Gene description for AKT1
Gene name v-akt murine thymoma viral oncogene homolog 1
Gene symbol AKT1
Other names/aliases AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
Species Homo sapiens
 Database cross references - AKT1
ExoCarta ExoCarta_207
Vesiclepedia VP_207
Entrez Gene 207
HGNC 391
MIM 164730
UniProt P31749  
 AKT1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
Nasopharyngeal carcinoma cells 21059916    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for AKT1
Molecular Function
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 EXP
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 IMP
    protein serine/threonine kinase activity GO:0004674 ISS
    protein serine/threonine kinase activity GO:0004674 NAS
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein serine/threonine/tyrosine kinase activity GO:0004712 IDA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IDA
    ATP binding GO:0005524 IC
    ATP binding GO:0005524 IDA
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IDA
    kinase activity GO:0016301 IDA
    enzyme binding GO:0019899 ISS
    protein kinase binding GO:0019901 IEA
    nitric-oxide synthase regulator activity GO:0030235 IMP
    protein serine/threonine kinase inhibitor activity GO:0030291 ISS
    protein serine/threonine kinase inhibitor activity GO:0030291 TAS
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IDA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    14-3-3 protein binding GO:0071889 IPI
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    potassium channel activator activity GO:0099104 IDA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    osteoblast differentiation GO:0001649 IDA
    maternal placenta development GO:0001893 IEA
    positive regulation of protein phosphorylation GO:0001934 IDA
    positive regulation of endothelial cell proliferation GO:0001938 IMP
    cell migration involved in sprouting angiogenesis GO:0002042 IMP
    sphingosine-1-phosphate receptor signaling pathway GO:0003376 IMP
    glycogen biosynthetic process GO:0005978 IEA
    regulation of glycogen biosynthetic process GO:0005979 IMP
    glucose metabolic process GO:0006006 IEA
    chromatin remodeling GO:0006338 IEA
    regulation of translation GO:0006417 IEA
    protein phosphorylation GO:0006468 IDA
    protein phosphorylation GO:0006468 IDA
    negative regulation of protein kinase activity GO:0006469 IMP
    negative regulation of protein kinase activity GO:0006469 ISS
    protein import into nucleus GO:0006606 IMP
    nitric oxide biosynthetic process GO:0006809 TAS
    activation-induced cell death of T cells GO:0006924 IMP
    inflammatory response GO:0006954 IEA
    response to oxidative stress GO:0006979 ISS
    signal transduction GO:0007165 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 IDA
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    cell population proliferation GO:0008283 TAS
    insulin receptor signaling pathway GO:0008286 IMP
    insulin receptor signaling pathway GO:0008286 ISS
    apoptotic mitochondrial changes GO:0008637 IEA
    response to heat GO:0009408 IEA
    gene expression GO:0010467 IEA
    negative regulation of autophagy GO:0010507 IMP
    positive regulation of endothelial cell migration GO:0010595 IMP
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of gene expression GO:0010628 ISS
    negative regulation of long-chain fatty acid import across plasma membrane GO:0010748 IMP
    fibroblast migration GO:0010761 NAS
    positive regulation of fibroblast migration GO:0010763 IEA
    positive regulation of sodium ion transport GO:0010765 IEA
    positive regulation of glucose metabolic process GO:0010907 IMP
    negative regulation of endopeptidase activity GO:0010951 IMP
    regulation of neuron projection development GO:0010975 ISS
    negative regulation of macroautophagy GO:0016242 NAS
    phosphorylation GO:0016310 IDA
    protein ubiquitination GO:0016567 IEA
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    virus-mediated perturbation of host defense response GO:0019049 IDA
    cytokine-mediated signaling pathway GO:0019221 TAS
    mammalian oogenesis stage GO:0022605 IEA
    cell differentiation GO:0030154 TAS
    positive regulation of cell growth GO:0030307 IDA
    regulation of cell migration GO:0030334 IMP
    regulation of cell migration GO:0030334 TAS
    positive regulation of cell migration GO:0030335 IDA
    T cell costimulation GO:0031295 TAS
    negative regulation of protein ubiquitination GO:0031397 IMP
    regulation of myelination GO:0031641 IEA
    lipopolysaccharide-mediated signaling pathway GO:0031663 IEA
    TOR signaling GO:0031929 NAS
    negative regulation of fatty acid beta-oxidation GO:0031999 IMP
    positive regulation of endodeoxyribonuclease activity GO:0032079 IDA
    negative regulation of protein binding GO:0032091 IMP
    response to food GO:0032094 IEA
    peripheral nervous system myelin maintenance GO:0032287 IEA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IDA
    cellular response to insulin stimulus GO:0032869 IDA
    cellular response to insulin stimulus GO:0032869 IMP
    cellular response to insulin stimulus GO:0032869 ISS
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    response to fluid shear stress GO:0034405 IMP
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 IDA
