Gene description for ARG1
Gene name arginase 1
Gene symbol ARG1
Other names/aliases -
Species Homo sapiens
 Database cross references - ARG1
ExoCarta ExoCarta_383
Entrez Gene 383
HGNC 663
MIM 608313
UniProt P05089  
 ARG1 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for ARG1
Molecular Function
    arginase activity GO:0004053 EXP
    manganese ion binding GO:0030145 IEA
Biological Process
    collagen biosynthetic process GO:0032964 IEA
    small molecule metabolic process GO:0044281 TAS
    cellular nitrogen compound metabolic process GO:0034641 TAS
    response to amino acid GO:0043200 IEA
    cellular response to hydrogen peroxide GO:0070301 IEA
    positive regulation of endothelial cell proliferation GO:0001938 IEA
    regulation of L-arginine import GO:0010963 IEA
    protein homotrimerization GO:0070207 IEA
    cellular response to glucagon stimulus GO:0071377 IEA
    cellular response to dexamethasone stimulus GO:0071549 IEA
    lung development GO:0030324 IEA
    response to selenium ion GO:0010269 IEA
    arginine catabolic process GO:0006527 TAS
    maternal process involved in female pregnancy GO:0060135 IEA
    response to vitamin A GO:0033189 IEA
    cellular response to interleukin-4 GO:0071353 IEA
    cellular response to lipopolysaccharide GO:0071222 IEA
    response to vitamin E GO:0033197 IEA
    response to herbicide GO:0009635 IEA
    response to cadmium ion GO:0046686 IEA
    mammary gland involution GO:0060056 IEA
    response to zinc ion GO:0010043 IEA
    response to drug GO:0042493 IEA
    response to axon injury GO:0048678 IEA
    response to amine GO:0014075 IEA
    response to methylmercury GO:0051597 IEA
    response to manganese ion GO:0010042 IEA
    urea cycle GO:0000050 TAS
    liver development GO:0001889 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 TAS
    neuronal cell body GO:0043025 IEA
    cytoplasm GO:0005737 TAS
    neuron projection GO:0043005 IEA
    nucleus GO:0005634 IDA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified ARG1 in exosomes
1
Experiment ID 231
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ARG1 is involved
PathwayEvidenceSource
Urea cycle TAS Reactome





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