Gene description for RLIM
Gene name ring finger protein, LIM domain interacting
Gene symbol RLIM
Other names/aliases NY-REN-43
RNF12
Species Homo sapiens
 Database cross references - RLIM
ExoCarta ExoCarta_51132
Vesiclepedia VP_51132
Entrez Gene 51132
HGNC 13429
MIM 300379
UniProt Q9NVW2  
 RLIM identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for RLIM
Molecular Function
    transcription corepressor activity GO:0003714 NAS
    ubiquitin-protein transferase activity GO:0004842 ISS
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 ISS
    protein ubiquitination GO:0016567 IBA
    protein ubiquitination GO:0016567 IEA
    protein ubiquitination GO:0016567 ISS
    negative regulation of DNA-templated transcription GO:0045892 NAS
    random inactivation of X chromosome GO:0060816 IBA
    random inactivation of X chromosome GO:0060816 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    transcription repressor complex GO:0017053 NAS
 Experiment description of studies that identified RLIM in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for RLIM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-MS Homo sapiens
2 CITED1 4435
Affinity Capture-MS Homo sapiens
3 HIST1H4K 8362
Affinity Capture-MS Homo sapiens
4 PPP1CB 5500
Affinity Capture-MS Homo sapiens
5 HDAC2 3066
Affinity Capture-Western Homo sapiens
6 KRT1 3848
Affinity Capture-MS Homo sapiens
7 NFIB  
Affinity Capture-MS Homo sapiens
8 ARPC2 10109
Affinity Capture-MS Homo sapiens
9 KRT6A 3853
Affinity Capture-MS Homo sapiens
10 ARPC4 10093
Affinity Capture-MS Homo sapiens
11 DNAJB2 3300
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ACTC1 70
Affinity Capture-MS Homo sapiens
13 SLC25A1 6576
Affinity Capture-MS Homo sapiens
14 AIF1L 83543
Affinity Capture-MS Homo sapiens
15 PCBP3 54039
Affinity Capture-MS Homo sapiens
16 RIPK3 11035
Affinity Capture-MS Homo sapiens
17 TRMU  
Affinity Capture-MS Homo sapiens
18 MPP5 64398
Affinity Capture-MS Homo sapiens
19 ACTR3 10096
Affinity Capture-MS Homo sapiens
20 AP2A1 160
Affinity Capture-MS Homo sapiens
21 FAM174A 345757
Affinity Capture-MS Homo sapiens
22 TRIOBP 11078
Affinity Capture-MS Homo sapiens
23 FBL 2091
Affinity Capture-MS Homo sapiens
24 RPS9 6203
Affinity Capture-MS Homo sapiens
25 KRT78 196374
Affinity Capture-MS Homo sapiens
26 KPRP 448834
Affinity Capture-MS Homo sapiens
27 PZP 5858
Affinity Capture-MS Homo sapiens
28 DHX9 1660
Affinity Capture-MS Homo sapiens
29 HIST1H3H 8357
Affinity Capture-MS Homo sapiens
30 RPL19 6143
Affinity Capture-MS Homo sapiens
31 RBM14 10432
Affinity Capture-MS Homo sapiens
32 MYL6 4637
Affinity Capture-MS Homo sapiens
33 BAG6 7917
Affinity Capture-MS Homo sapiens
34 UNK  
Affinity Capture-RNA Homo sapiens
35 TOLLIP 54472
Affinity Capture-MS Homo sapiens
36 SULT1C4  
Affinity Capture-MS Homo sapiens
37 CAPZA1 829
Affinity Capture-MS Homo sapiens
38 PGAM5 192111
Affinity Capture-MS Homo sapiens
39 HIST1H3C 8352
Affinity Capture-MS Homo sapiens
40 HIST1H2AG 8969
Affinity Capture-MS Homo sapiens
41 TUFM 7284
Affinity Capture-MS Homo sapiens
42 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
43 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
44 RPL18A 6142
Affinity Capture-MS Homo sapiens
45 EFHD1  
Affinity Capture-MS Homo sapiens
46 MYH9 4627
Affinity Capture-MS Homo sapiens
47 ACTN4 81
Affinity Capture-MS Homo sapiens
48 ARHGAP11A  
Affinity Capture-MS Homo sapiens
49 F12  
Affinity Capture-MS Homo sapiens
