Gene description for SV2A
Gene name synaptic vesicle glycoprotein 2A
Gene symbol SV2A
Other names/aliases SV2
Species Homo sapiens
 Database cross references - SV2A
ExoCarta ExoCarta_9900
Vesiclepedia VP_9900
Entrez Gene 9900
HGNC 20566
MIM 185860
UniProt Q7L0J3  
 SV2A identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SV2A
Molecular Function
    protein kinase binding GO:0019901 ISS
    transmembrane transporter activity GO:0022857 IEA
Biological Process
    intracellular calcium ion homeostasis GO:0006874 IEA
    regulation of gamma-aminobutyric acid secretion GO:0014052 IEA
    synaptic vesicle priming GO:0016082 IEA
    transmembrane transport GO:0055085 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IEA
    synaptic vesicle GO:0008021 TAS
    dendrite GO:0030425 IEA
    synaptic vesicle membrane GO:0030672 IBA
    synaptic vesicle membrane GO:0030672 TAS
    neuromuscular junction GO:0031594 IEA
    neuron projection GO:0043005 IBA
    neuronal cell body GO:0043025 IEA
    presynaptic active zone GO:0048786 IEA
    glutamatergic synapse GO:0098978 IEA
    GABA-ergic synapse GO:0098982 IEA
 Experiment description of studies that identified SV2A in exosomes
1
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SV2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UPK2 7379
Affinity Capture-MS Homo sapiens
2 STK39 27347
Affinity Capture-MS Homo sapiens
3 ATXN1 6310
Two-hybrid Homo sapiens
4 GK  
Affinity Capture-MS Homo sapiens
5 RAB3B 5865
Affinity Capture-MS Homo sapiens
6 MTFP1  
Affinity Capture-MS Homo sapiens
7 WDR11 55717
Affinity Capture-MS Homo sapiens
8 TP53 7157
Affinity Capture-MS Homo sapiens
9 MICU2 221154
Affinity Capture-MS Homo sapiens
10 SELT 51714
Affinity Capture-MS Homo sapiens
11 LAMTOR1 55004
Proximity Label-MS Homo sapiens
12 HSD17B7 51478
Affinity Capture-MS Homo sapiens
13 JPH1 56704
Affinity Capture-MS Homo sapiens
14 RAB5A 5868
Proximity Label-MS Homo sapiens
15 KCTD10 83892
Affinity Capture-MS Homo sapiens
16 ORMDL3 94103
Affinity Capture-MS Homo sapiens
17 PXMP2  
Affinity Capture-MS Homo sapiens
18 ATG9A 79065
Proximity Label-MS Homo sapiens
19 ACTA2 59
Affinity Capture-MS Homo sapiens
20 CLEC2D  
Affinity Capture-MS Homo sapiens
21 TUBB8 347688
Affinity Capture-MS Homo sapiens
22 TRIM66  
Affinity Capture-MS Homo sapiens
23 EXTL3 2137
Affinity Capture-MS Homo sapiens
24 CHEK2  
Affinity Capture-MS Homo sapiens
25 C17orf75 64149
Affinity Capture-MS Homo sapiens
26 B4GALT7 11285
Affinity Capture-MS Homo sapiens
27 ELOVL4  
Affinity Capture-MS Homo sapiens
28 RIPK4  
Affinity Capture-MS Homo sapiens
29 LTB4R2  
Two-hybrid Homo sapiens
30 ILVBL 10994
Affinity Capture-MS Homo sapiens
31 SPG7  
Affinity Capture-MS Homo sapiens
32 AP2M1 1173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 RAB4A 5867
Proximity Label-MS Homo sapiens
34 NR2F2  
Affinity Capture-MS Homo sapiens
35 SLC25A46 91137
Affinity Capture-MS Homo sapiens
36 B3GAT1  
Proximity Label-MS Homo sapiens
37 MCU 90550
Affinity Capture-MS Homo sapiens
38 NDUFB3 4709
Affinity Capture-MS Homo sapiens
39 FAM91A1 157769
Affinity Capture-MS Homo sapiens
40 SLC25A14  
Affinity Capture-MS Homo sapiens
41 TRIM21 6737
Affinity Capture-MS Homo sapiens
42 NTRK1 4914
Affinity Capture-MS Homo sapiens
43 RAB7A 7879
Proximity Label-MS Homo sapiens
44 RAB9A 9367
Proximity Label-MS Homo sapiens
45 SLC25A17 10478
Affinity Capture-MS Homo sapiens
46 BRD1 23774
Affinity Capture-MS Homo sapiens
47 RNASEL 6041
Affinity Capture-MS Homo sapiens
48 CCRN4L  
Affinity Capture-MS Homo sapiens
49 ADRB2  
Affinity Capture-MS Homo sapiens
50 RPN1 6184
Proximity Label-MS Homo sapiens
51 SLC25A30 253512
Affinity Capture-MS Homo sapiens
52 MTX3  
Affinity Capture-MS Homo sapiens
53 LGALS8 3964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 MICU1 10367
Affinity Capture-MS Homo sapiens
55 ELOVL5 60481
Proximity Label-MS Homo sapiens
56 GFPT2 9945
Affinity Capture-MS Homo sapiens
57 ADCK1  
Affinity Capture-MS Homo sapiens
58 FADS1 3992
Affinity Capture-MS Homo sapiens
59 GNL3L 54552
Affinity Capture-MS Homo sapiens
60 RAB11A 8766
Proximity Label-MS Homo sapiens
61 HELLS 3070
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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