    interleukin-18-mediated signaling pathway GO:0035655 IDA
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IEA
    cellular response to decreased oxygen levels GO:0036294 IEA
    glucose homeostasis GO:0042593 IEA
    regulation of apoptotic process GO:0042981 ISS
    negative regulation of apoptotic process GO:0043066 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA
    anoikis GO:0043276 NAS
    regulation of mRNA stability GO:0043488 TAS
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IDA
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IMP
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 TAS
    positive regulation of blood vessel endothelial cell migration GO:0043536 IDA
    positive regulation of nitric oxide biosynthetic process GO:0045429 IMP
    positive regulation of fat cell differentiation GO:0045600 IMP
    positive regulation of glycogen biosynthetic process GO:0045725 IMP
    positive regulation of glycogen biosynthetic process GO:0045725 NAS
    positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 IMP
    negative regulation of Notch signaling pathway GO:0045746 TAS
    negative regulation of proteolysis GO:0045861 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of D-glucose import GO:0046326 IMP
    positive regulation of organ growth GO:0046622 IEA
    protein autophosphorylation GO:0046777 TAS
    positive regulation of lipid biosynthetic process GO:0046889 IDA
    positive regulation of lipid biosynthetic process GO:0046889 IMP
    insulin-like growth factor receptor signaling pathway GO:0048009 IMP
    behavioral response to pain GO:0048266 IEA
    positive regulation of smooth muscle cell proliferation GO:0048661 IDA
    positive regulation of nitric-oxide synthase activity GO:0051000 IMP
    positive regulation of DNA-binding transcription factor activity GO:0051091 IDA
    striated muscle cell differentiation GO:0051146 IEA
    positive regulation of protein metabolic process GO:0051247 ISS
    excitatory postsynaptic potential GO:0060079 NAS
    response to growth hormone GO:0060416 ISS
    mammary gland epithelial cell differentiation GO:0060644 TAS
    labyrinthine layer blood vessel development GO:0060716 IEA
    response to UV-A GO:0070141 IDA
    response to growth factor GO:0070848 IDA
    cellular response to tumor necrosis factor GO:0071356 IEA
    cellular response to epidermal growth factor stimulus GO:0071364 IDA
    cellular response to prostaglandin E stimulus GO:0071380 IEA
    negative regulation of protein serine/threonine kinase activity GO:0071901 TAS
    establishment of protein localization to mitochondrion GO:0072655 IMP
    maintenance of protein location in mitochondrion GO:0072656 IMP
    cellular response to rapamycin GO:0072752 ISS
    negative regulation of release of cytochrome c from mitochondria GO:0090201 ISS
    cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 IEA
    execution phase of apoptosis GO:0097194 IEA
    regulation of postsynapse organization GO:0099175 IEA
    regulation of tRNA methylation GO:0110002 IDA
    cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 IMP
    negative regulation of protein localization to lysosome GO:0150033 IDA
    negative regulation of cGAS/STING signaling pathway GO:0160049 IDA
    positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IMP
    positive regulation of protein localization to nucleus GO:1900182 IMP
    cellular response to peptide GO:1901653 IEA
    regulation of signal transduction by p53 class mediator GO:1901796 TAS
    negative regulation of cilium assembly GO:1902018 IDA
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 NAS
    negative regulation of leukocyte cell-cell adhesion GO:1903038 IMP
    positive regulation of protein localization to plasma membrane GO:1903078 IMP
    negative regulation of protein maturation GO:1903318 ISS
    negative regulation of PERK-mediated unfolded protein response GO:1903898 ISS
    positive regulation of TORC1 signaling GO:1904263 IDA
    positive regulation of protein localization to endoplasmic reticulum GO:1905552 IDA
    cellular response to nerve growth factor stimulus GO:1990090 IMP
    response to insulin-like growth factor stimulus GO:1990418 ISS
    positive regulation of protein localization to cell surface GO:2000010 IEA
    regulation of type B pancreatic cell development GO:2000074 TAS
    negative regulation of cysteine-type endopeptidase activity GO:2000117 ISS
    negative regulation of lymphocyte migration GO:2000402 IMP
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISS
    cytoplasm GO:0005737 TAS
    mitochondrial intermembrane space GO:0005758 ISS
    spindle GO:0005819 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IEA
    cell cortex GO:0005938 NAS
    microtubule cytoskeleton GO:0015630 IDA
    membrane GO:0016020 IDA
    lamellipodium GO:0030027 NAS
    vesicle GO:0031982 IDA
    protein-containing complex GO:0032991 IDA
    ciliary basal body GO:0036064 IEA
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified AKT1 in sEVs
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
7
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 125
MISEV standards
Biophysical techniques
HSC70|GAPDH|FLOT2
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 21059916    
Organism Homo sapiens
Experiment description Human tumor virus utilizes exosomes for intercellular communication.
