Gene description for EBAG9
Gene name estrogen receptor binding site associated, antigen, 9
Gene symbol EBAG9
Other names/aliases EB9
PDAF
Species Homo sapiens
 Database cross references - EBAG9
ExoCarta ExoCarta_9166
Vesiclepedia VP_9166
Entrez Gene 9166
HGNC 3123
MIM 605772
UniProt O00559  
 EBAG9 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for EBAG9
Molecular Function
    protein binding GO:0005515 IPI
    peptidase activator activity involved in apoptotic process GO:0016505 NAS
Biological Process
    regulation of cell growth GO:0001558 NAS
    T cell mediated cytotoxicity GO:0001913 IEA
    apoptotic process GO:0006915 IEA
    adaptive immune memory response involving T cells and B cells GO:0090717 IEA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    secretory granule GO:0030141 IBA
 Experiment description of studies that identified EBAG9 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for EBAG9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Proximity Label-MS Homo sapiens
2 ITGB1 3688
Proximity Label-MS Homo sapiens
3 ATP6V1B2 526
Proximity Label-MS Homo sapiens
4 COPG2 26958
Proximity Label-MS Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 TRAPPC8 22878
Proximity Label-MS Homo sapiens
7 ARHGAP1 392
Proximity Label-MS Homo sapiens
8 MON2 23041
Proximity Label-MS Homo sapiens
9 AP2B1 163
Proximity Label-MS Homo sapiens
10 SLC30A6 55676
Proximity Label-MS Homo sapiens
11 ZDHHC5 25921
Proximity Label-MS Homo sapiens
12 SLC35A1 10559
Two-hybrid Homo sapiens
13 SLC7A5 8140
Proximity Label-MS Homo sapiens
14 OCLN 100506658
Proximity Label-MS Homo sapiens
15 SNAP23 8773
Proximity Label-MS Homo sapiens
16 SEC16A 9919
Proximity Label-MS Homo sapiens
17 VAPA 9218
Two-hybrid Homo sapiens
18 METTL7A 25840
Proximity Label-MS Homo sapiens
19 LAMP3  
Proximity Label-MS Homo sapiens
20 GJA1 2697
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
21 EFR3A 23167
Proximity Label-MS Homo sapiens
22 PARD3 56288
Proximity Label-MS Homo sapiens
23 ARFGAP2 84364
Proximity Label-MS Homo sapiens
24 JPH1 56704
Proximity Label-MS Homo sapiens
25 DNAJA1 3301
Proximity Label-MS Homo sapiens
26 EPB41L5 57669
Proximity Label-MS Homo sapiens
27 SLC35B4  
Two-hybrid Homo sapiens
28 ARFGAP3 26286
Proximity Label-MS Homo sapiens
29 SURF4 6836
Proximity Label-MS Homo sapiens
30 COPB2 9276
Proximity Label-MS Homo sapiens
31 ADD3 120
Proximity Label-MS Homo sapiens
32 MAP4K4 9448
Proximity Label-MS Homo sapiens
33 ARCN1 372
Proximity Label-MS Homo sapiens
34 GOSR2 9570
Proximity Label-MS Homo sapiens
35 COG2 22796
Proximity Label-MS Homo sapiens
36 DDHD2 23259
Proximity Label-MS Homo sapiens
37 APBB1  
Proximity Label-MS Homo sapiens
38 COPA 1314
Proximity Label-MS Homo sapiens
39 SNX6 58533
Proximity Label-MS Homo sapiens
40 SLC12A2 6558
Proximity Label-MS Homo sapiens
41 MTMR9 66036
Proximity Label-MS Homo sapiens
42 PI4KA 5297
Proximity Label-MS Homo sapiens
43 WDR6 11180
Proximity Label-MS Homo sapiens
44 KIAA1033 23325
Proximity Label-MS Homo sapiens
45 APEX1 328
Affinity Capture-RNA Homo sapiens
46 VANGL2  
Proximity Label-MS Homo sapiens
47 EPB41L3 23136
Proximity Label-MS Homo sapiens
48 B3GAT1  
Proximity Label-MS Homo sapiens
49 CLEC4G  
Two-hybrid Homo sapiens
50 STX1A 6804
Two-hybrid Homo sapiens
51 WDR41  
Proximity Label-MS Homo sapiens
52 USO1 8615
Proximity Label-MS Homo sapiens
