Gene description for ADGRG4
Gene name adhesion G protein-coupled receptor G4
Gene symbol ADGRG4
Other names/aliases GPR112
PGR17
RP1-299I16
Species Homo sapiens
 Database cross references - ADGRG4
ExoCarta ExoCarta_139378
Vesiclepedia VP_139378
Entrez Gene 139378
HGNC 18992
UniProt Q8IZF6  
 ADGRG4 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ADGRG4
Molecular Function
    G protein-coupled receptor activity GO:0004930 IBA
Biological Process
    cell surface receptor signaling pathway GO:0007166 IEA
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    membrane GO:0016020 TAS
 Experiment description of studies that identified ADGRG4 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ADGRG4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CEP72  
Affinity Capture-MS Homo sapiens
2 TRIM21 6737
Affinity Capture-MS Homo sapiens
3 PARK2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ADGRG4 is involved
No pathways found





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