54431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 CCNG1  
Two-hybrid Homo sapiens
116 PCM1 5108
Two-hybrid Homo sapiens
117 PRKAB2 5565
Two-hybrid Homo sapiens
118 C7orf60 154743
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 SIRT3  
Affinity Capture-MS Homo sapiens
120 CCDC8  
Affinity Capture-MS Homo sapiens
121 KRT18 3875
Two-hybrid Homo sapiens
122 ALG13 79868
Two-hybrid Homo sapiens
123 PDLIM7 9260
Affinity Capture-MS Homo sapiens
124 SPRY2 10253
Two-hybrid Homo sapiens
125 FOLR1 2348
Affinity Capture-MS Homo sapiens
126 ASIP  
Affinity Capture-MS Homo sapiens
127 LDLRAD1  
Affinity Capture-MS Homo sapiens
128 EPHA7 2045
Affinity Capture-MS Homo sapiens
129 ATXN7  
Two-hybrid Homo sapiens
130 SLC39A7 7922
Affinity Capture-MS Homo sapiens
131 KLF3  
Proximity Label-MS Homo sapiens
132 SPACA4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 DLK1  
Two-hybrid Homo sapiens
134 EDC3 80153
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 CELA3B  
Affinity Capture-MS Homo sapiens
136 MAPK1 5594
Affinity Capture-MS Homo sapiens
137 AHCYL2 23382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 TRIM37  
Proximity Label-MS Homo sapiens
139 KRTAP26-1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
140 FLYWCH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 NAB2 4665
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 CDK9 1025
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
143 ZNF517  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 TRIB3  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
145 GLRX3 10539
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
146 PIK3R2 5296
Two-hybrid Homo sapiens
147 CUL7 9820
Affinity Capture-MS Homo sapiens
148 FANCL 55120
Two-hybrid Homo sapiens
149 RAC1 5879
Two-hybrid Homo sapiens
150 RAPGEF6 51735
Affinity Capture-MS Homo sapiens
151 AGRP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 NIN 51199
Proximity Label-MS Homo sapiens
153 NEDD8 4738
Reconstituted Complex Homo sapiens
154 EP300 2033
Affinity Capture-MS Homo sapiens
155 GNB2 2783
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GRN is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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