53 PAK4 10298
Proximity Label-MS Homo sapiens
54 FAM171A2 284069
Proximity Label-MS Homo sapiens
55 APBB2  
Proximity Label-MS Homo sapiens
56 GOLGA3 2802
Proximity Label-MS Homo sapiens
57 AP2A1 160
Proximity Label-MS Homo sapiens
58 CXADR 1525
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
59 HGS 9146
Proximity Label-MS Homo sapiens
60 DIAPH3 81624
Proximity Label-MS Homo sapiens
61 UNC5B 219699
Proximity Label-MS Homo sapiens
62 COL4A3BP 10087
Proximity Label-MS Homo sapiens
63 CPD 1362
Proximity Label-MS Homo sapiens
64 DSC2 1824
Proximity Label-MS Homo sapiens
65 CUX1 1523
Proximity Label-MS Homo sapiens
66 CFHR5  
Two-hybrid Homo sapiens
67 MAP4K5 11183
Proximity Label-MS Homo sapiens
68 ADD1 118
Proximity Label-MS Homo sapiens
69 SSR1 6745
Proximity Label-MS Homo sapiens
70 RASAL2 9462
Proximity Label-MS Homo sapiens
71 GAK 2580
Proximity Label-MS Homo sapiens
72 STEAP3 55240
Proximity Label-MS Homo sapiens
73 USP33  
Proximity Label-MS Homo sapiens
74 HSPA12A 259217
Proximity Label-MS Homo sapiens
75 ACSL5 51703
Two-hybrid Homo sapiens
76 GOPC 57120
Proximity Label-MS Homo sapiens
77 SLC30A5 64924
Proximity Label-MS Homo sapiens
78 ZC3HAV1 56829
Proximity Label-MS Homo sapiens
79 PTPN14 5784
Proximity Label-MS Homo sapiens
80 RAB11FIP1 80223
Proximity Label-MS Homo sapiens
81 GOLGA4  
Proximity Label-MS Homo sapiens
82 VPS53 55275
Proximity Label-MS Homo sapiens
83 SEC23A 10484
Proximity Label-MS Homo sapiens
84 RAB12 201475
Proximity Label-MS Homo sapiens
85 TMEM107 84314
Two-hybrid Homo sapiens
86 ESYT2 57488
Proximity Label-MS Homo sapiens
87 C14orf180  
Two-hybrid Homo sapiens
88 SLC6A15 55117
Proximity Label-MS Homo sapiens
89 DSG2 1829
Proximity Label-MS Homo sapiens
90 NEDD4 4734
Reconstituted Complex Homo sapiens
91 TFRC 7037
Proximity Label-MS Homo sapiens
92 TMEM87A 25963
Proximity Label-MS Homo sapiens
93 EXOC3 11336
Proximity Label-MS Homo sapiens
94 IFT20 90410
Proximity Label-MS Homo sapiens
95 NOTCH2 4853
Proximity Label-MS Homo sapiens
96 CASK 8573
Proximity Label-MS Homo sapiens
97 PLEKHA1 59338
Proximity Label-MS Homo sapiens
98 NUP155 9631
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
99 SLC30A1 7779
Proximity Label-MS Homo sapiens
100 SNAP47 116841
Proximity Label-MS Homo sapiens
101 FAM96A  
Two-hybrid Homo sapiens
102 IRS4 8471
Proximity Label-MS Homo sapiens
103 SCFD1 23256
Proximity Label-MS Homo sapiens
104 EFNB2 1948
Proximity Label-MS Homo sapiens
105 SMPD4 55627
Proximity Label-MS Homo sapiens
106 SCYL1 57410
Proximity Label-MS Homo sapiens
107 EMD 2010
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
108 TMEM115 11070
Proximity Label-MS Homo sapiens
109 LNPEP 4012
Proximity Label-MS Homo sapiens
110 VPS51 738
Proximity Label-MS Homo sapiens
111 COPE 11316
Proximity Label-MS Homo sapiens
112 STOM 2040
Proximity Label-MS Homo sapiens
113 TMEM165 55858
Proximity Label-MS Homo sapiens
114 COPG1 22820
Proximity Label-MS Homo sapiens
115 BET1L 51272
Proximity Label-MS Homo sapiens
116 SPTAN1 6709
Proximity Label-MS Homo sapiens
117 EXOC4 60412
Proximity Label-MS Homo sapiens
118 GOLGA2 2801
Proximity Label-MS Homo sapiens
119 COPB1 1315
Proximity Label-MS Homo sapiens
120 GORAB 92344
Proximity Label-MS Homo sapiens
121 VRK2 7444
Proximity Label-MS Homo sapiens
122 PDXDC1 23042
Proximity Label-MS Homo sapiens
123 GCC2 9648
Proximity Label-MS Homo sapiens
