Gene description for PRKX
Gene name protein kinase, X-linked
Gene symbol PRKX
Other names/aliases PKX1
Species Homo sapiens
 Database cross references - PRKX
ExoCarta ExoCarta_5613
Entrez Gene 5613
HGNC 9441
MIM 300083
UniProt P51817  
 PRKX identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for PRKX
Molecular Function
    cAMP-dependent protein kinase activity GO:0004691 IDA
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
Biological Process
    endothelial cell migration GO:0043542 IMP
    regulation of epithelial cell differentiation involved in kidney development GO:2000696 IDA
    protein autophosphorylation GO:0046777 IDA
    peptidyl-serine phosphorylation GO:0018105 IDA
    cell-substrate adhesion GO:0031589 IMP
    myeloid cell differentiation GO:0030099 IDA
    endothelial cell proliferation GO:0001935 IMP
    angiogenesis GO:0001525 IMP
    epithelial tube morphogenesis GO:0060562 IDA
    regulation of cell migration GO:0030334 IDA
    cell adhesion GO:0007155 IMP
    kidney morphogenesis GO:0060993 IDA
    regulation of cell adhesion GO:0030155 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified PRKX in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PRKX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRKAR1A 5573
Invivo Homo sapiens
Invitro Homo sapiens
2 PRKAR2A 5576
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which PRKX is involved
No pathways found

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