Gene description for PRKCZ
Gene name	protein kinase C, zeta
Gene symbol	PRKCZ
Other names/aliases	PKC-ZETA PKC2
Species	Homo sapiens
Database cross references - PRKCZ
ExoCarta	ExoCarta_5590
Entrez Gene	5590
HGNC	9412
MIM	176982
UniProt	Q05513
PRKCZ identified in exosomes derived from the following tissue/cell type
Urine	19056867

Gene ontology annotations for PRKCZ

Molecular Function     protein kinase C activity GO:0004697 IEA     insulin receptor substrate binding GO:0043560 IC     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IEA     phospholipase binding GO:0043274 IEA     potassium channel regulator activity GO:0015459 IEA     ATP binding GO:0005524 IEA     protein domain specific binding GO:0019904 IEA     14-3-3 protein binding GO:0071889 IEA     metal ion binding GO:0046872 IEA     protein kinase activity GO:0004672 IDA     protein serine/threonine kinase activity GO:0004674 IDA Biological Process     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     platelet activation GO:0030168 TAS     negative regulation of protein complex assembly GO:0031333 IMP     negative regulation of hydrolase activity GO:0051346 IEA     inflammatory response GO:0006954 IEA     protein heterooligomerization GO:0051291 IEA     activation of phospholipase D activity GO:0031584 IEA     establishment of cell polarity GO:0030010 ISS     peptidyl-serine phosphorylation GO:0018105 IDA     positive regulation of interleukin-13 secretion GO:2000667 ISS     protein localization to plasma membrane GO:0072659 IEA     activation of protein kinase B activity GO:0032148 IEA     protein phosphorylation GO:0006468 IDA     protein kinase C signaling GO:0070528 IEA     positive regulation of excitatory postsynaptic membrane potential GO:2000463 ISS     positive regulation of cell-matrix adhesion GO:0001954 IEA     negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 IMP     positive regulation of interleukin-10 secretion GO:2001181 ISS     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS     positive regulation of interleukin-4 production GO:0032753 ISS     signal transduction GO:0007165 TAS     negative regulation of apoptotic process GO:0043066 IEA     membrane hyperpolarization GO:0060081 IEA     positive regulation of insulin receptor signaling pathway GO:0046628 ISS     negative regulation of insulin receptor signaling pathway GO:0046627 IMP     positive regulation of T-helper 2 cell differentiation GO:0045630 ISS     positive regulation of interleukin-5 secretion GO:2000664 ISS     actin cytoskeleton reorganization GO:0031532 IEA     vesicle transport along microtubule GO:0047496 IEA     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     positive regulation of glucose import GO:0046326 IEA     insulin receptor signaling pathway GO:0008286 IEA     positive regulation of T-helper 2 cell cytokine production GO:2000553 ISS     microtubule cytoskeleton organization GO:0000226 IEA     cell migration GO:0016477 IEA     long-term memory GO:0007616 IEA     positive regulation of cell proliferation GO:0008284 IEA     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     long-term synaptic potentiation GO:0060291 ISS     neuron projection extension GO:1990138 IEA     blood coagulation GO:0007596 TAS Subcellular Localization     membrane raft GO:0045121 IEA     apical plasma membrane GO:0016324 IEA     cell leading edge GO:0031252 IEA     filamentous actin GO:0031941 IEA     cell-cell junction GO:0005911 IDA     perinuclear region of cytoplasm GO:0048471 IEA     endosome GO:0005768 IEA     plasma membrane GO:0005886 TAS     membrane GO:0016020 TAS     extracellular exosome GO:0070062 IDA     axon hillock GO:0043203 IEA     nuclear envelope GO:0005635 IEA     myelin sheath abaxonal region GO:0035748 IEA     bicellular tight junction GO:0005923 IEA     cytosol GO:0005829 TAS     nuclear matrix GO:0016363 IEA     microtubule organizing center GO:0005815 IEA     cytoplasm GO:0005737 TAS     cell junction GO:0030054 TAS     apical cortex GO:0045179 IEA