Gene description for AKT1
Gene name	v-akt murine thymoma viral oncogene homolog 1
Gene symbol	AKT1
Other names/aliases	AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA
Species	Homo sapiens
Database cross references - AKT1
ExoCarta	ExoCarta_207
Entrez Gene	207
HGNC	391
MIM	164730
UniProt	P31749
AKT1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723
Nasopharyngeal carcinoma cells	21059916
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for AKT1

Molecular Function     protein serine/threonine kinase activity GO:0004674 TAS     identical protein binding GO:0042802 IPI     protein serine/threonine/tyrosine kinase activity GO:0004712 IDA     ATP binding GO:0005524 IDA     14-3-3 protein binding GO:0071889 IPI     protein kinase activity GO:0004672 TAS     enzyme binding GO:0019899 ISS     phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IDA     kinase activity GO:0016301 IDA     nitric-oxide synthase regulator activity GO:0030235 IMP     protein kinase C binding GO:0005080 IEA     phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IDA     protein binding GO:0005515 IPI Biological Process     cellular response to organic cyclic compound GO:0071407 IEA     cellular response to epidermal growth factor stimulus GO:0071364 IEA     positive regulation of glucose import GO:0046326 IMP     intrinsic apoptotic signaling pathway GO:0097193 TAS     phosphorylation GO:0016310 IDA     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     glycogen biosynthetic process GO:0005978 IEA     programmed cell death GO:0012501 TAS     positive regulation of cell growth GO:0030307 IDA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     protein phosphorylation GO:0006468 IDA     response to food GO:0032094 IEA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     cellular response to mechanical stimulus GO:0071260 IEA     protein import into nucleus, translocation GO:0000060 IMP     negative regulation of protein kinase activity GO:0006469 ISS     protein autophosphorylation GO:0046777 TAS     phosphatidylinositol-mediated signaling GO:0048015 TAS     glycogen cell differentiation involved in embryonic placenta development GO:0060709 IEA     glucose transport GO:0015758 IEA     negative regulation of fatty acid beta-oxidation GO:0031999 IMP     response to fluid shear stress GO:0034405 IMP     cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 IEA     mammary gland epithelial cell differentiation GO:0060644 TAS     striated muscle cell differentiation GO:0051146 IEA     negative regulation of apoptotic process GO:0043066 IDA     cellular protein modification process GO:0006464 TAS     response to insulin-like growth factor stimulus GO:1990418 ISS     small molecule metabolic process GO:0044281 TAS     negative regulation of neuron death GO:1901215 NAS     peripheral nervous system myelin maintenance GO:0032287 IEA     cell projection organization GO:0030030 IEA     cellular response to hypoxia GO:0071456 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     positive regulation of vasoconstriction GO:0045907 IEA     intracellular signal transduction GO:0035556 IDA     aging GO:0007568 IEA     glucose homeostasis GO:0042593 IEA     positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 IDA     positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 TAS     peptidyl-serine phosphorylation GO:0018105 IDA     insulin receptor signaling pathway GO:0008286 IMP     response to oxidative stress GO:0006979 ISS     inflammatory response GO:0006954 IEA     protein kinase B signaling GO:0043491 IEA     protein catabolic process GO:0030163 IEA     labyrinthine layer blood vessel development GO:0060716 IEA     regulation of myelination GO:0031641 IEA     signal transduction GO:0007165 TAS     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 NAS     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA     protein ubiquitination GO:0016567 IEA     positive regulation of establishment of protein localization to plasma membrane GO:0090004 IMP     response to UV-A GO:0070141 IDA     positive regulation of protein phosphorylation GO:0001934 IDA     G-protein coupled receptor signaling pathway GO:0007186 TAS     positive regulation of endothelial cell proliferation GO:0001938 IMP     positive regulation of lipid biosynthetic process GO:0046889 IMP     response to heat GO:0009408 TAS     negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 TAS     platelet activation GO:0030168 TAS     regulation of translation GO:0006417 IEA     regulation of neuron projection development GO:0010975 ISS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA     regulation of cell cycle checkpoint GO:1901976 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     positive regulation of glycogen biosynthetic process GO:0045725 NAS     maternal placenta development GO:0001893 IEA     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     response to growth hormone GO:0060416 ISS     apoptotic process GO:0006915 TAS     negative regulation of cell size GO:0045792 IEA     hyaluronan metabolic process GO:0030212 IEA     positive regulation of blood vessel endothelial cell migration GO:0043536 IDA     innate immune response GO:0045087 TAS     regulation of glycogen biosynthetic process GO:0005979 IMP     germ cell development GO:0007281 IEA     positive regulation of nitric oxide biosynthetic process GO:0045429 IMP     negative regulation of plasma membrane long-chain fatty acid transport GO:0010748 IMP     negative regulation of autophagy GO:0010507 IMP     apoptotic mitochondrial changes GO:0008637 IEA     negative regulation of endopeptidase activity GO:0010951 IMP     positive regulation of glucose metabolic process GO:0010907 IMP     negative regulation of proteolysis GO:0045861 IMP     blood coagulation GO:0007596 TAS     positive regulation of cellular protein metabolic process GO:0032270 ISS     translation GO:0006412 IEA     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IDA     activation-induced cell death of T cells GO:0006924 IMP     insulin-like growth factor receptor signaling pathway GO:0048009 IMP     execution phase of apoptosis GO:0097194 IEA     T cell costimulation GO:0031295 TAS     regulation of nitric-oxide synthase activity GO:0050999 TAS     positive regulation of fat cell differentiation GO:0045600 IMP     nitric oxide metabolic process GO:0046209 TAS     negative regulation of release of cytochrome c from mitochondria GO:0090201 ISS     cell differentiation GO:0030154 TAS     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISS     cell proliferation GO:0008283 TAS     nitric oxide biosynthetic process GO:0006809 TAS     positive regulation of nitric-oxide synthase activity GO:0051000 IMP     negative regulation of JNK cascade GO:0046329 IEA     gene expression GO:0010467 TAS     positive regulation of sodium ion transport GO:0010765 IEA     glucose metabolic process GO:0006006 IEA     endocrine pancreas development GO:0031018 TAS     osteoblast differentiation GO:0001649 IEA     membrane organization GO:0061024 TAS     cellular response to insulin stimulus GO:0032869 ISS     regulation of cell migration GO:0030334 TAS Subcellular Localization     mitochondrion GO:0005739 IEA     spindle GO:0005819 IEA     cell-cell junction GO:0005911 IEA     cytoplasm GO:0005737 TAS     microtubule cytoskeleton GO:0015630 IDA     nucleus GO:0005634 TAS     ciliary basal body GO:0036064 IEA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 TAS     nucleoplasm GO:0005654 TAS