50 LRCH3 84859
Affinity Capture-MS Homo sapiens
51 BCLAF1 9774
Affinity Capture-MS Homo sapiens
52 HSPA5 3309
Affinity Capture-MS Homo sapiens
53 BRF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
54 HIST1H3F 8968
Affinity Capture-MS Homo sapiens
55 POTEI 653269
Affinity Capture-MS Homo sapiens
56 MYH14 79784
Affinity Capture-MS Homo sapiens
57 UBC 7316
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
58 ACTBL2 345651
Affinity Capture-MS Homo sapiens
59 MYO1C 4641
Affinity Capture-MS Homo sapiens
60 HIST1H4B 8366
Affinity Capture-MS Homo sapiens
61 PCBP4 57060
Affinity Capture-MS Homo sapiens
62 GNAS 2778
Affinity Capture-MS Homo sapiens
63 SNX17 9784
Two-hybrid Homo sapiens
64 AP2A2 161
Affinity Capture-MS Homo sapiens
65 HSPA1A 3303
Affinity Capture-MS Homo sapiens
66 STMN1 3925
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
67 HIST1H4I 8294
Affinity Capture-MS Homo sapiens
68 AKT1 207
Affinity Capture-Western Homo sapiens
69 MYH10 4628
Affinity Capture-MS Homo sapiens
70 TPM4 7171
Affinity Capture-MS Homo sapiens
71 RPS16 6217
Affinity Capture-MS Homo sapiens
72 ARPC3 10094
Affinity Capture-MS Homo sapiens
73 RPS27A 6233
Affinity Capture-MS Homo sapiens
74 NAAA  
Affinity Capture-MS Homo sapiens
75 TIA1 7072
Affinity Capture-MS Homo sapiens
76 LNX2  
Two-hybrid Homo sapiens
77 ASIC4  
Affinity Capture-MS Homo sapiens
78 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
79 TRMT112 51504
Affinity Capture-MS Homo sapiens
80 RPS15A 6210
Affinity Capture-MS Homo sapiens
81 KRT24 192666
Affinity Capture-MS Homo sapiens
82 HIST1H4L 8368
Affinity Capture-MS Homo sapiens
83 GAPDH 2597
Affinity Capture-MS Homo sapiens
84 APBA2 321
Affinity Capture-MS Homo sapiens
85 HIST1H4J 8363
Affinity Capture-MS Homo sapiens
86 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
87 CST11  
Affinity Capture-MS Homo sapiens
88 TXNIP 10628
Affinity Capture-MS Homo sapiens
89 IGLV1-51  
Affinity Capture-MS Homo sapiens
90 NFIC 4782
Affinity Capture-MS Homo sapiens
91 IGKV2-40  
Affinity Capture-MS Homo sapiens
92 SMURF2 64750
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
93 HSPA1B 3304
Affinity Capture-MS Homo sapiens
94 GNAI3 2773
Affinity Capture-MS Homo sapiens
95 PSMD3 5709
Affinity Capture-MS Homo sapiens
96 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
97 KRT77 374454
Affinity Capture-MS Homo sapiens
98 LDHA 3939
Affinity Capture-MS Homo sapiens
99 LYZ 4069
Affinity Capture-MS Homo sapiens
100 UBE2K 3093
Reconstituted Complex Homo sapiens
101 NFE2L1  
Affinity Capture-MS Homo sapiens
102 ALB 213
Affinity Capture-MS Homo sapiens
103 RFXANK  
Affinity Capture-MS Homo sapiens
104 ARF3 377
Affinity Capture-MS Homo sapiens
105 PKD1L2  
Affinity Capture-MS Homo sapiens
106 RPL14 9045
Affinity Capture-MS Homo sapiens
107 ASXL1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
108 RPS3 6188
Affinity Capture-MS Homo sapiens
109 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
110 RPS18 6222
Affinity Capture-MS Homo sapiens
111 MDM2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
112 IGKV3D-7  
Affinity Capture-MS Homo sapiens
113 C3 718
Affinity Capture-MS Homo sapiens
114 CIB3  
Affinity Capture-MS Homo sapiens
115 NPM1 4869
Affinity Capture-MS Homo sapiens
116 HIST4H4 121504
Affinity Capture-MS Homo sapiens
117 KRT16 3868
Affinity Capture-MS Homo sapiens
118 NPAS1  
Affinity Capture-MS Homo sapiens
119 TWF1 5756
Affinity Capture-MS Homo sapiens
