Gene description for GGA3
Gene name golgi-associated, gamma adaptin ear containing, ARF binding protein 3
Gene symbol GGA3
Other names/aliases -
Species Homo sapiens
 Database cross references - GGA3
ExoCarta ExoCarta_23163
Entrez Gene 23163
HGNC 17079
MIM 606006
UniProt Q9NZ52  
 GGA3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for GGA3
Molecular Function
    ADP-ribosylation factor binding GO:0030306 IDA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of protein catabolic process GO:0045732 IEA
    vesicle-mediated transport GO:0016192 IEA
    intracellular protein transport GO:0006886 NAS
Subcellular Localization
    clathrin adaptor complex GO:0030131 IEA
    trans-Golgi network GO:0005802 IDA
    endosome membrane GO:0010008 IEA
 Experiment description of studies that identified GGA3 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for GGA3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 M6PR 4074
Two-hybrid Homo sapiens
2 CLTC 1213
Reconstituted Complex Homo sapiens
3 TSG101 7251
Two-hybrid Homo sapiens
4 ARF3 377
Two-hybrid Homo sapiens
5 RABEP1  
Two-hybrid Homo sapiens
6 RAB5A 5868
Two-hybrid Homo sapiens
7 ARF1 375
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GGA3 is involved
No pathways found

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