Authors "Meckes DG Jr, Shair KH, Marquitz AR, Kung CP, Edwards RH, Raab-Traub N."
Journal name PNAS
Publication year 2010
Sample Nasopharyngeal carcinoma cells
Sample name C666
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
9
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AKT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST2H2BE 8349
Biochemical Activity Homo sapiens
2 PPP2R4 5524
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
3 MATK  
Reconstituted Complex Homo sapiens
4 TBC1D4  
Biochemical Activity Homo sapiens
5 CMTM8  
Biochemical Activity Homo sapiens
6 SKI 6497
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
7 SHANK2 22941
Biochemical Activity Homo sapiens
8 TPM2 7169
Affinity Capture-MS Homo sapiens
9 SH3RF1  
Biochemical Activity Homo sapiens
10 BRCA1 672
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
11 APOE 348
Biochemical Activity Homo sapiens
12 AKT3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CSNK2A1 1457
Biochemical Activity Homo sapiens
14 VHL  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 KLHL3  
Biochemical Activity Homo sapiens
16 PRKDC 5591
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Negative Genetic Homo sapiens
17 CKB 1152
Affinity Capture-MS Homo sapiens
18 PPL 5493
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
19 HDAC3 8841
Affinity Capture-Western Homo sapiens
20 PPP1CB 5500
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 RAF1 5894
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
22 RNF8  
Affinity Capture-Western Homo sapiens
23 SRC 6714
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
24 KLRC1  
Biochemical Activity Homo sapiens
25 ABI1 10006
Biochemical Activity Homo sapiens
26 FXN  
Biochemical Activity Homo sapiens
27 DNAJB1 3337
Two-hybrid Homo sapiens
28 PPM1A 5494
Co-localization Homo sapiens
29 SFN 2810
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 BTRC 8945
Biochemical Activity Homo sapiens
31 RNF11 26994
Biochemical Activity Homo sapiens
32 BAG6 7917
Biochemical Activity Homo sapiens
33 CDKN1B 1027
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
34 PYGO2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
35 GMPPA 29926
Biochemical Activity Homo sapiens
36 MAPK8IP1 9479
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
37 TCOF1 6949
Affinity Capture-MS Homo sapiens
38 NCKIPSD 51517
Biochemical Activity Homo sapiens
39 SRPK2 6733
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
40 CTBP1 1487
Affinity Capture-Western Homo sapiens
41 OFD1 8481
Biochemical Activity Homo sapiens
42 TRMT61A 115708
Co-fractionation Homo sapiens
43 OTUD1 220213
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Co-localization Homo sapiens
44 ENO1 2023
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
45 DLC1 10395
Biochemical Activity Homo sapiens
46 MAPK8 5599
Biochemical Activity Homo sapiens
47 METTL1 4234
Biochemical Activity Homo sapiens
48 VCP 7415
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
49 PHLPP1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
50 RNF40 9810
Co-fractionation Homo sapiens
51 TRHDE 29953
Affinity Capture-MS Homo sapiens
52 GAB2 9846
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
53 SMAD3 4088
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
54 FOXO1  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
55 RQCD1 9125
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
56 PRKCZ 5590
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
57 SKP2  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
58 YWHAZ 7534
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
59 SHQ1  
Biochemical Activity Homo sapiens
60 CNKSR3 154043
Biochemical Activity Homo sapiens
61 FANCA  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
62 PI4K2B 55300
Two-hybrid Homo sapiens
63 RPA3 6119
Proximity Label-MS Homo sapiens
64 SIK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
65 HSPA4 3308
Affinity Capture-Western Homo sapiens
66 CARHSP1 23589
Reconstituted Complex Homo sapiens
67 ILK 3611
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
68 COX2 4513
Affinity Capture-Western Homo sapiens
69 PDZK1 5174
Affinity Capture-Western Homo sapiens
70 AKT1 207
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
71 TPM4 7171
Affinity Capture-MS Homo sapiens
72 VASP 7408
Affinity Capture-MS Homo sapiens
73 COMMD1 150684
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
