Gene description for UBE2D1
Gene name ubiquitin-conjugating enzyme E2D 1
Gene symbol UBE2D1
Other names/aliases E2(17)KB1
SFT
UBC4/5
UBCH5
UBCH5A
Species Homo sapiens
 Database cross references - UBE2D1
ExoCarta ExoCarta_7321
Vesiclepedia VP_7321
Entrez Gene 7321
HGNC 12474
MIM 602961
UniProt P51668  
 UBE2D1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for UBE2D1
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    ubiquitin-protein transferase activity GO:0004842 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ubiquitin protein ligase activity GO:0061630 IDA
    ubiquitin conjugating enzyme activity GO:0061631 IBA
    ubiquitin conjugating enzyme activity GO:0061631 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 TAS
    protein polyubiquitination GO:0000209 IDA
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    negative regulation of BMP signaling pathway GO:0030514 TAS
    positive regulation of protein ubiquitination GO:0031398 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA
    protein K48-linked ubiquitination GO:0070936 IBA
    protein K48-linked ubiquitination GO:0070936 IDA
    positive regulation of protein polyubiquitination GO:1902916 IEA
    negative regulation of TORC1 signaling GO:1904262 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified UBE2D1 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UBE2D1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
2 KLHL9 55958
Reconstituted Complex Homo sapiens
3 RING1 6015
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
4 Stat5a  
Biochemical Activity Mus musculus
5 TNFAIP3 7128
Reconstituted Complex Homo sapiens
6 CRBN  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
7 STAM2 10254
Biochemical Activity Homo sapiens
8 UTRN 7402
Co-fractionation Homo sapiens
9 XIAP  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
10 RNF122  
Reconstituted Complex Homo sapiens
11 MCM2 4171
Affinity Capture-MS Homo sapiens
12 SIAH2 6478
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
13 RNF167 26001
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
14 WWP1 11059
Reconstituted Complex Homo sapiens
15 MARCH7  
Two-hybrid Homo sapiens
16 GADD45A  
Two-hybrid Homo sapiens
17 TRIM35 23087
Two-hybrid Homo sapiens
18 BRMS1 25855
Reconstituted Complex Homo sapiens
19 RNF25 64320
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
20 MARCH2  
Reconstituted Complex Homo sapiens
21 SH3RF1  
Reconstituted Complex Homo sapiens
22 UBA1 7317
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
23 BRCA1 672
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
24 EPS15 2060
Biochemical Activity Homo sapiens
25 UBE3A 7337
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
26 USP9X 8239
Co-fractionation Homo sapiens
Co-purification Homo sapiens
27 UBC 7316
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
28 CHFR  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
29 SH3BGRL2  
Co-fractionation Homo sapiens
30 VHL  
Reconstituted Complex Homo sapiens
31 TRIM55  
Two-hybrid Homo sapiens
32 MID1 4281
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 Rag1  
Reconstituted Complex Mus musculus
34 RFFL 117584
Reconstituted Complex Homo sapiens
35 RCHY1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
36 Trim21  
Reconstituted Complex Rattus norvegicus
37 IGBP1 3476
Co-fractionation Homo sapiens
38 TRIM28 10155
Reconstituted Complex Homo sapiens
39 DTX3  
Two-hybrid Homo sapiens
40 RNF5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 PELI1 57162
Reconstituted Complex Homo sapiens
42 CADPS2  
Two-hybrid Homo sapiens
43 TRAIP  
Reconstituted Complex Homo sapiens
44 POLL  
Biochemical Activity Homo sapiens
45 TBL1XR1 79718
Affinity Capture-Western Homo sapiens
46 MYLIP  
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
47 RNF8  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
48 UBE2B 7320
Co-fractionation Homo sapiens
49 FZR1  
Reconstituted Complex Homo sapiens
50 TRIM50  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
51 BRCC3 79184
Reconstituted Complex Homo sapiens
52 UBOX5  
Two-hybrid Homo sapiens
53 TMEM129  
Reconstituted Complex Homo sapiens
54 ASB9  
Reconstituted Complex Homo sapiens
55 MARCH5  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
56 Zswim2  
Affinity Capture-Western Mus musculus
57 TOM1 10043
Reconstituted Complex Homo sapiens
58 ANAPC11  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
59 YAP1 10413
Co-fractionation Homo sapiens
60 MKRN3  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
61 MID2 11043
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
62 LRSAM1 90678
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
63 ASB4  
Reconstituted Complex Homo sapiens
64 TRIM26 7726
Two-hybrid Homo sapiens
65 APEX1 328
