Gene description for CACNA1E
Gene name calcium channel, voltage-dependent, R type, alpha 1E subunit
Gene symbol CACNA1E
Other names/aliases BII
CACH6
CACNL1A6
Cav2.3
Species Homo sapiens
 Database cross references - CACNA1E
ExoCarta ExoCarta_777
Entrez Gene 777
HGNC 1392
MIM 601013
UniProt Q15878  
 CACNA1E identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CACNA1E
Molecular Function
    high voltage-gated calcium channel activity GO:0008331 IBA
    voltage-gated calcium channel activity GO:0005245 IDA
    calcium ion binding GO:0005509 IEA
Biological Process
    transport GO:0006810 TAS
    ion transmembrane transport GO:0034220 IBA
    small molecule metabolic process GO:0044281 TAS
    membrane depolarization GO:0051899 TAS
    calcium ion transmembrane transport GO:0070588 IEA
    membrane depolarization during action potential GO:0086010 IBA
    regulation of ion transmembrane transport GO:0034765 IEA
    calcium ion transport GO:0006816 IBA
    synaptic transmission GO:0007268 TAS
    energy reserve metabolic process GO:0006112 TAS
    regulation of insulin secretion GO:0050796 TAS
    calcium ion import GO:0070509 IBA
Subcellular Localization
    voltage-gated calcium channel complex GO:0005891 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified CACNA1E in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CACNA1E
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EFHC1  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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