124 TBC1D22B  
Proximity Label-MS Homo sapiens
125 TRAPPC12 51112
Proximity Label-MS Homo sapiens
126 APOL2 23780
Two-hybrid Homo sapiens
127 NUMB 8650
Proximity Label-MS Homo sapiens
128 TPRG1  
Two-hybrid Homo sapiens
129 SPRY4 81848
Proximity Label-MS Homo sapiens
130 GORASP2 26003
Proximity Label-MS Homo sapiens
131 FAM135A  
Proximity Label-MS Homo sapiens
132 PI4KB 5298
Proximity Label-MS Homo sapiens
133 AP1B1 162
Proximity Label-MS Homo sapiens
134 PEAK1 79834
Proximity Label-MS Homo sapiens
135 LRBA 987
Proximity Label-MS Homo sapiens
136 COG3 83548
Proximity Label-MS Homo sapiens
137 RAB3GAP1 22930
Proximity Label-MS Homo sapiens
138 PIK3R1 5295
Proximity Label-MS Homo sapiens
139 SCOC 60592
Proximity Label-MS Homo sapiens
140 STX5 6811
Proximity Label-MS Homo sapiens
141 GCC1 79571
Proximity Label-MS Homo sapiens
142 RAB11FIP5 26056
Proximity Label-MS Homo sapiens
143 MPP7 143098
Proximity Label-MS Homo sapiens
144 COG5 10466
Proximity Label-MS Homo sapiens
145 FLOT2 2319
Proximity Label-MS Homo sapiens
146 GOLGB1 2804
Proximity Label-MS Homo sapiens
147 COG4 25839
Proximity Label-MS Homo sapiens
148 IFNGR1 3459
Proximity Label-MS Homo sapiens
149 VPS45 11311
Proximity Label-MS Homo sapiens
150 ACBD3 64746
Proximity Label-MS Homo sapiens
151 CLN6  
Two-hybrid Homo sapiens
152 SLC4A7 9497
Proximity Label-MS Homo sapiens
153 TMF1 7110
Proximity Label-MS Homo sapiens
154 DST 667
Proximity Label-MS Homo sapiens
155 OR10AG1  
Two-hybrid Homo sapiens
156 ACTN1 87
Proximity Label-MS Homo sapiens
157 PALM2  
Proximity Label-MS Homo sapiens
158 SMCR8 140775
Proximity Label-MS Homo sapiens
159 FAM83B  
Proximity Label-MS Homo sapiens
160 SLC30A2  
Two-hybrid Homo sapiens
161 VAPB 9217
Two-hybrid Homo sapiens
162 NEO1 4756
Proximity Label-MS Homo sapiens
163 PTPN13 5783
Proximity Label-MS Homo sapiens
164 CDCA3 83461
Proximity Label-MS Homo sapiens
165 ATP2B1 490
Proximity Label-MS Homo sapiens
166 ROBO1 6091
Proximity Label-MS Homo sapiens
167 ERBB2IP 55914
Proximity Label-MS Homo sapiens
168 RGP1 9827
Proximity Label-MS Homo sapiens
169 ARFGEF1 10565
Proximity Label-MS Homo sapiens
170 DLG1 1739
Proximity Label-MS Homo sapiens
171 FAM171A1 221061
Proximity Label-MS Homo sapiens
172 HSD3B7 80270
Proximity Label-MS Homo sapiens
173 PPP1R37 284352
Proximity Label-MS Homo sapiens
174 DMXL1 1657
Proximity Label-MS Homo sapiens
175 WDR11 55717
Proximity Label-MS Homo sapiens
176 LAMP2 3920
Proximity Label-MS Homo sapiens
177 VAMP3 9341
Proximity Label-MS Homo sapiens
178 HOOK3 84376
Proximity Label-MS Homo sapiens
179 GBF1 8729
Proximity Label-MS Homo sapiens
180 VAMP2 6844
Proximity Label-MS Homo sapiens
181 TFG 10342
Proximity Label-MS Homo sapiens
182 ARFIP1 27236
Proximity Label-MS Homo sapiens
183 ORMDL1 94101
Two-hybrid Homo sapiens
184 COG1 9382
Proximity Label-MS Homo sapiens
185 RIC1 57589
Proximity Label-MS Homo sapiens
186 PCDH7 5099
Proximity Label-MS Homo sapiens
187 CDC42BPA 8476
Proximity Label-MS Homo sapiens
188 KIRREL 55243
Proximity Label-MS Homo sapiens
189 RPS27L 51065
Proximity Label-MS Homo sapiens
190 TRAPPC11 60684
Proximity Label-MS Homo sapiens
191 MRPS11  
Proximity Label-MS Homo sapiens
192 SLC35A4  
Two-hybrid Homo sapiens
193 SEC31A 22872
Proximity Label-MS Homo sapiens
194 SLC3A2 6520
Proximity Label-MS Homo sapiens
195 PKP4 8502
Proximity Label-MS Homo sapiens
196 TACC1 6867
