Gene description for NEDD4
Gene name	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Gene symbol	NEDD4
Other names/aliases	NEDD4-1 RPF1
Species	Homo sapiens
Database cross references - NEDD4
ExoCarta	ExoCarta_4734
Entrez Gene	4734
HGNC	7727
MIM	602278
UniProt	P46934
NEDD4 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	19837982
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Platelets	25332113
Platelets	25332113
Platelets	25332113
Prostate cancer cells	25844599

Gene ontology annotations for NEDD4

Molecular Function     beta-2 adrenergic receptor binding GO:0031698 IDA     phosphothreonine binding GO:0050816 ISS     sodium channel inhibitor activity GO:0019871 IDA     ubiquitin binding GO:0043130 IDA     proline-rich region binding GO:0070064 IPI     protein binding GO:0005515 IPI     ubiquitin protein ligase activity GO:0061630 IDA     ligase activity GO:0016874 IEA     phosphoserine binding GO:0050815 ISS     protein domain specific binding GO:0019904 IPI     RNA polymerase binding GO:0070063 IPI Biological Process     adaptive immune response GO:0002250 IEA     protein ubiquitination GO:0016567 IDA     endocardial cushion development GO:0003197 IEA     regulation of ion transmembrane transport GO:0034765 IDA     transmission of virus GO:0019089 IMP     negative regulation of sodium ion transmembrane transporter activity GO:2000650 IDA     T cell activation GO:0042110 IEA     cellular response to UV GO:0034644 IMP     regulation of dendrite morphogenesis GO:0048814 ISS     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IMP     receptor internalization GO:0031623 IDA     cytokine-mediated signaling pathway GO:0019221 TAS     progesterone receptor signaling pathway GO:0050847 IDA     development involved in symbiotic interaction GO:0044111 IMP     regulation of potassium ion transmembrane transporter activity GO:1901016 IDA     positive regulation of protein catabolic process GO:0045732 IDA     neuron projection development GO:0031175 IEP     negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage GO:0010768 IMP     positive regulation of nucleocytoplasmic transport GO:0046824 IDA     glucocorticoid receptor signaling pathway GO:0042921 IDA     protein targeting to lysosome GO:0006622 IDA     neuromuscular junction development GO:0007528 IEA     receptor catabolic process GO:0032801 IDA     protein K63-linked ubiquitination GO:0070534 ISS     response to calcium ion GO:0051592 TAS     regulation of membrane potential GO:0042391 IDA     protein monoubiquitination GO:0006513 IEA     ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IMP     outflow tract morphogenesis GO:0003151 IEA     negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 ISS     negative regulation of sodium ion transport GO:0010766 IDA     protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IMP     blood vessel morphogenesis GO:0048514 IEA     lysosomal transport GO:0007041 IDA     regulation of synapse organization GO:0050807 IEA Subcellular Localization     ubiquitin ligase complex GO:0000151 ISS     chromatin GO:0000785 IDA     plasma membrane GO:0005886 IMP     perinuclear region of cytoplasm GO:0048471 IDA     cytosol GO:0005829 TAS     Golgi apparatus GO:0005794 IDA     cell cortex GO:0005938 IDA     cytoplasm GO:0005737 IDA     extracellular exosome GO:0070062 IDA     apicolateral plasma membrane GO:0016327 TAS