Gene description for EMC1
Gene name ER membrane protein complex subunit 1
Gene symbol EMC1
Other names/aliases KIAA0090
Species Homo sapiens
 Database cross references - EMC1
ExoCarta ExoCarta_23065
Vesiclepedia VP_23065
Entrez Gene 23065
HGNC 28957
UniProt Q8N766  
 EMC1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for EMC1
Molecular Function
    protein binding GO:0005515 IPI
    membrane insertase activity GO:0032977 IMP
Biological Process
    protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0045050 IDA
    protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0045050 IMP
    tail-anchored membrane protein insertion into ER membrane GO:0071816 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 NAS
    membrane GO:0016020 IDA
    protein-containing complex GO:0032991 IDA
    EMC complex GO:0072546 IBA
    EMC complex GO:0072546 IDA
    EMC complex GO:0072546 IPI
    EMC complex GO:0072546 ISS
 Experiment description of studies that identified EMC1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for EMC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 NOMO1 23420
Affinity Capture-MS Homo sapiens
3 ISG15 9636
Affinity Capture-MS Homo sapiens
4 DERL2 51009
Affinity Capture-MS Homo sapiens
5 TMED5 50999
Affinity Capture-MS Homo sapiens
6 CTDNEP1 23399
Proximity Label-MS Homo sapiens
7 NOP56 10528
Proximity Label-MS Homo sapiens
8 HSPA13 6782
Proximity Label-MS Homo sapiens
9 PLD4  
Affinity Capture-MS Homo sapiens
10 VSTM1  
Affinity Capture-MS Homo sapiens
11 DNAJC25 548645
Proximity Label-MS Homo sapiens
12 PTPN1 5770
Proximity Label-MS Homo sapiens
13 COPA 1314
Affinity Capture-MS Homo sapiens
14 PDE2A  
Affinity Capture-MS Homo sapiens
15 ILF2 3608
Co-fractionation Homo sapiens
16 FIS1 51024
Proximity Label-MS Homo sapiens
17 HSPA5 3309
Proximity Label-MS Homo sapiens
18 APOC3 345
Affinity Capture-MS Homo sapiens
19 Emc3  
Affinity Capture-MS Mus musculus
20 TRDN 10345
Affinity Capture-MS Homo sapiens
21 TMED2 10959
Affinity Capture-MS Homo sapiens
22 ST14 6768
Affinity Capture-MS Homo sapiens
23 ARMCX3 51566
Co-fractionation Homo sapiens
24 DDOST 1650
Affinity Capture-MS Homo sapiens
25 DNAJC16  
Proximity Label-MS Homo sapiens
26 SLC25A46 91137
Proximity Label-MS Homo sapiens
27 MECP2 4204
Affinity Capture-MS Homo sapiens
28 FAF2 23197
Affinity Capture-MS Homo sapiens
29 HK1 3098
Co-fractionation Homo sapiens
30 EMC9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 NDFIP1 80762
Affinity Capture-MS Homo sapiens
32 DNAJC14  
Proximity Label-MS Homo sapiens
33 LRRC59 55379
Proximity Label-MS Homo sapiens
34 EMC10 284361
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ATP1B4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 POTEF 728378
Affinity Capture-MS Homo sapiens
37 ADPGK 83440
Affinity Capture-MS Homo sapiens
38 RB1CC1 9821
Affinity Capture-MS Homo sapiens
39 PARK2  
Affinity Capture-MS Homo sapiens
40 COPE 11316
Affinity Capture-MS Homo sapiens
41 OR4N2  
Affinity Capture-MS Homo sapiens
42 UBAC2 337867
Affinity Capture-MS Homo sapiens
43 APOA2 336
Affinity Capture-MS Homo sapiens
44 DNAJB9 4189
Proximity Label-MS Homo sapiens
45 ENO1 2023
Affinity Capture-MS Homo sapiens
46 BTNL3  
Affinity Capture-MS Homo sapiens
47 DNAJC30  
Proximity Label-MS Homo sapiens
48 RHOT2 89941
Proximity Label-MS Homo sapiens
49 CCDC47 57003
Affinity Capture-MS Homo sapiens
