Gene ontology annotations for DMD
Experiment description of studies that identified DMD in exosomes
1
Experiment ID
489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 6
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
2
Experiment ID
490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 7
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
3
Experiment ID
491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 8
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
4
Experiment ID
492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
36408942
Organism
Rattus norvegicus
Experiment description
Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors
"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name
Proteomics
Publication year
2023
Sample
Bone marrow mesenchymal stem cells
Sample name
BMSC - Passage 9
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectometry
5
Experiment ID
207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23161513
Organism
Homo sapiens
Experiment description
Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors
"Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name
Mol Cell Proteomics
Publication year
2012
Sample
Colorectal cancer cells
Sample name
DKO-1
Isolation/purification methods
Differential centrifugation Filtration
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
6
Experiment ID
208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23161513
Organism
Homo sapiens
Experiment description
Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors
"Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name
Mol Cell Proteomics
Publication year
2012
Sample
Colorectal cancer cells
Sample name
Dks-8
Isolation/purification methods
Differential centrifugation Filtration
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
7
Experiment ID
209
MISEV standards
✘
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23161513
Organism
Homo sapiens
Experiment description
Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors
"Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name
Mol Cell Proteomics
Publication year
2012
Sample
Colorectal cancer cells
Sample name
DLD-1
Isolation/purification methods
Differential centrifugation Filtration
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
8
Experiment ID
1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘
Negative markers
✘
Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
34887515
Organism
Homo sapiens
Experiment description
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors
"Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name
Nat Cell Biol
Publication year
2021
Sample
Colorectal cancer cells
Sample name
DiFi
Isolation/purification methods
Differential centrifugation Filtration Centrifugal ultrafiltration Ultracentrifugation OptiPrep density gradient centrifugation
Flotation density
-
Molecules identified in the study
Protein miRNA
Methods used in the study
Western blotting Mass spectrometry RNA sequencing
9
Experiment ID
237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule
mRNA
Identification method
RNA Sequencing
PubMed ID
26054723
Organism
Homo sapiens
Experiment description
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors
"He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name
Carcinogenesis
Publication year
2015
Sample
Hepatocytes
Sample name
MIHA
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient
Flotation density
1.13-1.19 g/mL
Molecules identified in the study
Protein RNA
Methods used in the study
Western blotting Mass spectrometry RNA Sequencing
10
Experiment ID
834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
35333565
Organism
Homo sapiens
Experiment description
LAMP2A regulates the loading of proteins into exosomes
Authors
"Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name
Sci Adv
Publication year
2022
Sample
Retinal pigment epithelial cells
Sample name
ARPE-19
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectrometry
11
Experiment ID
835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule
Protein
Identification method
Mass spectrometry
PubMed ID
35333565
Organism
Homo sapiens
Experiment description
LAMP2A regulates the loading of proteins into exosomes
Authors
"Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name
Sci Adv
Publication year
2022
Sample
Retinal pigment epithelial cells
Sample name
ARPE-19
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Mass spectrometry
Protein-protein interactions for DMD
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
MPP6
51678
Affinity Capture-MS
