Gene description for RAB11FIP5
Gene name RAB11 family interacting protein 5 (class I)
Gene symbol RAB11FIP5
Other names/aliases GAF1
RIP11
pp75
Species Homo sapiens
 Database cross references - RAB11FIP5
ExoCarta ExoCarta_26056
Vesiclepedia VP_26056
Entrez Gene 26056
HGNC 24845
MIM 605536
UniProt Q9BXF6  
 RAB11FIP5 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for RAB11FIP5
Molecular Function
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IEA
    gamma-tubulin binding GO:0043015 IDA
Biological Process
    insulin secretion involved in cellular response to glucose stimulus GO:0035773 ISS
    regulated exocytosis GO:0045055 IBA
    regulated exocytosis GO:0045055 ISS
    negative regulation of adiponectin secretion GO:0070164 IDA
    cellular response to acidic pH GO:0071468 IDA
    regulation of protein localization to cell surface GO:2000008 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    mitochondrion GO:0005739 IBA
    mitochondrial outer membrane GO:0005741 IDA
    early endosome GO:0005769 IBA
    early endosome GO:0005769 ISS
    Golgi apparatus GO:0005794 ISS
    secretory granule GO:0030141 IBA
    secretory granule GO:0030141 ISS
    transport vesicle membrane GO:0030658 IEA
    early endosome membrane GO:0031901 IEA
    centriolar satellite GO:0034451 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    phagocytic vesicle GO:0045335 IBA
    recycling endosome GO:0055037 IBA
    recycling endosome GO:0055037 ISS
    recycling endosome membrane GO:0055038 IEA
 Experiment description of studies that identified RAB11FIP5 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for RAB11FIP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MPST 4357
Co-fractionation Homo sapiens
2 GLRX5 51218
Co-fractionation Homo sapiens
3 C1orf198 84886
Co-fractionation Homo sapiens
4 SELM 140606
Co-fractionation Homo sapiens
5 OCLN 100506658
Proximity Label-MS Homo sapiens
6 MARCKS 4082
Proximity Label-MS Homo sapiens
7 LAMP3  
Proximity Label-MS Homo sapiens
8 GJA1 2697
Proximity Label-MS Homo sapiens
9 ATE1 11101
Affinity Capture-MS Homo sapiens
10 ARHGAP26 23092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 LACTB2 51110
Co-fractionation Homo sapiens
12 LAMP2 3920
Proximity Label-MS Homo sapiens
13 NENF 29937
Co-fractionation Homo sapiens
14 TXNDC12 51060
Co-fractionation Homo sapiens
15 PARK7 11315
Co-fractionation Homo sapiens
16 INA 9118
Co-fractionation Homo sapiens
17 PGK1 5230
Co-fractionation Homo sapiens
18 YWHAZ 7534
Affinity Capture-MS Homo sapiens
19 JMJD8  
Co-fractionation Homo sapiens
20 RAB3B 5865
Proximity Label-MS Homo sapiens
21 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 NUP93 9688
Co-fractionation Homo sapiens
23 FXN  
Co-fractionation Homo sapiens
24 ENSA 2029
Co-fractionation Homo sapiens
25 TULP3 7289
Affinity Capture-MS Homo sapiens
26 SRI 6717
Co-fractionation Homo sapiens
27 RAB9A 9367
Proximity Label-MS Homo sapiens
28 SORT1 6272
Affinity Capture-MS Homo sapiens
29 RAB35 11021
Proximity Label-MS Homo sapiens
30 RBM42  
Affinity Capture-MS Homo sapiens
31 PSAP 5660
Co-fractionation Homo sapiens
32 EBAG9 9166
Proximity Label-MS Homo sapiens
33 LAMTOR1 55004
Proximity Label-MS Homo sapiens
34 PSME3 10197
Affinity Capture-MS Homo sapiens
35 Arrb2  
Affinity Capture-MS Mus musculus
36 RAB5A 5868
Proximity Label-MS Homo sapiens
37 PCNP 57092
Co-fractionation Homo sapiens
38 PRDX5 25824
Co-fractionation Homo sapiens
39 MCC 4163
Affinity Capture-MS Homo sapiens
40 NCKIPSD 51517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 RAB14 51552
Far Western Homo sapiens
Two-hybrid Homo sapiens
42 CXADR 1525
Proximity Label-MS Homo sapiens
43 LYN 4067
Proximity Label-MS Homo sapiens
44 MCAM 4162
Proximity Label-MS Homo sapiens
45 RAB4A 5867
Proximity Label-MS Homo sapiens
46 DNAJC5 80331
Proximity Label-MS Homo sapiens
