Gene description for SETD1A
Gene name SET domain containing 1A
Gene symbol SETD1A
Other names/aliases KMT2F
Set1
Set1A
Species Homo sapiens
 Database cross references - SETD1A
ExoCarta ExoCarta_9739
Vesiclepedia VP_9739
Entrez Gene 9739
HGNC 29010
MIM 611052
UniProt O15047  
 SETD1A identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SETD1A
Molecular Function
    RNA binding GO:0003723 IDA
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IPI
    histone H3K4 methyltransferase activity GO:0042800 IBA
    histone H3K4 methyltransferase activity GO:0042800 IDA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    histone H3K4 monomethyltransferase activity GO:0140945 IEA
    histone H3K4 trimethyltransferase activity GO:0140999 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    DNA damage response GO:0006974 IEA
    brain development GO:0007420 IMP
    methylation GO:0032259 IEA
    regulation of hematopoietic stem cell differentiation GO:1902036 IDA
    regulation of chromatin organization GO:1902275 IDA
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IMP
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    nuclear speck GO:0016607 IDA
    histone methyltransferase complex GO:0035097 IDA
    Set1C/COMPASS complex GO:0048188 IBA
    Set1C/COMPASS complex GO:0048188 IDA
    Set1C/COMPASS complex GO:0048188 IPI
    Set1C/COMPASS complex GO:0048188 TAS
 Experiment description of studies that identified SETD1A in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SETD1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCRS1  
Affinity Capture-MS Homo sapiens
2 NCOA6  
Co-fractionation Homo sapiens
3 KMT2C 58508
Affinity Capture-MS Homo sapiens
4 CDC42BPB 9578
Affinity Capture-MS Homo sapiens
5 ELF1 1997
Proximity Label-MS Homo sapiens
6 FEV  
Proximity Label-MS Homo sapiens
7 TPD52L2 7165
Affinity Capture-MS Homo sapiens
8 NFYC 4802
Proximity Label-MS Homo sapiens
9 EPB41L5 57669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ZZZ3  
Affinity Capture-MS Homo sapiens
11 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
12 KPNA2 3838
Affinity Capture-MS Homo sapiens
13 RSBN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 KANSL3  
Affinity Capture-MS Homo sapiens
15 ATN1  
Affinity Capture-MS Homo sapiens
16 ELF4 2000
Proximity Label-MS Homo sapiens
17 HSPA5 3309
Co-fractionation Homo sapiens
18 CTDSP2 10106
Affinity Capture-MS Homo sapiens
19 TRIM28 10155
Affinity Capture-MS Homo sapiens
20 SULF2 55959
Affinity Capture-MS Homo sapiens
21 INSRR 3645
Affinity Capture-MS Homo sapiens
22 KLF8  
Proximity Label-MS Homo sapiens
23 NFKBIL1  
Affinity Capture-MS Homo sapiens
24 SMARCA1 6594
Affinity Capture-Western Homo sapiens
25 TRA2B 6434
Affinity Capture-MS Homo sapiens
26 KMT2D 8085
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PRPS1 5631
Affinity Capture-MS Homo sapiens
28 SYT2  
Affinity Capture-MS Homo sapiens
29 HCFC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 ZXDB  
Affinity Capture-MS Homo sapiens
31 GRWD1 83743
Affinity Capture-Western Homo sapiens
32 PAXIP1  
Affinity Capture-MS Homo sapiens
33 ANAPC7 51434
Affinity Capture-MS Homo sapiens
34 ASH2L 9070
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 POLR2C 5432
Proximity Label-MS Homo sapiens
36 Wdr82  
Affinity Capture-MS Mus musculus
37 WDR5 11091
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
38 KAT8  
Affinity Capture-MS Homo sapiens
39 MAD2L1 4085
Affinity Capture-MS Homo sapiens
40 MTA2 9219
Affinity Capture-MS Homo sapiens
41 CTCF  
Affinity Capture-MS Homo sapiens
42 PRPS2 5634
Affinity Capture-MS Homo sapiens
43 PES1 23481
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 KDM6A  
Affinity Capture-MS Homo sapiens
45 KANSL1  
Affinity Capture-MS Homo sapiens
46 EPB41L3 23136
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CXXC1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 PCNT  
Affinity Capture-MS Homo sapiens
49 BOD1L1 259282
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 PHF20L1  
Affinity Capture-MS Homo sapiens
51 LANCL1 10314
Affinity Capture-MS Homo sapiens
52 FHL3 2275
Affinity Capture-MS Homo sapiens
53 ZNF207 7756
Affinity Capture-MS Homo sapiens
54 NFIX 4784
Proximity Label-MS Homo sapiens
55 CBX3 11335
Affinity Capture-MS Homo sapiens