74 YIF1B 90522
Biochemical Activity Homo sapiens
75 STUB1 10273
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
76 YBX1 4904
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
77 NSF 4905
Affinity Capture-MS Homo sapiens
78 RUVBL2 10856
Biochemical Activity Homo sapiens
79 ISCA2 122961
Biochemical Activity Homo sapiens
80 CDC37 11140
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
81 PPP1R11  
Biochemical Activity Homo sapiens
82 ITPR3 3710
Biochemical Activity Homo sapiens
83 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
84 MEF2D  
Biochemical Activity Homo sapiens
85 SIRT1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
86 LTB4R2  
Biochemical Activity Homo sapiens
87 TBK1 29110
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
88 GAPDH 2597
Affinity Capture-MS Homo sapiens
89 ALYREF 10189
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
90 SUPT6H 6830
Reconstituted Complex Homo sapiens
91 SPATA33  
Biochemical Activity Homo sapiens
92 KRT10 3858
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
93 ITPR1 3708
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
94 DNMT1 1786
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
95 NRIP2  
Biochemical Activity Homo sapiens
96 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
97 LDHA 3939
Affinity Capture-MS Homo sapiens
98 HBB 3043
Affinity Capture-MS Homo sapiens
99 TSC2 7249
Affinity Capture-Western Homo sapiens
100 UCHL1 7345
Affinity Capture-MS Homo sapiens
101 HSP90AB1 3326
Affinity Capture-Western Homo sapiens
102 FANCI 55215
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
103 EIF4A1 1973
Affinity Capture-MS Homo sapiens
104 TERF2IP 54386
Two-hybrid Homo sapiens
105 ASXL1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
106 SETDB1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
107 DNAJB6 10049
Affinity Capture-MS Homo sapiens
108 FAM175A  
Biochemical Activity Homo sapiens
109 ABHD15  
Affinity Capture-MS Homo sapiens
110 GPHN 10243
Affinity Capture-MS Homo sapiens
111 STOX1  
Biochemical Activity Homo sapiens
112 SOSTDC1  
Affinity Capture-Western Homo sapiens
113 NR2F2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 NPM1 4869
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
115 MAPK14 1432
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
116 ARFIP2 23647
Two-hybrid Homo sapiens
117 PLCG1 5335
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
118 ARHGEF28  
Biochemical Activity Homo sapiens
119 Foxo1  
Biochemical Activity Mus musculus
120 CUL1 8454
Affinity Capture-Western Homo sapiens
121 AKTIP  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
122 FGFR1 2260
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 GSK3B 2932
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
124 GDA 9615
Affinity Capture-MS Homo sapiens
125 PAK1 5058
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
126 CCT2 10576
Biochemical Activity Homo sapiens
127 CAMK2A 815
Affinity Capture-MS Homo sapiens
128 NKD1 85407
Biochemical Activity Homo sapiens
129 CTDP1 9150
Biochemical Activity Homo sapiens
130 CDKN1A  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
131 NCOR2  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
132 RNF115  
Biochemical Activity Homo sapiens
133 ACTA1 58
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
134 RPS6KB1 6198
Co-purification Homo sapiens
Co-localization Homo sapiens
135 KDM4B  
Affinity Capture-Western Homo sapiens
136 SLC9A1 6548
Affinity Capture-Western Homo sapiens
137 RLIM 51132
Affinity Capture-Western Homo sapiens
138 PPP2CA 5515
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
139 SLFN5 162394
Biochemical Activity Homo sapiens
140 CGGBP1 8545
Biochemical Activity Homo sapiens
141 PTPN11 5781
Reconstituted Complex Homo sapiens
142 TUBB 203068
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 USP4 7375
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
144 TBCE 6905
Biochemical Activity Homo sapiens
145 JADE1  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
146 CTTN 2017
Co-fractionation Homo sapiens
147 DAB2IP 153090
Biochemical Activity Homo sapiens
148 RICTOR 253260
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
149 GATSL3 652968
Biochemical Activity Homo sapiens
150 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
151 PTK2 5747
Co-localization Homo sapiens