Proximity Label-MS Homo sapiens
197 RAB9A 9367
Proximity Label-MS Homo sapiens
198 AP2A2 161
Proximity Label-MS Homo sapiens
199 SMAP2 64744
Proximity Label-MS Homo sapiens
200 TJAP1 93643
Proximity Label-MS Homo sapiens
201 NCLN 56926
Proximity Label-MS Homo sapiens
202 PPFIBP1 8496
Proximity Label-MS Homo sapiens
203 SIRT2 22933
Proximity Label-MS Homo sapiens
204 TMEM2 23670
Proximity Label-MS Homo sapiens
205 BNIP3 664
Two-hybrid Homo sapiens
206 KIDINS220 57498
Proximity Label-MS Homo sapiens
207 HLA-A 3105
Proximity Label-MS Homo sapiens
208 CPNE8 144402
Proximity Label-MS Homo sapiens
209 FAM114A2  
Proximity Label-MS Homo sapiens
210 REEP6  
Two-hybrid Homo sapiens
211 EHBP1 23301
Proximity Label-MS Homo sapiens
212 OCRL 4952
Proximity Label-MS Homo sapiens
213 STX2 2054
Two-hybrid Homo sapiens
214 SEC24B 10427
Proximity Label-MS Homo sapiens
215 DENND4C 55667
Proximity Label-MS Homo sapiens
216 MARK3 4140
Proximity Label-MS Homo sapiens
217 DEPDC1B 55789
Proximity Label-MS Homo sapiens
218 GGA3 23163
Proximity Label-MS Homo sapiens
219 PVRL2 5819
Proximity Label-MS Homo sapiens
220 PEX16 9409
Two-hybrid Homo sapiens
221 SLC38A2 54407
Proximity Label-MS Homo sapiens
222 BSDC1 55108
Proximity Label-MS Homo sapiens
223 PLEKHA5 54477
Proximity Label-MS Homo sapiens
224 ARFGEF2 10564
Proximity Label-MS Homo sapiens
225 RAB3GAP2 25782
Proximity Label-MS Homo sapiens
226 JUP 3728
Proximity Label-MS Homo sapiens
227 SEC23IP 11196
Proximity Label-MS Homo sapiens
228 SCYL3 57147
Proximity Label-MS Homo sapiens
229 SCYL2 55681
Proximity Label-MS Homo sapiens
230 SYAP1 94056
Proximity Label-MS Homo sapiens
231 VPS13B  
Proximity Label-MS Homo sapiens
232 MARK2 2011
Proximity Label-MS Homo sapiens
233 PPFIA1 8500
Proximity Label-MS Homo sapiens
234 GOSR1 9527
Proximity Label-MS Homo sapiens
235 FAM171B  
Proximity Label-MS Homo sapiens
236 LSR 51599
Proximity Label-MS Homo sapiens
237 SEC23B 10483
Proximity Label-MS Homo sapiens
238 XPR1 9213
Proximity Label-MS Homo sapiens
239 CLPTM1 1209
Proximity Label-MS Homo sapiens
240 UBA52 7311
Proximity Label-MS Homo sapiens
241 NDC1 55706
Proximity Label-MS Homo sapiens
242 VAMP4 8674
Proximity Label-MS Homo sapiens
243 TPD52L2 7165
Proximity Label-MS Homo sapiens
244 GOLPH3 64083
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
245 SCAMP3 10067
Proximity Label-MS Homo sapiens
246 EPN2 22905
Proximity Label-MS Homo sapiens
247 EPB41L2 2037
Proximity Label-MS Homo sapiens
248 TRIP11 9321
Proximity Label-MS Homo sapiens
249 ANKRD26 22852
Proximity Label-MS Homo sapiens
250 LMAN1 3998
Proximity Label-MS Homo sapiens
251 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
252 ROR2 4920
Proximity Label-MS Homo sapiens
253 SEC24A 10802
Proximity Label-MS Homo sapiens
254 RABL3 285282
Proximity Label-MS Homo sapiens
255 ERGIC2 51290
Proximity Label-MS Homo sapiens
256 GOLPH3L 55204
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
257 PLD3 23646
Proximity Label-MS Homo sapiens
258 SCRIB 23513
Proximity Label-MS Homo sapiens
259 PHACTR4 65979
Proximity Label-MS Homo sapiens
260 SEC62 7095
Proximity Label-MS Homo sapiens
261 GOLGA5 9950
Proximity Label-MS Homo sapiens
262 STX3 6809
Two-hybrid Homo sapiens
263 SLC33A1 9197
Proximity Label-MS Homo sapiens
264 FRS2 10818
Proximity Label-MS Homo sapiens
265 SLC38A1 81539
Proximity Label-MS Homo sapiens
266 SLC6A8 6535