56 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
57 ARRDC2  
Affinity Capture-MS Homo sapiens
58 OGT 8473
Affinity Capture-MS Homo sapiens
59 RAD18  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
60 PRMT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 RPL37A 6168
Affinity Capture-MS Homo sapiens
62 ZNF784  
Affinity Capture-MS Homo sapiens
63 FGFRL1 53834
Affinity Capture-MS Homo sapiens
64 TBC1D10B 26000
Affinity Capture-MS Homo sapiens
65 KLF12  
Proximity Label-MS Homo sapiens
66 CCBL2 56267
Co-fractionation Homo sapiens
67 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
68 CT45A5  
Affinity Capture-MS Homo sapiens
69 WDR82 80335
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
70 TRIM21 6737
Affinity Capture-MS Homo sapiens
71 YEATS2  
Affinity Capture-MS Homo sapiens
72 EPB41L1 2036
Affinity Capture-MS Homo sapiens
73 HIST1H3A 8350
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
74 KMT2A  
Affinity Capture-MS Homo sapiens
75 ARHGAP10 79658
Affinity Capture-MS Homo sapiens
76 TP53BP1 7158
Affinity Capture-MS Homo sapiens
77 HIST2H3C 126961
Biochemical Activity Homo sapiens
78 BAG2 9532
Affinity Capture-MS Homo sapiens
79 ELK3  
Proximity Label-MS Homo sapiens
80 AHNAK 79026
Affinity Capture-MS Homo sapiens
81 HCFC1 3054
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
82 CSRP2BP  
Affinity Capture-MS Homo sapiens
83 PYCR1 5831
Affinity Capture-MS Homo sapiens
84 YY1 7528
Proximity Label-MS Homo sapiens
85 KANSL2  
Affinity Capture-MS Homo sapiens
86 POLR2A 5430
Affinity Capture-Western Homo sapiens
87 RBBP4 5928
Affinity Capture-MS Homo sapiens
88 PHF20  
Affinity Capture-MS Homo sapiens
89 HNF4A  
Proximity Label-MS Homo sapiens
90 MYC  
Proximity Label-MS Homo sapiens
91 RPA3 6119
Proximity Label-MS Homo sapiens
92 PHF5A 84844
Affinity Capture-MS Homo sapiens
93 CHD8 57680
Affinity Capture-MS Homo sapiens
94 PARP1 142
Affinity Capture-MS Homo sapiens
95 KRAS 3845
Negative Genetic Homo sapiens
96 Cxxc1  
Affinity Capture-MS Mus musculus
97 RBBP5 5929
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
98 MYB  
Proximity Label-MS Homo sapiens
99 FHL2 2274
Affinity Capture-MS Homo sapiens
100 RERE 473
Affinity Capture-MS Homo sapiens
101 PRKDC 5591
Affinity Capture-MS Homo sapiens
102 Smchd1  
Affinity Capture-MS Mus musculus
103 TAF6 6878
Co-fractionation Homo sapiens
104 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
105 FGF11  
Affinity Capture-MS Homo sapiens
106 WDR82P1  
Affinity Capture-Western Homo sapiens
107 SIRT6  
Affinity Capture-MS Homo sapiens
108 EPB41L4B 54566
Affinity Capture-MS Homo sapiens
109 TP53 7157
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
110 MDK 4192
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 RUVBL2 10856
Affinity Capture-MS Homo sapiens
112 KMT2B  
Affinity Capture-MS Homo sapiens
113 UVSSA  
Affinity Capture-MS Homo sapiens
114 HDAC6 10013
Affinity Capture-MS Homo sapiens
115 MEN1 4221
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 DPY30 84661
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 PLCD3 113026
Affinity Capture-MS Homo sapiens
118 CHST5  
Affinity Capture-MS Homo sapiens
119 PNISR  
Co-fractionation Homo sapiens
120 CREBBP  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
121 CHD4 1108
Affinity Capture-MS Homo sapiens
122 EPB41L2 2037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 BUB3 9184
Affinity Capture-MS Homo sapiens
124 MKI67  
Affinity Capture-MS Homo sapiens
125 SETD1B 23067
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
126 NUP50 10762
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 EDA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 NEK2  
Affinity Capture-MS Homo sapiens
129 MBIP  
Affinity Capture-MS Homo sapiens
130 ZNF608  
Affinity Capture-MS Homo sapiens
131 HSPA8 3312
Co-fractionation Homo sapiens
132 DAXX  
Affinity Capture-MS Homo sapiens
133 ELF2  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 CAMK2D 817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 USF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
136 HSPA1B 3304
Affinity Capture-MS Homo sapiens
137 LBP 3929
Two-hybrid Homo sapiens
138 EP300 2033
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
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