Gene description for ABL1
Gene name ABL proto-oncogene 1, non-receptor tyrosine kinase
Gene symbol ABL1
Other names/aliases ABL
JTK7
bcr/abl
c-ABL
c-ABL1
p150
v-abl
Species Homo sapiens
 Database cross references - ABL1
ExoCarta ExoCarta_25
Entrez Gene 25
HGNC 76
MIM 189980
UniProt P00519  
 ABL1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for ABL1
Molecular Function
    protein binding GO:0005515 IPI
    nicotinate-nucleotide adenylyltransferase activity GO:0004515 TAS
    receptor binding GO:0005102 IBA
    protein C-terminus binding GO:0008022 IPI
    magnesium ion binding GO:0000287 IDA
    SH3 domain binding GO:0017124 IPI
    DNA binding GO:0003677 NAS
    manganese ion binding GO:0030145 IDA
    proline-rich region binding GO:0070064 IPI
    protein tyrosine kinase activity GO:0004713 IDA
    actin monomer binding GO:0003785 TAS
    syntaxin binding GO:0019905 IPI
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    protein kinase activity GO:0004672 IDA
    mitogen-activated protein kinase binding GO:0051019 IPI
    ATP binding GO:0005524 IDA
    actin filament binding GO:0051015 IEA
Biological Process
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IEA
    positive regulation of mitotic cell cycle GO:0045931 IEA
    B cell proliferation involved in immune response GO:0002322 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IMP
    muscle cell differentiation GO:0042692 TAS
    regulation of cell motility GO:2000145 TAS
    axon guidance GO:0007411 TAS
    cerebellum morphogenesis GO:0021587 IEA
    response to oxidative stress GO:0006979 IGI
    B-1 B cell homeostasis GO:0001922 IEA
    positive regulation of apoptotic process GO:0043065 IDA
    cell migration GO:0016477 IBA
    regulation of actin cytoskeleton reorganization GO:2000249 TAS
    substrate adhesion-dependent cell spreading GO:0034446 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 TAS
    actin filament branching GO:0090135 IEA
    activated T cell proliferation GO:0050798 IEA
    regulation of cell proliferation GO:0042127 IBA
    positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IEA
    spleen development GO:0048536 IEA
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA
    regulation of extracellular matrix organization GO:1903053 IEA
    blood coagulation GO:0007596 TAS
    mismatch repair GO:0006298 TAS
    regulation of cell adhesion GO:0030155 TAS
    DNA damage induced protein phosphorylation GO:0006975 IDA
    negative regulation of endothelial cell apoptotic process GO:2000352 IEA
    negative regulation of BMP signaling pathway GO:0030514 IEA
    regulation of transcription, DNA-templated GO:0006355 TAS
    actin cytoskeleton organization GO:0030036 ISS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    microspike assembly GO:0030035 IEA
    cellular response to dopamine GO:1903351 TAS
    alpha-beta T cell differentiation GO:0046632 IEA
    positive regulation of oxidoreductase activity GO:0051353 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 TAS
    regulation of response to DNA damage stimulus GO:2001020 IDA
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEA
    negative regulation of protein serine/threonine kinase activity GO:0071901 IDA
    Bergmann glial cell differentiation GO:0060020 IEA
    platelet-derived growth factor receptor signaling pathway GO:0048008 IBA
    cellular response to lipopolysaccharide GO:0071222 IEA
    cellular response to oxidative stress GO:0034599 TAS
    mitotic nuclear division GO:0007067 TAS
    collateral sprouting GO:0048668 IEA
    positive regulation of interleukin-2 secretion GO:1900042 IEA
    negative regulation of cell-cell adhesion GO:0022408 IEA
    positive regulation of neuron death GO:1901216 IEA
    signal transduction in response to DNA damage GO:0042770 IDA
    innate immune response GO:0045087 TAS
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA
    transitional one stage B cell differentiation GO:0002333 IEA
    negative regulation of mitotic cell cycle GO:0045930 IEA
    small GTPase mediated signal transduction GO:0007264 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    negative regulation of phospholipase C activity GO:1900275 IMP
    cell differentiation GO:0030154 IBA
    peptidyl-tyrosine autophosphorylation GO:0038083 IDA
    negative regulation of ubiquitin-protein transferase activity GO:0051444 TAS
    negative regulation of cellular senescence GO:2000773 IEA
    cell cycle arrest GO:0007050 TAS
    cellular response to DNA damage stimulus GO:0006974 IDA
    mitochondrial depolarization GO:0051882 TAS
    B cell receptor signaling pathway GO:0050853 IEA
    positive regulation of interferon-gamma secretion GO:1902715 IEA
    thymus development GO:0048538 IEA
    autophagy GO:0006914 IEA