Affinity Capture-RNA Homo sapiens
66 BIRC3 330
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
67 POLM  
Biochemical Activity Homo sapiens
68 RNF126  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
69 BTRC 8945
Affinity Capture-Western Homo sapiens
70 ARIH2 10425
Two-hybrid Homo sapiens
71 CDC5L 988
Affinity Capture-MS Homo sapiens
72 FAF2 23197
Reconstituted Complex Homo sapiens
73 NEDD4 4734
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
74 ATP6V1F 9296
Co-fractionation Homo sapiens
75 RNF207  
Reconstituted Complex Homo sapiens
76 BFAR  
Two-hybrid Homo sapiens
77 GSK3B 2932
Two-hybrid Homo sapiens
78 RNF11 26994
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
79 RNF115  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
80 TRIM8  
Two-hybrid Homo sapiens
81 WDR1 9948
Co-fractionation Homo sapiens
82 TRAF4 9618
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
83 UNK  
Co-fractionation Homo sapiens
84 RABGEF1 27342
Reconstituted Complex Homo sapiens
85 TRIM24  
Reconstituted Complex Homo sapiens
86 ANXA7 310
Two-hybrid Homo sapiens
87 RNF6  
Reconstituted Complex Homo sapiens
88 RNF165  
Two-hybrid Homo sapiens
89 MIB1 57534
Two-hybrid Homo sapiens
90 UBE4B 10277
Co-fractionation Homo sapiens
91 SHPRH  
Reconstituted Complex Homo sapiens
92 RNF4 6047
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
93 TRIM7  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
94 RBX1 9978
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-RNA Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
95 CDKN1A  
Two-hybrid Homo sapiens
96 NEURL1  
Reconstituted Complex Homo sapiens
97 NR1H2  
Two-hybrid Homo sapiens
98 AMFR 267
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
99 DTX1  
Two-hybrid Homo sapiens
100 BRE 9577
Reconstituted Complex Homo sapiens
101 THRSP  
Affinity Capture-MS Homo sapiens
102 NBN 4683
Reconstituted Complex Homo sapiens
103 CBL 867
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
104 CNOT4 4850
Reconstituted Complex Homo sapiens
105 RNF146  
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
106 ZNRF2 223082
Two-hybrid Homo sapiens
107 UBASH3B 84959
Biochemical Activity Homo sapiens
108 RAG1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
109 EP300 2033
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
110 MKRN2 23609
Two-hybrid Homo sapiens
111 PMAIP1  
Reconstituted Complex Homo sapiens
112 BARD1 580
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
113 TRIM21 6737
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
114 RNF166  
Two-hybrid Homo sapiens
115 RNF123 63891
Affinity Capture-MS Homo sapiens
116 HERC2 8924
Reconstituted Complex Homo sapiens
117 DTX2 113878
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
118 RLIM 51132
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
119 F12  
Reconstituted Complex Homo sapiens
120 TRIM32 22954
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
121 KLHL2 11275
Reconstituted Complex Homo sapiens
122 TRIM11  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
123 MARCH8  
Reconstituted Complex Homo sapiens
124 RNF13 11342
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
125 UBE2D3 7323
Affinity Capture-MS Homo sapiens
126 HECTD1 25831
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
127 CUL2 8453
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
128 RNF125  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
129 TRIM17  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
130 SIVA1  
Reconstituted Complex Homo sapiens
131 ITCH 83737
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
132 TNNT1  
Two-hybrid Homo sapiens
133 TRIM63  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
134 HIF1A 3091
Biochemical Activity Homo sapiens
135 TTLL12 23170
Co-fractionation Homo sapiens
136 AREL1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
137 Rnf4  
Co-crystal Structure Rattus norvegicus
Reconstituted Complex Rattus norvegicus
Reconstituted Complex Rattus norvegicus
138 ZPR1 8882
Co-fractionation Homo sapiens
139 RNF168  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
140 TRIM2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
141 BIRC2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
142 DTL  
Reconstituted Complex Homo sapiens
143 CYP3A4  
Affinity Capture-MS Homo sapiens
144 RNF34  
Reconstituted Complex Homo sapiens
145 CDK7 1022
Reconstituted Complex Homo sapiens
146 CAND2 23066
Co-purification Homo sapiens
147 NHLRC1  
Reconstituted Complex Homo sapiens
148 AHCYL1 10768
Co-fractionation Homo sapiens
149 RNF181  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
150 MARCH1  
Reconstituted Complex Homo sapiens
151 RELA 5970
Biochemical Activity Homo sapiens
152 UBXN7 26043
Co-fractionation Homo sapiens
153 TRIM10  
Two-hybrid Homo sapiens