Gene description for FHOD1
Gene name formin homology 2 domain containing 1
Gene symbol FHOD1
Other names/aliases FHOS
Species Homo sapiens
 Database cross references - FHOD1
ExoCarta ExoCarta_29109
Entrez Gene 29109
HGNC 17905
MIM 606881
UniProt Q9Y613  
 FHOD1 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for FHOD1
Molecular Function
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
    actin binding GO:0003779 IEA
Biological Process
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    positive regulation of stress fiber assembly GO:0051496 IDA
Subcellular Localization
    membrane GO:0016020 IDA
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    stress fiber GO:0001725 IDA
    bleb GO:0032059 IEA
 Experiment description of studies that identified FHOD1 in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FHOD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF5  
Two-hybrid Homo sapiens
2 PFN2 5217
Two-hybrid Homo sapiens
3 ACTG1 71
Affinity Capture-Western Homo sapiens
4 RAC1 5879
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 LNPEP 4012
Two-hybrid Homo sapiens
6 ZMYND8 23613
Two-hybrid Homo sapiens
7 FHOD1 29109
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
8 EXOSC8  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FHOD1 is involved
No pathways found





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