Gene description for ANO1
Gene name	anoctamin 1, calcium activated chloride channel
Gene symbol	ANO1
Other names/aliases	DOG1 ORAOV2 TAOS2 TMEM16A
Species	Homo sapiens
Database cross references - ANO1
ExoCarta	ExoCarta_55107
Vesiclepedia	VP_55107
Entrez Gene	55107
HGNC	21625
MIM	610108
UniProt	Q5XXA6
ANO1 identified in sEVs derived from the following tissue/cell type
Saliva	19199708

Gene ontology annotations for ANO1

Molecular Function     signaling receptor binding GO:0005102 IEA     calcium-activated cation channel activity GO:0005227 IDA     intracellularly calcium-gated chloride channel activity GO:0005229 IBA     intracellularly calcium-gated chloride channel activity GO:0005229 IDA     intracellularly calcium-gated chloride channel activity GO:0005229 IMP     intracellularly calcium-gated chloride channel activity GO:0005229 ISS     voltage-gated chloride channel activity GO:0005247 ISS     chloride channel activity GO:0005254 IDA     chloride channel activity GO:0005254 IMP     chloride channel activity GO:0005254 TAS     protein binding GO:0005515 IPI     iodide transmembrane transporter activity GO:0015111 IMP     identical protein binding GO:0042802 IPI     protein homodimerization activity GO:0042803 ISS     metal ion binding GO:0046872 IEA Biological Process     chloride transport GO:0006821 IMP     chloride transport GO:0006821 ISS     phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 ISS     iodide transport GO:0015705 IMP     monoatomic ion transmembrane transport GO:0034220 TAS     cellular response to heat GO:0034605 ISS     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IGI     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IMP     detection of temperature stimulus involved in sensory perception of pain GO:0050965 ISS     mucus secretion GO:0070254 IMP     mucus secretion GO:0070254 ISS     protein localization to membrane GO:0072657 IMP     monoatomic cation transmembrane transport GO:0098655 IEA     glial cell projection elongation GO:0106091 ISS     cellular response to peptide GO:1901653 IEA     chloride transmembrane transport GO:1902476 IBA     chloride transmembrane transport GO:1902476 IDA     chloride transmembrane transport GO:1902476 IMP Subcellular Localization     nucleoplasm GO:0005654 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 TAS     apical plasma membrane GO:0016324 IDA     chloride channel complex GO:0034707 IEA     cell projection GO:0042995 IEA     extracellular exosome GO:0070062 HDA     presynapse GO:0098793 IEA