152 MAP3K8  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
153 GAB1  
Biochemical Activity Homo sapiens
154 DUSP13  
Affinity Capture-MS Homo sapiens
155 PRKCQ 5588
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
156 C1orf174  
Biochemical Activity Homo sapiens
157 PPP2R1A 5518
Biochemical Activity Homo sapiens
158 FUS 2521
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
159 ZDHHC18 84243
Affinity Capture-MS Homo sapiens
160 CCDC88A 55704
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
161 ZRANB1 54764
Biochemical Activity Homo sapiens
162 FHL1 2273
Affinity Capture-Western Homo sapiens
163 MUL1  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
164 TRIM13  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
165 SMAD7  
Affinity Capture-Western Homo sapiens
166 SORBS1 10580
Biochemical Activity Homo sapiens
167 MAP2K4 6416
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
168 OXSR1 9943
Biochemical Activity Homo sapiens
169 SMAD4  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
170 TSC1 7248
Affinity Capture-Western Homo sapiens
171 DDIT4L  
Two-hybrid Homo sapiens
172 ESR1  
Biochemical Activity Homo sapiens
173 BCL2L1 598
Biochemical Activity Homo sapiens
174 REPS1 85021
Biochemical Activity Homo sapiens
175 ATP1A1 476
Affinity Capture-MS Homo sapiens
176 SLC9A3R1 9368
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
177 TRIB3  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
178 ATP6V0A2 23545
Affinity Capture-MS Homo sapiens
179 KAT6A  
Biochemical Activity Homo sapiens
180 RASD2  
Affinity Capture-Western Homo sapiens
181 NGB  
FRET Homo sapiens
Reconstituted Complex Homo sapiens
182 GATA1  
Biochemical Activity Homo sapiens
183 PPP3CA 5530
Affinity Capture-Western Homo sapiens
184 RGCC 28984
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
185 EEF1G 1937
Two-hybrid Homo sapiens
186 YWHAE 7531
Affinity Capture-MS Homo sapiens
187 GATA2  
Biochemical Activity Homo sapiens
188 EFTUD1 79631
Co-fractionation Homo sapiens
189 SSB 6741
Co-fractionation Homo sapiens
190 EGLN1 54583
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
191 PEBP1 5037
Affinity Capture-MS Homo sapiens
192 RPS6KB2  
Affinity Capture-MS Homo sapiens
193 FOXO4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
194 MOK  
Biochemical Activity Homo sapiens
195 PCGF2 7703
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
196 CAPZB 832
Affinity Capture-MS Homo sapiens
197 PLEKHO1 51177
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
198 WDR48 57599
Co-fractionation Homo sapiens
199 HEATR3 55027
Biochemical Activity Homo sapiens
200 PSRC1  
Biochemical Activity Homo sapiens
201 NFE2L2 4780
Affinity Capture-Western Homo sapiens
202 IQGAP1 8826
Affinity Capture-Western Homo sapiens
203 CDKN1C  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
204 PKN2 5586
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
205 APOH 350
Two-hybrid Homo sapiens
206 APPL1 26060
Co-localization Homo sapiens
207 HSPA8 3312
Affinity Capture-MS Homo sapiens
208 Cdkn1b  
Biochemical Activity Mus musculus
209 C19orf60  
Biochemical Activity Homo sapiens
210 NF2 4771
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
211 SPACA6P  
Biochemical Activity Homo sapiens
212 THEM4  
Affinity Capture-Western Homo sapiens
213 PSMB4 5692
Affinity Capture-MS Homo sapiens
214 IRAK1  
Affinity Capture-Western Homo sapiens
215 PARK2  
Affinity Capture-MS Homo sapiens
216 WDR53  
Biochemical Activity Homo sapiens
217 Sertad4  
Two-hybrid Mus musculus
218 USP8 9101
Affinity Capture-Western Homo sapiens
219 MAPT  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
220 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
221 SMAD2 4087
Affinity Capture-Western Homo sapiens
222 MB21D1  
Proximity Label-MS Homo sapiens
223 ACTB 60
Affinity Capture-MS Homo sapiens
224 PIK3R1 5295
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
225 EIF4EBP1  
Co-localization Homo sapiens
226 MLF2 8079
Biochemical Activity Homo sapiens
227 DNM1L 10059
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
228 NCOA4 8031
Two-hybrid Homo sapiens
229 EFHC1  
Biochemical Activity Homo sapiens
230 PA2G4 5036
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
231 PREX1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
232 ZHX1  
Two-hybrid Homo sapiens
233 NFKBIA  
Affinity Capture-Western Homo sapiens
234 SIRPA 140885
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
