Gene description for TBK1
Gene name TANK-binding kinase 1
Gene symbol TBK1
Other names/aliases NAK
T2K
Species Homo sapiens
 Database cross references - TBK1
ExoCarta ExoCarta_29110
Vesiclepedia VP_29110
Entrez Gene 29110
HGNC 11584
MIM 604834
UniProt Q9UHD2  
 TBK1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for TBK1
Molecular Function
    nucleic acid binding GO:0003676 IEA
    protein kinase activity GO:0004672 NAS
    protein serine/threonine kinase activity GO:0004674 EXP
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein phosphatase binding GO:0019903 ISS
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    identical protein binding GO:0042802 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    phosphoprotein binding GO:0051219 IPI
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    activation of innate immune response GO:0002218 IBA
    activation of innate immune response GO:0002218 IDA
    cytoplasmic pattern recognition receptor signaling pathway GO:0002753 IDA
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    inflammatory response GO:0006954 TAS
    canonical NF-kappaB signal transduction GO:0007249 TAS
    response to virus GO:0009615 TAS
    positive regulation of autophagy GO:0010508 IDA
    negative regulation of gene expression GO:0010629 IEA
    macroautophagy GO:0016236 TAS
    positive regulation of macroautophagy GO:0016239 IDA
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    regulation of type I interferon production GO:0032479 IDA
    positive regulation of type I interferon production GO:0032481 IBA
    positive regulation of type I interferon production GO:0032481 IDA
    positive regulation of type I interferon production GO:0032481 TAS
    positive regulation of interferon-alpha production GO:0032727 IDA
    positive regulation of interferon-beta production GO:0032728 IDA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 NAS
    toll-like receptor 4 signaling pathway GO:0034142 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEP
    dendritic cell proliferation GO:0044565 IEA
    innate immune response GO:0045087 IDA
    innate immune response GO:0045087 TAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    defense response to Gram-positive bacterium GO:0050830 IEA
    defense response to virus GO:0051607 NAS
    type I interferon-mediated signaling pathway GO:0060337 NAS
    positive regulation of type I interferon-mediated signaling pathway GO:0060340 IEA
    T follicular helper cell differentiation GO:0061470 IDA
    antiviral innate immune response GO:0140374 IDA
    cGAS/STING signaling pathway GO:0140896 TAS
    negative regulation of TORC1 signaling GO:1904262 IDA
    positive regulation of TORC1 signaling GO:1904263 IDA
    positive regulation of xenophagy GO:1904417 IEA
    positive regulation of TORC2 signaling GO:1904515 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cytosol GO:0005829 TAS
    intracellular membrane-bounded organelle GO:0043231 IDA
    serine/threonine protein kinase complex GO:1902554 NAS
 Experiment description of studies that identified TBK1 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 217
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TBK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAIP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 EIF4B 1975
Affinity Capture-MS Homo sapiens
3 TNFAIP3 7128
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 TRAF3IP3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 TNIP1 10318
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 HOOK1  
Proximity Label-MS Homo sapiens
7 XIAP  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
8 TLR3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 BLOC1S6  
Affinity Capture-MS Homo sapiens
10 D2HGDH 728294
Affinity Capture-MS Homo sapiens
11 ATG9A 79065
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
12 S100A6 6277
Affinity Capture-MS Homo sapiens
13 FMR1 2332
Affinity Capture-MS Homo sapiens
14 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
15 REL 5966
Affinity Capture-MS Homo sapiens
16 MTPAP 55149
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
17 CTNNBL1 56259
Affinity Capture-Western Homo sapiens
18 PROS1 5627
Two-hybrid Homo sapiens
19 APBA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 STX4 6810
Proximity Label-MS Homo sapiens
21 ANKRD28 23243
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 STX11 8676
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 APP 351
Reconstituted Complex Homo sapiens
24 HMMR  
Affinity Capture-MS Homo sapiens
25 LGALS3BP 3959
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 MAP1LC3B 81631
Reconstituted Complex Homo sapiens
27 VANGL2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 KRTAP19-7  
Affinity Capture-MS Homo sapiens
29 WDR48 57599
Affinity Capture-Western Homo sapiens
30 PPP6C 5537
Affinity Capture-MS Homo sapiens
31 DTX4 23220
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
32 PELI1 57162
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
33 MCM2 4171
Affinity Capture-MS Homo sapiens