Homo sapiens
2
ANLN
54443
Affinity Capture-MS
Homo sapiens
3
CDC25A
Two-hybrid
Homo sapiens
4
DISC1
27185
Two-hybrid
Homo sapiens
5
GAN
8139
Affinity Capture-MS
Homo sapiens
6
Osgep
Affinity Capture-MS
Mus musculus
7
UTRN
7402
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
8
TRMT2A
27037
Affinity Capture-MS
Homo sapiens
9
TERF2
Affinity Capture-MS
Homo sapiens
10
TNIP1
10318
Affinity Capture-MS
Homo sapiens
11
LAMTOR1
55004
Proximity Label-MS
Homo sapiens
12
NEDD4
4734
Co-fractionation
Homo sapiens
13
MCAM
4162
Proximity Label-MS
Homo sapiens
14
KCNA4
Affinity Capture-MS
Homo sapiens
15
Psmb5
19173
Affinity Capture-MS
Mus musculus
16
KIF15
56992
Affinity Capture-MS
Homo sapiens
17
KIF14
9928
Affinity Capture-MS
Homo sapiens
18
MARCKS
4082
Proximity Label-MS
Homo sapiens
19
XPO1
7514
Affinity Capture-MS
Homo sapiens
20
DAG1
1605
Co-crystal Structure
Homo sapiens
Affinity Capture-Western
Homo sapiens
21
SNTG2
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
22
LPAR6
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
23
FOXP1
27086
Protein-RNA
Homo sapiens
24
TRAF3IP1
26146
Two-hybrid
Homo sapiens
25
AHNAK
79026
Affinity Capture-Western
Homo sapiens
26
WDR54
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
27
ALB
213
Affinity Capture-MS
Homo sapiens
28
TRIM21
6737
Affinity Capture-MS
Homo sapiens
29
TNS1
7145
Affinity Capture-MS
Homo sapiens
30
TERF1
7013
Affinity Capture-MS
Homo sapiens
31
DTNA
Two-hybrid
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
32
HAUS1
Two-hybrid
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
33
RPS7
6201
Cross-Linking-MS (XL-MS)
Homo sapiens
34
TRIM41
90933
Affinity Capture-MS
Homo sapiens
35
PPIA
5478
Cross-Linking-MS (XL-MS)
Homo sapiens
36
Itgb1
24511
Reconstituted Complex
Rattus norvegicus
37
PLEKHA2
59339
Affinity Capture-MS
Homo sapiens
38
IFIT5
24138
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
39
LONRF3
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
40
LYN
4067
Proximity Label-MS
Homo sapiens
41
C15orf59
Affinity Capture-MS
Homo sapiens
42
SIRT5
23408
Affinity Capture-MS
Homo sapiens
43
TNS3
64759
Affinity Capture-MS
Homo sapiens
44
APP
351
Reconstituted Complex
Homo sapiens
45
LRRC8E
80131
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
46
PLEKHA4
57664
Affinity Capture-MS
Homo sapiens
47
SNTG1
Affinity Capture-MS
Homo sapiens
48
Slc8a1
Affinity Capture-Western
Mus musculus
49
HNF4A
Two-hybrid
Homo sapiens
50
MAP3K5
4217
Two-hybrid
Homo sapiens
51
SNTA1
6640
Protein-peptide
Homo sapiens
Affinity Capture-Western
Homo sapiens
Affinity Capture-MS
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
52
ARF6
382
Proximity Label-MS
Homo sapiens
53
ACTA1
58
Reconstituted Complex
Homo sapiens
54
MARK2
2011
Affinity Capture-Western
Homo sapiens
55
OSBPL1A
114876
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
56
ARRB1
408
Affinity Capture-MS
Homo sapiens
57
KIF23
9493
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
58
MCM2
4171
Affinity Capture-MS
Homo sapiens
59
KCNJ4
Affinity Capture-Western
Homo sapiens
60
Snta1
Reconstituted Complex
Rattus norvegicus
61
DTNB
1838
Two-hybrid
Homo sapiens
Affinity Capture-MS
Homo sapiens
Two-hybrid
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
62
TRIM63
Biochemical Activity
Homo sapiens
Affinity Capture-Western
Homo sapiens
63
HSPA1A
3303
Cross-Linking-MS (XL-MS)
Homo sapiens
64
TNS2
23371
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
65
NOS1
Co-localization
Homo sapiens
66
EPHA2
1969
Proximity Label-MS
Homo sapiens
67
SIRT2
22933
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
68
ARRDC3
57561
Affinity Capture-MS
Homo sapiens
69
PTRF
284119
Affinity Capture-Western
Homo sapiens
70
ZGPAT
Affinity Capture-MS
Homo sapiens
71
CTNNA1
1495
Co-fractionation
Homo sapiens
Affinity Capture-MS
Homo sapiens
72
SNTB2
6645
Protein-peptide
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
73
TIAM1
Affinity Capture-MS
Homo sapiens
74
Ptk2
Reconstituted Complex
Rattus norvegicus
75
Dlgap4
Affinity Capture-MS
Mus musculus
76
KCNJ12
3768
Affinity Capture-MS
Homo sapiens
77
SNTB1
6641
Reconstituted Complex
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
78
CUL4A
8451
Affinity Capture-MS
Homo sapiens
79
NFX1
Affinity Capture-MS
Homo sapiens
80
PAGE1
Affinity Capture-MS
Homo sapiens
81
NUPL1
9818
Affinity Capture-MS
Homo sapiens
82
CTNNAL1
8727
Two-hybrid
Homo sapiens
Two-hybrid
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
83
HAUS4
Affinity Capture-MS
Homo sapiens
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which DMD is involved