235 MAPKAPK2 9261
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
236 TRAF6 7189
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
237 PTEN 5728
Affinity Capture-Western Homo sapiens
238 CHFR  
Affinity Capture-Western Homo sapiens
239 GLI1  
Co-localization Homo sapiens
240 ARHGEF16 27237
Biochemical Activity Homo sapiens
241 METTL21B  
Affinity Capture-MS Homo sapiens
242 PDPK1 5170
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Co-localization Homo sapiens
243 SFMBT2  
Biochemical Activity Homo sapiens
244 GRB10 2887
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
245 OSBPL11 114885
Biochemical Activity Homo sapiens
246 UMPS 7372
Affinity Capture-MS Homo sapiens
247 MTOR 2475
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
248 PIAS1 8554
Two-hybrid Homo sapiens
249 PIK3CA 5290
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
250 USP50  
Biochemical Activity Homo sapiens
251 ENO2 2026
Affinity Capture-MS Homo sapiens
252 ZC3HAV1 56829
Biochemical Activity Homo sapiens
253 HSPA9 3313
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
254 CHUK 1147
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
255 NEDD4L 23327
Biochemical Activity Homo sapiens
256 PFKFB1  
Biochemical Activity Homo sapiens
257 AHSA1 10598
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
258 POP7  
Biochemical Activity Homo sapiens
259 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
260 PHB2 11331
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
261 FOXO3  
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
262 MAPKAP1 79109
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
263 SERTAD4  
Affinity Capture-Western Homo sapiens
264 TOPBP1 11073
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
265 URI1  
Biochemical Activity Homo sapiens
266 KAT2B  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
267 IKBKG 8517
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
268 POP4 10775
Biochemical Activity Homo sapiens
269 RPTOR 57521
Affinity Capture-Western Homo sapiens
270 HSPB1 3315
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
271 CREBBP  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
272 ZDHHC23  
Affinity Capture-MS Homo sapiens
273 GNB1 2782
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
274 DDX58 23586
Affinity Capture-RNA Homo sapiens
275 BPGM 669
Two-hybrid Homo sapiens
276 TCL1B  
Affinity Capture-Western Homo sapiens
277 NQO1 1728
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
278 LRRK2 120892
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
279 ACAP1 9744
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
280 AR 367
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
281 VIM 7431
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
282 NOTCH1 4851
Biochemical Activity Homo sapiens
283 EP300 2033
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
284 OTUD5 55593
Affinity Capture-Western Homo sapiens
285 XAF1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
286 XIAP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
287 TEK  
Co-localization Homo sapiens
288 CSK 1445
Co-fractionation Homo sapiens
289 TRAF4 9618
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
290 FAM110C  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
291 HIST1H2BB 3018
Biochemical Activity Homo sapiens
292 FAM168A  
Biochemical Activity Homo sapiens
293 PPIA 5478
Affinity Capture-MS Homo sapiens
294 CALM1 801
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
295 APP 351
Reconstituted Complex Homo sapiens
296 HSPA5 3309
Affinity Capture-MS Homo sapiens
297 GSK3A 2931
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
298 PPP1CC 5501
Affinity Capture-Western Homo sapiens
299 MARK2 2011
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
300 SSC4D  
Affinity Capture-MS Homo sapiens
301 Nedd4 25489
Biochemical Activity Rattus norvegicus
302 PCK1 5105
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
303 IMPDH2 3615
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
304 MDH1 4190
Affinity Capture-MS Homo sapiens
305 YWHAG 7532
Affinity Capture-MS Homo sapiens
306 TRIT1  
Biochemical Activity Homo sapiens
307 WNK4  
Biochemical Activity Homo sapiens
308 TERT  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
309 GABBR2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
310 MARK4  
Biochemical Activity Homo sapiens
