Gene description for CAMKK2
Gene name calcium/calmodulin-dependent protein kinase kinase 2, beta
Gene symbol CAMKK2
Other names/aliases CAMKK
Species Homo sapiens
 Database cross references - CAMKK2
ExoCarta ExoCarta_10645
Entrez Gene 10645
HGNC 1470
MIM 615002
UniProt Q96RR4  
 CAMKK2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CAMKK2
Molecular Function
    protein tyrosine kinase activity GO:0004713 TAS
    calcium ion binding GO:0005509 IDA
    calmodulin binding GO:0005516 TAS
    calmodulin-dependent protein kinase activity GO:0004683 IEA
    ATP binding GO:0005524 IEA
Biological Process
    protein phosphorylation GO:0006468 IDA
    regulation of protein kinase activity GO:0045859 TAS
    peptidyl-tyrosine phosphorylation GO:0018108 TAS
    MAPK cascade GO:0000165 TAS
    calcium-mediated signaling GO:0019722 TAS
    positive regulation of transcription, DNA-templated GO:0045893 TAS
    protein autophosphorylation GO:0046777 IDA
Subcellular Localization
    nucleus GO:0005634 IEA
    intracellular GO:0005622 TAS
    cytoplasm GO:0005737 IDA
    cell projection GO:0042995 IEA
 Experiment description of studies that identified CAMKK2 in exosomes
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CAMKK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SGK1  
Affinity Capture-Western Homo sapiens
2 PRKACA 5566
Biochemical Activity Homo sapiens
3 CAMK1  
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which CAMKK2 is involved
No pathways found

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