120 AMOT  
Affinity Capture-MS Homo sapiens
121 PRNP 5621
Affinity Capture-MS Homo sapiens
122 GTF2I 2969
Affinity Capture-MS Homo sapiens
123 CALM2 805
Affinity Capture-MS Homo sapiens
124 DSG1 1828
Affinity Capture-MS Homo sapiens
125 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
126 DDX21 9188
Affinity Capture-MS Homo sapiens
127 RPL4 6124
Affinity Capture-MS Homo sapiens
128 HIST1H4E 8367
Affinity Capture-MS Homo sapiens
129 RAI14 26064
Affinity Capture-MS Homo sapiens
130 LYN 4067
Affinity Capture-MS Homo sapiens
131 NOL11  
Affinity Capture-MS Homo sapiens
132 EFHD2 79180
Affinity Capture-MS Homo sapiens
133 SNRPB 6628
Affinity Capture-MS Homo sapiens
134 HIST1H3J 8356
Affinity Capture-MS Homo sapiens
135 NFIA 4774
Affinity Capture-MS Homo sapiens
136 LHX3  
Reconstituted Complex Homo sapiens
137 KRT14 3861
Affinity Capture-MS Homo sapiens
138 RPLP0 6175
Affinity Capture-MS Homo sapiens
139 SS18L1  
Two-hybrid Homo sapiens
140 HBA1 3039
Affinity Capture-MS Homo sapiens
141 UBXN6 80700
Affinity Capture-MS Homo sapiens
142 RSL1D1 26156
Affinity Capture-MS Homo sapiens
143 F2 2147
Affinity Capture-MS Homo sapiens
144 TUBB 203068
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 RPS2 6187
Affinity Capture-MS Homo sapiens
146 ARPC1B 10095
Affinity Capture-MS Homo sapiens
147 KIAA1211L 343990
Affinity Capture-MS Homo sapiens
148 TUBB4B 10383
Affinity Capture-MS Homo sapiens
149 UBE2E1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
150 NUP43 348995
Affinity Capture-MS Homo sapiens
151 FUS 2521
Affinity Capture-MS Homo sapiens
152 SERINC5 256987
Affinity Capture-MS Homo sapiens
153 AXIN2 8313
Affinity Capture-Western Homo sapiens
154 TFG 10342
Affinity Capture-MS Homo sapiens
155 C4A 720
Affinity Capture-MS Homo sapiens
156 HIST1H3B 8358
Affinity Capture-MS Homo sapiens
157 MYC  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
158 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
159 TMOD3 29766
Affinity Capture-MS Homo sapiens
160 EEF1A2 1917
Affinity Capture-MS Homo sapiens
161 HIST1H4F 8361
Affinity Capture-MS Homo sapiens
162 CDK20  
Affinity Capture-MS Homo sapiens
163 DDB1 1642
Affinity Capture-MS Homo sapiens
164 RPS11 6205
Affinity Capture-MS Homo sapiens
165 ARGLU1  
Affinity Capture-MS Homo sapiens
166 MPRIP 23164
Affinity Capture-MS Homo sapiens
167 FTSJ3 117246
Affinity Capture-MS Homo sapiens
168 PHGDH 26227
Affinity Capture-MS Homo sapiens
169 DSP 1832
Affinity Capture-MS Homo sapiens
170 HIST2H4A 8370
Affinity Capture-MS Homo sapiens
171 ZRANB1 54764
Affinity Capture-MS Homo sapiens
172 RPL13 6137
Affinity Capture-MS Homo sapiens
173 SLC25A3 5250
Affinity Capture-MS Homo sapiens
174 C4B 721
Affinity Capture-MS Homo sapiens
175 GRN 2896
Affinity Capture-MS Homo sapiens
176 HNRNPH2 3188
Affinity Capture-MS Homo sapiens
177 PARP1 142
Affinity Capture-MS Homo sapiens
178 SMAD7  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
179 RPL6 6128
Affinity Capture-MS Homo sapiens
180 COMMD5 28991
Affinity Capture-MS Homo sapiens
181 EZR 7430
Affinity Capture-MS Homo sapiens
182 CAPZA2 830
Affinity Capture-MS Homo sapiens
183 RPS27 6232
Affinity Capture-MS Homo sapiens
184 SMPDL3B 27293
Affinity Capture-MS Homo sapiens
185 RPS5 6193
Affinity Capture-MS Homo sapiens
186 DCD 117159
Affinity Capture-MS Homo sapiens
187 RPL7A 6130
Affinity Capture-MS Homo sapiens
188 PRDX1 5052
Affinity Capture-MS Homo sapiens
189 TNNC2  