50 VDAC2 7417
Affinity Capture-MS Homo sapiens
51 SEC61B 10952
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 TMPRSS13  
Affinity Capture-MS Homo sapiens
53 DNAJB11 51726
Proximity Label-MS Homo sapiens
54 ZACN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 RMDN3 55177
Proximity Label-MS Homo sapiens
56 COX4I1 1327
Proximity Label-MS Homo sapiens
57 SPPL3  
Affinity Capture-MS Homo sapiens
58 P2RX4 5025
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SEC63 11231
Proximity Label-MS Homo sapiens
60 NTRK1 4914
Affinity Capture-MS Homo sapiens
61 RPL32 6161
Affinity Capture-MS Homo sapiens
62 TMED9 54732
Affinity Capture-MS Homo sapiens
63 EMC3 55831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 CANX 821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 DNAJB12 54788
Proximity Label-MS Homo sapiens
66 EMC8 10328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 CALR3  
Proximity Label-MS Homo sapiens
68 PON2 5445
Affinity Capture-MS Homo sapiens
69 CD274 29126
Affinity Capture-MS Homo sapiens
70 BCAP31 10134
Proximity Label-MS Homo sapiens
71 CUL3 8452
Affinity Capture-MS Homo sapiens
72 FKBP8 23770
Proximity Label-MS Homo sapiens
73 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 ATP1B3 483
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 EPHA7 2045
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 RPA3 6119
Proximity Label-MS Homo sapiens
77 FBXO2 26232
Affinity Capture-MS Homo sapiens
78 EMC2 9694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 NCLN 56926
Affinity Capture-MS Homo sapiens
80 DNAJC10 54431
Proximity Label-MS Homo sapiens
81 DNAJC3 5611
Proximity Label-MS Homo sapiens
82 CUL7 9820
Affinity Capture-MS Homo sapiens
83 LMNA 4000
Proximity Label-MS Homo sapiens
84 AKAP1 8165
Proximity Label-MS Homo sapiens
85 FLOT1 10211
Co-fractionation Homo sapiens
86 EMC6 83460
Affinity Capture-MS Homo sapiens
87 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
88 TMED10 10972
Affinity Capture-MS Homo sapiens
89 ILF3 3609
Co-fractionation Homo sapiens
90 TP53 7157
Affinity Capture-MS Homo sapiens
91 SCGB1D1  
Affinity Capture-MS Homo sapiens
92 PDIA4 9601
Proximity Label-MS Homo sapiens
93 CALU 813
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
94 EMC7 56851
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 TPTE  
Proximity Label-MS Homo sapiens
96 TMEM120B  
Affinity Capture-MS Homo sapiens
97 EMC4 51234
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 SCGB1C1  
Affinity Capture-MS Homo sapiens
99 NUP35 129401
Proximity Label-MS Homo sapiens
100 OGDHL  
Affinity Capture-MS Homo sapiens
101 MMGT1 93380
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 PLD3 23646
Affinity Capture-MS Homo sapiens
103 TSC22D1 8848
Affinity Capture-MS Homo sapiens
104 RAB7A 7879
Proximity Label-MS Homo sapiens
105 KLHL22 84861
Affinity Capture-MS Homo sapiens
106 STT3B 201595
Affinity Capture-MS Homo sapiens
107 DNAJC1 64215
Proximity Label-MS Homo sapiens
108 KRAS 3845
Negative Genetic Homo sapiens
109 C9orf72  
Affinity Capture-MS Homo sapiens
110 PLD6  
Affinity Capture-MS Homo sapiens
111 EP300 2033
Affinity Capture-MS Homo sapiens
112 DERL1 79139
Affinity Capture-MS Homo sapiens
113 DNAJC22  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which EMC1 is involved
No pathways found





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