311 MAPK4  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
312 SMARCB1 6598
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
313 NEDD4 4734
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
314 ARHGAP9 64333
Biochemical Activity Homo sapiens
315 TRIM15  
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
316 PDK1 5163
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
317 PPP1CA 5499
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
318 PLXNB1 5364
Affinity Capture-Western Homo sapiens
319 ERBB3 2065
Affinity Capture-Western Homo sapiens
320 RPE  
Co-fractionation Homo sapiens
321 PIK3CB 5291
Co-fractionation Homo sapiens
322 DDX5 1655
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
323 PIAS2  
Two-hybrid Homo sapiens
Co-localization Homo sapiens
324 CHEK1  
Negative Genetic Homo sapiens
325 DCTN1 1639
Two-hybrid Homo sapiens
326 PYCRL 65263
Biochemical Activity Homo sapiens
327 ITPKB  
Biochemical Activity Homo sapiens
328 BRAF  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
329 CEP76  
Two-hybrid Homo sapiens
330 MAGEB1  
Biochemical Activity Homo sapiens
331 AGAP2  
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
332 PRKAR1A 5573
Biochemical Activity Homo sapiens
333 SMARCC2 6601
Affinity Capture-Western Homo sapiens
334 MESDC2 23184
Two-hybrid Homo sapiens
335 RAP1GDS1 5910
Biochemical Activity Homo sapiens
336 NR4A1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
337 TCL1A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
338 AMBRA1  
Biochemical Activity Homo sapiens
339 NOS3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
340 RNF14 9604
Affinity Capture-MS Homo sapiens
341 CTNNB1 1499
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
342 TTC3 7267
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
343 MXD1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
344 GPT2  
Biochemical Activity Homo sapiens
345 BAP1 8314
Affinity Capture-Western Homo sapiens
346 FKBP5 2289
Affinity Capture-Western Homo sapiens
347 AKT1S1 84335
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
348 AKT2 208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
349 SIRT2 22933
Affinity Capture-Western Homo sapiens
350 HK1 3098
Affinity Capture-MS Homo sapiens
351 CLTC 1213
Affinity Capture-MS Homo sapiens
352 PDE3A  
Biochemical Activity Homo sapiens
353 IRF3 3661
Affinity Capture-Western Homo sapiens
354 SNCA 6622
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
355 TNK2 10188
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
356 ARRB2 409
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
357 SIRT6  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
358 SNAI1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
359 PPM1H  
Biochemical Activity Homo sapiens
360 SMARCC1 6599
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
361 IKBKB 3551
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
362 MTCP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
363 PDE3B  
Affinity Capture-MS Homo sapiens
364 CREB1  
Biochemical Activity Homo sapiens
365 TMEM126B 55863
Affinity Capture-Western Homo sapiens
366 EZH2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
367 RNF20 56254
Co-fractionation Homo sapiens
368 MAPK9 5601
Biochemical Activity Homo sapiens
369 IBTK 25998
Affinity Capture-Western Homo sapiens
370 PINK1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
371 MAP3K11 4296
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
372 ZFP36L1  
Biochemical Activity Homo sapiens
373 Rpl23 65019
Two-hybrid Mus musculus
374 BAD  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
375 IRS1 3667
Affinity Capture-Western Homo sapiens
376 ALDOA 226
Affinity Capture-MS Homo sapiens
377 CLIP3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which AKT1 is involved
PathwayEvidenceSource
Activation of BAD and translocation to mitochondria IEA Reactome
Activation of BH3-only proteins IEA Reactome
Adaptive Immune System TAS Reactome
AKT phosphorylates targets in the cytosol TAS Reactome
AKT phosphorylates targets in the cytosol IEA Reactome
AKT phosphorylates targets in the nucleus TAS Reactome
AKT-mediated inactivation of FOXO1A TAS Reactome
Apoptosis IEA Reactome
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA TAS Reactome
CD28 co-stimulation TAS Reactome
CD28 dependent PI3K/Akt signaling TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular response to chemical stress TAS Reactome