    cellular protein modification process GO:0006464 NAS
    positive regulation of muscle cell differentiation GO:0051149 TAS
    regulation of endocytosis GO:0030100 TAS
    positive regulation of protein phosphorylation GO:0001934 IMP
    epidermal growth factor receptor signaling pathway GO:0007173 IBA
    neuromuscular process controlling balance GO:0050885 IEA
    positive regulation of osteoblast proliferation GO:0033690 IEA
    regulation of autophagy GO:0010506 TAS
Subcellular Localization
    cell leading edge GO:0031252 IEA
    nucleus GO:0005634 TAS
    actin cytoskeleton GO:0015629 TAS
    nucleolus GO:0005730 IDA
    nuclear membrane GO:0031965 IEA
    cytoplasm GO:0005737 TAS
    mitochondrion GO:0005739 NAS
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA
    perinuclear region of cytoplasm GO:0048471 IDA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified ABL1 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ABL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATR  
Protein-peptide Homo sapiens
2 ARHGAP17 55114
Reconstituted Complex Homo sapiens
3 CAT 847
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
4 SH3BP1  
Invitro Homo sapiens
5 ABL2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 ZDHHC16  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
7 SPTAN1 6709
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
8 NCK1 4690
Invivo Homo sapiens
9 TP53  
Reconstituted Complex Homo sapiens
10 Jak1 16451
Affinity Capture-Western Mus musculus
11 GRB2 2885
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
12 SHC1 6464
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 SORBS1 10580
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
14 CABLES2  
Affinity Capture-Western Homo sapiens
15 INPPL1 3636
Affinity Capture-Western Homo sapiens
16 GPX1 2876
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 PTPN6 5777
Affinity Capture-Western Homo sapiens
18 NEDD9 4739
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
19 EPHB2 2048
Invivo Homo sapiens
Two-hybrid Homo sapiens
20 SLC9A2  
Reconstituted Complex Homo sapiens
21 BCAR1 9564
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
22 PAK2 5062
Invivo Homo sapiens
23 BRCA1 672
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
24 RAD9A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
25 VAV1 7409
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
26 SPTA1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 ABL1 25
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
28 YT521  
Biochemical Activity Homo sapiens
29 SORBS2  
Invivo Homo sapiens
Invivo Homo sapiens
30 GRB10 2887
Affinity Capture-Western Homo sapiens
31 PSTPIP1 9051
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
32 HCK 3055
Affinity Capture-Western Homo sapiens
33 TUB  
Invivo Homo sapiens
Invitro Homo sapiens
34 ADAM15 8751
Invitro Homo sapiens
Invivo Homo sapiens
35 EVL 51466
Reconstituted Complex Homo sapiens
36 TP73  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 RIN1  
Invitro Homo sapiens
38 PAG1  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
39 SHD  
Two-hybrid Homo sapiens
40 CBL 867
Invivo Homo sapiens
Invitro Homo sapiens
41 YTHDC1  
Affinity Capture-Western Homo sapiens
42 RB1 5925
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
43 ABI2 10152
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 DOK1 1796
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
45 CREB1  
Reconstituted Complex Homo sapiens
46 TERF1 7013
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 MDM2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
48 NTRK1  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 JAK1 3716
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
50 RAN 5901
Invivo Homo sapiens
51 RYBP  
Invitro Homo sapiens
Two-hybrid Homo sapiens
52 CRKL 1399
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
53 PXN 5829
Invivo Homo sapiens
54 MTOR 2475
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
55 Grap2  
Reconstituted Complex Mus musculus
56 ZAP70 7535
Affinity Capture-Western Homo sapiens
57 XRCC6 2547
Invivo Homo sapiens
58 PIK3R1 5295
Reconstituted Complex Homo sapiens
59 Creb1  
Affinity Capture-Western Mus musculus
60 ABI1 10006
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
61 RFX1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
62 SOS1  
Affinity Capture-Western Homo sapiens
63 ARGBP2  
Invivo Homo sapiens
Invitro Homo sapiens
64 RAD51  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
65 ST5 6764
Reconstituted Complex Homo sapiens
66 ATM  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
67 PRKDC 5591
Reconstituted Complex Homo sapiens
68 BCR 613
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
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