Gene description for SCN5A
Gene name	sodium channel, voltage gated, type V alpha subunit
Gene symbol	SCN5A
Other names/aliases	CDCD2 CMD1E CMPD2 HB1 HB2 HBBD HH1 ICCD IVF LQT3 Nav1.5 PFHB1 SSS1 VF1
Species	Homo sapiens
Database cross references - SCN5A
ExoCarta	ExoCarta_6331
Entrez Gene	6331
HGNC	10593
MIM	600163
UniProt	Q14524
SCN5A identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for SCN5A

Molecular Function     ubiquitin protein ligase binding GO:0031625 IPI     ion channel binding GO:0044325 IPI     ankyrin binding GO:0030506 IDA     voltage-gated sodium channel activity involved in AV node cell action potential GO:0086060 IMP     voltage-gated sodium channel activity involved in SA node cell action potential GO:0086063 IMP     fibroblast growth factor binding GO:0017134 IPI     protein kinase binding GO:0019901 IPI     calmodulin binding GO:0005516 IPI     scaffold protein binding GO:0097110 IPI     enzyme binding GO:0019899 IPI     voltage-gated sodium channel activity involved in bundle of His cell action potential GO:0086061 IMP     voltage-gated sodium channel activity GO:0005248 IDA     nitric-oxide synthase binding GO:0050998 IPI     voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 IMP     protein binding GO:0005515 IPI     voltage-gated sodium channel activity involved in Purkinje myocyte action potential GO:0086062 IMP Biological Process     ventricular cardiac muscle cell action potential GO:0086005 IMP     positive regulation of sodium ion transport GO:0010765 IDA     positive regulation of epithelial cell proliferation GO:0050679 ISS     regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 IMP     AV node cell to bundle of His cell communication GO:0086067 IMP     regulation of cardiac muscle cell contraction GO:0086004 IMP     sodium ion transmembrane transport GO:0035725 IMP     regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 IMP     neuronal action potential GO:0019228 IBA     cardiac ventricle development GO:0003231 ISS     membrane depolarization during action potential GO:0086010 IDA     brainstem development GO:0003360 ISS     cerebellum development GO:0021549 ISS     cardiac muscle contraction GO:0060048 IMP     membrane depolarization during Purkinje myocyte cell action potential GO:0086047 IMP     cellular response to calcium ion GO:0071277 IDA     axon guidance GO:0007411 TAS     regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 IMP     membrane depolarization during SA node cell action potential GO:0086046 ISS     membrane depolarization GO:0051899 IDA     regulation of sodium ion transmembrane transport GO:1902305 IDA     membrane depolarization during cardiac muscle cell action potential GO:0086012 IMP     SA node cell action potential GO:0086015 IMP     telencephalon development GO:0021537 ISS     odontogenesis of dentin-containing tooth GO:0042475 ISS     AV node cell action potential GO:0086016 IMP     positive regulation of action potential GO:0045760 ISS     sodium ion transport GO:0006814 IDA     cardiac muscle cell action potential involved in contraction GO:0086002 IMP     membrane depolarization during bundle of His cell action potential GO:0086048 IMP     regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 IMP     response to denervation involved in regulation of muscle adaptation GO:0014894 ISS     membrane depolarization during AV node cell action potential GO:0086045 IMP     bundle of His cell action potential GO:0086043 IMP     regulation of heart rate GO:0002027 IMP     regulation of heart rate by cardiac conduction GO:0086091 IMP Subcellular Localization     endoplasmic reticulum GO:0005783 IDA     sarcolemma GO:0042383 IDA     integral component of membrane GO:0016021 IDA     T-tubule GO:0030315 IDA     voltage-gated sodium channel complex GO:0001518 IDA     lateral plasma membrane GO:0016328 TAS     cell surface GO:0009986 IDA     intercalated disc GO:0014704 ISS     caveola GO:0005901 TAS     plasma membrane GO:0005886 IDA