34 DYRK2 8445
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 S100P 6286
Affinity Capture-MS Homo sapiens
36 PTPN23 25930
Proximity Label-MS Homo sapiens
37 FZR1  
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
38 FBXW7  
Affinity Capture-MS Homo sapiens
39 BBOX1 8424
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 SRC 6714
Affinity Capture-Western Homo sapiens
41 SYK 6850
Affinity Capture-Western Homo sapiens
42 CALCOCO2  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
43 IFIT3 3437
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 IKBKE 9641
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
45 MBP 4155
Biochemical Activity Homo sapiens
46 HERC2 8924
Affinity Capture-MS Homo sapiens
47 CENPQ  
Affinity Capture-MS Homo sapiens
48 ATG16L1 55054
Affinity Capture-MS Homo sapiens
49 POLR2C 5432
Proximity Label-MS Homo sapiens
50 PPP6R1 22870
Affinity Capture-MS Homo sapiens
51 BET1 10282
Affinity Capture-MS Homo sapiens
52 USP2  
Affinity Capture-Western Homo sapiens
53 MAVS 57506
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
54 SOCS3 9021
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
55 BTRC 8945
Affinity Capture-MS Homo sapiens
56 NCK1 4690
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
57 NEDD4 4734
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
58 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 GSK3B 2932
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 RNF11 26994
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
61 TNF  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
62 CDC42BPG 55561
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
63 EXOC2 55770
Affinity Capture-Western Homo sapiens
64 XPO1 7514
Affinity Capture-MS Homo sapiens
65 TOLLIP 54472
Affinity Capture-Western Homo sapiens
66 USP15 9958
Affinity Capture-Western Homo sapiens
67 SULT1C4  
Affinity Capture-MS Homo sapiens
68 MIB1 57534
Biochemical Activity Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
69 TRIM26 7726
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 PRPH 5630
Proximity Label-MS Homo sapiens
71 CXCL1 2919
Affinity Capture-MS Homo sapiens
72 RB1CC1 9821
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
73 PARK2  
Affinity Capture-MS Homo sapiens
74 PPP6R2 9701
Affinity Capture-MS Homo sapiens
75 OPTN 10133
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
76 IRF7  
Reconstituted Complex Homo sapiens
77 DIABLO 56616
Affinity Capture-MS Homo sapiens
78 AZI2  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
79 TRIM14 9830
Affinity Capture-Western Homo sapiens
80 HIF1AN 55662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 TXLNG  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
82 PBXIP1 57326
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
83 TRIM21 6737
Affinity Capture-MS Homo sapiens
84 NTRK1 4914
Affinity Capture-MS Homo sapiens
85 PLK1 5347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 BICD2 23299
Proximity Label-MS Homo sapiens
87 TICAM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
88 NFKB2 4791
Affinity Capture-MS Homo sapiens
89 LATS2 26524
Proximity Label-MS Homo sapiens
90 CYLD  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
91 TRIM23 373
Affinity Capture-Western Homo sapiens
92 UBE2S  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 PICK1  
Affinity Capture-MS Homo sapiens
94 PHIP 55023
Affinity Capture-MS Homo sapiens
95 PXN 5829
Proximity Label-MS Homo sapiens
96 TAX1BP1 8887
Affinity Capture-Western Homo sapiens
97 TBKBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
98 PIP 5304
Affinity Capture-MS Homo sapiens
99 RELA 5970
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
100 LETM1 3954
Affinity Capture-MS Homo sapiens
101 TRIM10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 RNF128  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
103 NFKBIA  
Biochemical Activity Homo sapiens
104 TXLNB  
Affinity Capture-MS Homo sapiens
105 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
106 CUL3 8452
Affinity Capture-MS Homo sapiens
107 EGFR 1956
Affinity Capture-MS Homo sapiens
108 NACC1 112939
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
109 CUL1 8454
Affinity Capture-MS Homo sapiens
110 TRAF3 7187
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
111 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
112 TOMM70A 9868
Affinity Capture-Western Homo sapiens
113 TMEM173  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
114 CRYBB3  
Affinity Capture-MS Homo sapiens
115 Trim11  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
116 RPA3 6119
Proximity Label-MS Homo sapiens
117 NIN 51199
Proximity Label-MS Homo sapiens
118 ARL4D  
Affinity Capture-MS Homo sapiens
119 SEC16A 9919
Affinity Capture-Western Homo sapiens
120 HVCN1 84329
Affinity Capture-MS Homo sapiens
121 TRIM27  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
122 USP19 10869
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 HSP90AA2P 3324
Affinity Capture-MS Homo sapiens
124 NFKB1 4790
Affinity Capture-MS Homo sapiens
125 BICD1 636
Proximity Label-MS Homo sapiens
