Gene description for NIF3L1
Gene name NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
Gene symbol NIF3L1
Other names/aliases ALS2CR1
CALS-7
MDS015
Species Homo sapiens
 Database cross references - NIF3L1
ExoCarta ExoCarta_60491
Entrez Gene 60491
HGNC 13390
MIM 605778
UniProt Q9GZT8  
 NIF3L1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for NIF3L1
Molecular Function
    transcription factor binding GO:0008134 IPI
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    negative regulation of nucleic acid-templated transcription GO:1903507 ISS
    neuron differentiation GO:0030182 ISS
    positive regulation of transcription, DNA-templated GO:0045893 IDA
Subcellular Localization
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IBA
 Experiment description of studies that identified NIF3L1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NIF3L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MGC2749  
Two-hybrid Homo sapiens
2 GNMT  
Two-hybrid Homo sapiens
3 NUDT21 11051
Two-hybrid Homo sapiens
4 DHPS  
Two-hybrid Homo sapiens
5 TIFA  
Two-hybrid Homo sapiens
6 COPS2 9318
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
7 NIF3L1 60491
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 FLJ10094  
Two-hybrid Homo sapiens
9 DMRTB1  
Two-hybrid Homo sapiens
10 MAGEA11  
Two-hybrid Homo sapiens
11 TRIP13 9319
Two-hybrid Homo sapiens
12 TSC22D4  
Two-hybrid Homo sapiens
13 NOL3  
Two-hybrid Homo sapiens
14 MAPRE2 10982
Two-hybrid Homo sapiens
15 TRAF2  
Two-hybrid Homo sapiens
16 THOC7 80145
Two-hybrid Homo sapiens
17 SNF8 11267
Two-hybrid Homo sapiens
18 Wbscr14  
Affinity Capture-Western Mus musculus
19 PCBD1 5092
Two-hybrid Homo sapiens
20 KRT15 3866
Two-hybrid Homo sapiens
21 TRIM21 6737
Two-hybrid Homo sapiens
22 DCTD  
Two-hybrid Homo sapiens
23 RABAC1  
Two-hybrid Homo sapiens
24 BEND7 222389
Two-hybrid Homo sapiens
25 DIPA  
Two-hybrid Homo sapiens
26 YWHAQ 10971
Affinity Capture-Western Homo sapiens
27 CUTC  
Two-hybrid Homo sapiens
28 S100A1  
Two-hybrid Homo sapiens
29 RPIA 22934
Two-hybrid Homo sapiens
30 VIM 7431
Two-hybrid Homo sapiens
31 KCTD17  
Two-hybrid Homo sapiens
32 PRTFDC1  
Two-hybrid Homo sapiens
33 DCTPP1 79077
Two-hybrid Homo sapiens
34 ZBED1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which NIF3L1 is involved
No pathways found





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