47 RAB11FIP4  
Two-hybrid Homo sapiens
48 YWHAE 7531
Affinity Capture-MS Homo sapiens
49 TRIM21 6737
Biochemical Activity Homo sapiens
50 SCAMP2 10066
Affinity Capture-MS Homo sapiens
51 CBX5 23468
Co-fractionation Homo sapiens
52 SMAD3 4088
Affinity Capture-MS Homo sapiens
53 ANXA4 307
Co-fractionation Homo sapiens
54 NOS2  
Co-fractionation Homo sapiens
55 STX6 10228
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
56 ARRDC3 57561
Affinity Capture-MS Homo sapiens
57 ENO1 2023
Co-fractionation Homo sapiens
58 CTSB 1508
Co-fractionation Homo sapiens
59 RAB11FIP5 26056
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 HGFAC 3083
Co-fractionation Homo sapiens
61 ZYG11B  
Affinity Capture-MS Homo sapiens
62 DDAH2 23564
Co-fractionation Homo sapiens
63 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
64 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
65 NAPG 8774
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
66 STXBP2 6813
Co-fractionation Homo sapiens
67 XPO1 7514
Affinity Capture-MS Homo sapiens
68 HN1 51155
Co-fractionation Homo sapiens
69 RNF43  
Proximity Label-MS Homo sapiens
70 RAB25 57111
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
71 PTPRH 5794
Proximity Label-MS Homo sapiens
72 NR3C1 2908
Proximity Label-MS Homo sapiens
73 PHPT1 29085
Co-fractionation Homo sapiens
74 ARF6 382
Reconstituted Complex Homo sapiens
75 ECHS1 1892
Co-fractionation Homo sapiens
76 CCDC85A  
Affinity Capture-MS Homo sapiens
77 LZTS2 84445
Affinity Capture-MS Homo sapiens
78 MYC  
Affinity Capture-MS Homo sapiens
79 RAB11B 9230
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 RAB11FIP2  
Affinity Capture-Western Homo sapiens
81 CCDC101  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 RHOB 388
Proximity Label-MS Homo sapiens
83 TBCA 6902
Co-fractionation Homo sapiens
84 PDP1 54704
Co-fractionation Homo sapiens
85 HINT1 3094
Co-fractionation Homo sapiens
86 FOXK1 221937
Co-fractionation Homo sapiens
87 BRD3 8019
Affinity Capture-MS Homo sapiens
88 RAB7A 7879
Proximity Label-MS Homo sapiens
89 FLOT1 10211
Proximity Label-MS Homo sapiens
90 WDR47  
Affinity Capture-MS Homo sapiens
91 PIGR 5284
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
92 SUMO1 7341
Co-fractionation Homo sapiens
93 DENND6A 201627
Proximity Label-MS Homo sapiens
94 GRK5 2869
Affinity Capture-MS Homo sapiens
95 ARRB2 409
Affinity Capture-MS Homo sapiens
96 KLHL15  
Affinity Capture-MS Homo sapiens
97 GIPC1 10755
Co-fractionation Homo sapiens
98 PDZD2  
Co-fractionation Homo sapiens
99 ABCB8 11194
Co-fractionation Homo sapiens
100 HAUS1  
Affinity Capture-MS Homo sapiens
101 MTPN 136319
Co-fractionation Homo sapiens
102 RNPS1 10921
Affinity Capture-MS Homo sapiens
103 ERH 2079
Co-fractionation Homo sapiens
104 PCMT1 5110
Co-fractionation Homo sapiens
105 ISCA2 122961
Affinity Capture-MS Homo sapiens
106 GABARAPL2 11345
Co-fractionation Homo sapiens
107 BID  
Co-fractionation Homo sapiens
108 KLHL8  
Affinity Capture-MS Homo sapiens
109 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 C21orf33  
Co-fractionation Homo sapiens
111 RAB11FIP1 80223
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
112 RPL34 6164
Affinity Capture-MS Homo sapiens
113 HDGFRP2 84717
Affinity Capture-MS Homo sapiens
114 ARRB1 408
Affinity Capture-MS Homo sapiens
115 UPF1 5976
Co-fractionation Homo sapiens
116 ZCCHC10  
Affinity Capture-MS Homo sapiens
117 RAB11A 8766
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
118 EPHA2 1969
Proximity Label-MS Homo sapiens
119 KRAS 3845
Proximity Label-MS Homo sapiens
120 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
121 PPP2R2A 5520
Affinity Capture-MS Homo sapiens
122 CAV1 857
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RAB11FIP5 is involved
No pathways found





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