126 AMOT 154796
Proximity Label-MS Homo sapiens
127 LGALS8 3964
Affinity Capture-MS Homo sapiens
128 AKT1 207
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
129 RBBP5 5929
Affinity Capture-MS Homo sapiens
130 TLR4  
Affinity Capture-Western Homo sapiens
131 IRAK3 11213
Affinity Capture-MS Homo sapiens
132 IRF3 3661
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
133 ICOS  
Affinity Capture-Western Homo sapiens
134 NAA10 8260
Affinity Capture-MS Homo sapiens
135 CCDC8  
Affinity Capture-MS Homo sapiens
136 ACBD5 91452
Proximity Label-MS Homo sapiens
137 TXLNA 200081
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
138 KRT18 3875
Proximity Label-MS Homo sapiens
139 TRAF7  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
140 METTL21B  
Affinity Capture-MS Homo sapiens
141 STX19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 TANK 10010
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
143 TRAF3IP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
144 CDC20 991
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
145 TRAF2 7186
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
146 DFNB31  
Affinity Capture-MS Homo sapiens
147 PTPRD 5789
Reconstituted Complex Homo sapiens
148 USP1 7398
Affinity Capture-Western Homo sapiens
149 CDC37 11140
Affinity Capture-MS Homo sapiens
150 IKBKG 8517
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
151 EDEM1  
Affinity Capture-MS Homo sapiens
152 SKP1 6500
Affinity Capture-MS Homo sapiens
153 NCOA2 10499
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
154 SMURF1 57154
Biochemical Activity Homo sapiens
155 SQSTM1 8878
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
156 DCTN2 10540
Proximity Label-MS Homo sapiens
157 TRIM9  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
158 NLRP4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
159 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
160 FILIP1  
Affinity Capture-MS Homo sapiens
161 AGO2 27161
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
162 DDX58 23586
Affinity Capture-Western Homo sapiens
163 ESR1  
Affinity Capture-Western Homo sapiens
164 TLR9  
Affinity Capture-Western Homo sapiens
165 MIF 4282
Affinity Capture-MS Homo sapiens
166 TBK1 29110
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-crystal Structure Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
167 LRRC10B  
Affinity Capture-MS Homo sapiens
168 KRT8 3856
Proximity Label-MS Homo sapiens
169 STX3 6809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 CEP135  
Proximity Label-MS Homo sapiens
171 PSMF1 9491
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
172 BRD1 23774
Affinity Capture-MS Homo sapiens
173 MIB2 142678
Biochemical Activity Homo sapiens
174 NDC80 10403
Proximity Label-MS Homo sapiens
175 FXR2 9513
Affinity Capture-MS Homo sapiens
176 C17orf59 54785
Proximity Label-MS Homo sapiens
177 MAP4K1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
178 TRAF1 7185
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TBK1 is involved
PathwayEvidenceSource
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) TAS Reactome
Autophagy TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytosolic sensors of pathogen-associated DNA TAS Reactome
Cytosolic sensors of pathogen-associated DNA IEA Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta TAS Reactome
Death Receptor Signaling TAS Reactome
Disease TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-37 signaling TAS Reactome
IRF3 mediated activation of type 1 IFN TAS Reactome
IRF3 mediated activation of type 1 IFN IEA Reactome
IRF3-mediated induction of type I IFN TAS Reactome
Macroautophagy TAS Reactome
Mitophagy TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
Negative regulators of DDX58/IFIH1 signaling TAS Reactome
PINK1-PRKN Mediated Mitophagy TAS Reactome
Potential therapeutics for SARS TAS Reactome
Regulation of innate immune responses to cytosolic DNA TAS Reactome
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 TAS Reactome
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation TAS Reactome
Regulation of TNFR1 signaling TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-1 activates/modulates innate immune responses TAS Reactome
SARS-CoV-1 Infection TAS Reactome
SARS-CoV-1-host interactions TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
Selective autophagy TAS Reactome
Signal Transduction TAS Reactome
Signaling by Interleukins TAS Reactome
STAT6-mediated induction of chemokines TAS Reactome
STING mediated induction of host immune responses TAS Reactome
TICAM1-dependent activation of IRF3/IRF7 TAS Reactome
TNF signaling TAS Reactome
TNFR1-induced proapoptotic signaling TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF3-dependent IRF activation pathway TAS Reactome
TRAF6 mediated IRF7 activation TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
Viral Infection Pathways TAS Reactome
ZBP1(DAI) mediated induction of type I IFNs TAS Reactome
ZBP1(DAI) mediated induction of type I IFNs IEA Reactome





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