Cellular responses to mechanical stimuli TAS Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress TAS Reactome
Constitutive Signaling by AKT1 E17K in Cancer TAS Reactome
Costimulation by the CD28 family TAS Reactome
CTLA4 inhibitory signaling TAS Reactome
Cyclin A:Cdk2-associated events at S phase entry TAS Reactome
Cyclin E associated events during G1/S transition TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Deactivation of the beta-catenin transactivating complex TAS Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downregulation of ERBB2 signaling TAS Reactome
Downregulation of ERBB2:ERBB3 signaling TAS Reactome
eNOS activation TAS Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent nuclear events downstream of ESR-membrane signaling TAS Reactome
Extra-nuclear estrogen signaling TAS Reactome
FLT3 Signaling TAS Reactome
FOXO-mediated transcription TAS Reactome
G beta:gamma signalling through PI3Kgamma TAS Reactome
G-protein beta:gamma signalling TAS Reactome
G1/S Transition TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
GPCR downstream signalling TAS Reactome
Hemostasis TAS Reactome
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells TAS Reactome
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells IEA Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Integrin signaling TAS Reactome
Interleukin-4 and Interleukin-13 signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Intrinsic Pathway for Apoptosis IEA Reactome
KEAP1-NFE2L2 pathway TAS Reactome
KSRP (KHSRP) binds and destabilizes mRNA TAS Reactome
Membrane Trafficking TAS Reactome
Membrane Trafficking IEA Reactome
Metabolism TAS Reactome
Metabolism of cofactors TAS Reactome
Metabolism of nitric oxide: NOS3 activation and regulation TAS Reactome
Metabolism of RNA TAS Reactome
Metabolism of vitamins and cofactors TAS Reactome
Mitochondrial unfolded protein response (UPRmt) TAS Reactome
Mitotic G1 phase and G1/S transition TAS Reactome
MTOR signalling TAS Reactome
Negative regulation of NOTCH4 signaling TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
PIP3 activates AKT signaling IEA Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Aggregation (Plug Formation) TAS Reactome
Programmed Cell Death IEA Reactome
PTEN Regulation TAS Reactome
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 TAS Reactome
RAB GEFs exchange GTP for GDP on RABs TAS Reactome
Rab regulation of trafficking TAS Reactome
Regulation of beta-cell development TAS Reactome
Regulation of gene expression in beta cells TAS Reactome
Regulation of localization of FOXO transcription factors TAS Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements TAS Reactome
Regulation of PTEN stability and activity TAS Reactome
Regulation of TP53 Activity TAS Reactome
Regulation of TP53 Activity through Acetylation TAS Reactome
Regulation of TP53 Activity through Association with Co-factors TAS Reactome
Regulation of TP53 Degradation TAS Reactome
Regulation of TP53 Expression and Degradation TAS Reactome
Response of endothelial cells to shear stress TAS Reactome
Response of endothelial cells to shear stress IEA Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX2 regulates genes involved in cell migration IEA Reactome
S Phase TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2 targets host intracellular signalling and regulatory pathways TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ERBB2 TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by Non-Receptor Tyrosine Kinases TAS Reactome
Signaling by NOTCH TAS Reactome
Signaling by NOTCH4 TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by PTK6 TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by VEGF TAS Reactome
Signaling by WNT TAS Reactome
TCF dependent signaling in response to WNT TAS Reactome
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation TAS Reactome
TP53 Regulates Metabolic Genes TAS Reactome
Transcriptional regulation by RUNX2 IEA Reactome
Transcriptional Regulation by TP53 TAS Reactome
Translocation of SLC2A4 (GLUT4) to the plasma membrane IEA Reactome
VEGFA-VEGFR2 Pathway TAS Reactome
VEGFR2 mediated vascular permeability TAS Reactome
Vesicle-mediated transport TAS Reactome
Vesicle-mediated transport IEA Reactome
Viral Infection Pathways TAS Reactome





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