Affinity Capture-MS Homo sapiens
190 MYL12B 103910
Affinity Capture-MS Homo sapiens
191 HBZ  
Affinity Capture-MS Homo sapiens
192 TCP1 6950
Affinity Capture-MS Homo sapiens
193 FLG2 388698
Affinity Capture-MS Homo sapiens
194 HNRNPC 3183
Affinity Capture-MS Homo sapiens
195 SENP3 26168
Affinity Capture-MS Homo sapiens
196 NOP58 51602
Affinity Capture-MS Homo sapiens
197 TMOD2 29767
Affinity Capture-MS Homo sapiens
198 EFR3A 23167
Affinity Capture-MS Homo sapiens
199 HIST1H2BJ 8970
Affinity Capture-MS Homo sapiens
200 CAPZB 832
Affinity Capture-MS Homo sapiens
201 GNG12 55970
Affinity Capture-MS Homo sapiens
202 RPL10A 4736
Affinity Capture-MS Homo sapiens
203 TNRC6A 27327
Affinity Capture-MS Homo sapiens
204 UBE2E2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
205 HIST1H3G 8355
Affinity Capture-MS Homo sapiens
206 HES6  
Affinity Capture-MS Homo sapiens
207 EWSR1 2130
Affinity Capture-MS Homo sapiens
208 KRT5 3852
Affinity Capture-MS Homo sapiens
209 ATG7 10533
Affinity Capture-MS Homo sapiens
210 STAT6 6778
Two-hybrid Homo sapiens
211 CFLAR  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
212 PDLIM1 9124
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
213 HSPA8 3312
Affinity Capture-MS Homo sapiens
214 BRIX1 55299
Affinity Capture-MS Homo sapiens
215 RPL27 6155
Affinity Capture-MS Homo sapiens
216 ATAD3B 83858
Affinity Capture-MS Homo sapiens
217 IRS4 8471
Affinity Capture-MS Homo sapiens
218 ATP5A1 498
Affinity Capture-MS Homo sapiens
219 TRMT61A 115708
Affinity Capture-MS Homo sapiens
220 ANTXR1 84168
Affinity Capture-MS Homo sapiens
221 CENPV 201161
Affinity Capture-MS Homo sapiens
222 CHCHD3 54927
Affinity Capture-MS Homo sapiens
223 TUBA1A 7846
Affinity Capture-MS Homo sapiens
224 ACACA 31
Negative Genetic Homo sapiens
225 TUBA1B 10376
Affinity Capture-MS Homo sapiens
226 IGHG4 3503
Affinity Capture-MS Homo sapiens
227 PABPC1 26986
Affinity Capture-MS Homo sapiens
228 KRT17 3872
Affinity Capture-MS Homo sapiens
229 ACTB 60
Affinity Capture-MS Homo sapiens
230 UBE2D3 7323
Two-hybrid Homo sapiens
231 GNAI2 2771
Affinity Capture-MS Homo sapiens
232 HIST1H2BK 85236
Affinity Capture-MS Homo sapiens
233 TMEM33 55161
Affinity Capture-MS Homo sapiens
234 ARPC1A 10552
Affinity Capture-MS Homo sapiens
235 DBN1 1627
Affinity Capture-MS Homo sapiens
236 NMNAT2  
Affinity Capture-MS Homo sapiens
237 HIST1H2AI 8329
Affinity Capture-MS Homo sapiens
238 TRIM21 6737
Affinity Capture-MS Homo sapiens
239 HIST1H4H 8365
Affinity Capture-MS Homo sapiens
240 HIST1H4D 8360
Affinity Capture-MS Homo sapiens
241 SMARCA5 8467
Affinity Capture-MS Homo sapiens
242 KRT9 3857
Affinity Capture-MS Homo sapiens
243 EEF2 1938
Affinity Capture-MS Homo sapiens
244 HRNR 388697
Affinity Capture-MS Homo sapiens
245 DIRAS2 54769
Affinity Capture-MS Homo sapiens
246 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
247 HIST2H4B 554313
Affinity Capture-MS Homo sapiens
248 RPL11 6135
Affinity Capture-MS Homo sapiens
249 DHX30 22907
Affinity Capture-MS Homo sapiens
250 HNRNPUL1 11100
Affinity Capture-MS Homo sapiens
251 MYO1D 4642
Affinity Capture-MS Homo sapiens
252 RPS14 6208
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
253 DNAJC10 54431
Affinity Capture-MS Homo sapiens
254 FLII 2314
Affinity Capture-MS Homo sapiens
255 HIST1H3I 8354
Affinity Capture-MS Homo sapiens
256 MSN 4478
Affinity Capture-MS Homo sapiens
257 HSPA9 3313
Affinity Capture-MS Homo sapiens
258 XRCC5 7520
Affinity Capture-MS