Gene description for MMRN2
Gene name multimerin 2
Gene symbol MMRN2
Other names/aliases EMILIN-3
EMILIN3
ENDOGLYX-1
Species Homo sapiens
 Database cross references - MMRN2
ExoCarta ExoCarta_79812
Vesiclepedia VP_79812
Entrez Gene 79812
HGNC 19888
MIM 608925
UniProt Q9H8L6  
 MMRN2 identified in exosomes derived from the following tissue/cell type
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for MMRN2
Molecular Function
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
    receptor ligand activity GO:0048018 IDA
Biological Process
    angiogenesis GO:0001525 IDA
    cell migration involved in sprouting angiogenesis GO:0002042 IEA
    cell adhesion GO:0007155 NAS
    signal transduction GO:0007165 IEA
    negative regulation of cell population proliferation GO:0008285 IDA
    negative regulation of cell migration GO:0030336 IDA
    negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 IBA
    negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 IDA
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IBA
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IDA
    positive regulation of defense response to bacterium GO:1900426 ISO
    negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 IDA
    positive regulation of epithelial tube formation GO:1905278 IDA
    positive regulation of morphogenesis of an epithelium GO:1905332 IDA
Subcellular Localization
    basement membrane GO:0005604 IEA
    extracellular space GO:0005615 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 IDA
    extracellular exosome GO:0070062 HDA
    multimerin complex GO:1990972 ISS
 Experiment description of studies that identified MMRN2 in exosomes
1
Experiment ID 13
MISEV standards
IEM
Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MMRN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VDR  
Two-hybrid Homo sapiens
2 TRIM21 6737
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MMRN2 is involved
No pathways found





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