Gene description for FKBP15
Gene name FK506 binding protein 15, 133kDa
Gene symbol FKBP15
Other names/aliases FKBP133
KIAA0674
PPP1R76
Species Homo sapiens
 Database cross references - FKBP15
ExoCarta ExoCarta_23307
Vesiclepedia VP_23307
Entrez Gene 23307
HGNC 23397
UniProt Q5T1M5  
 FKBP15 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FKBP15
Molecular Function
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IEA
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
Biological Process
    endocytosis GO:0006897 IEA
Subcellular Localization
    early endosome GO:0005769 IEA
    actin cytoskeleton GO:0015629 IEA
    membrane GO:0016020 HDA
    membrane GO:0016020 IDA
    growth cone GO:0030426 IBA
 Experiment description of studies that identified FKBP15 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FKBP15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COMMD10 51397
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ATG16L1 55054
Affinity Capture-MS Homo sapiens
3 TMEM173  
Affinity Capture-MS Homo sapiens
4 VPS35 55737
Affinity Capture-MS Homo sapiens
5 MECP2 4204
Affinity Capture-MS Homo sapiens
6 SSFA2 6744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 AP2B1 163
Proximity Label-MS Homo sapiens
8 RHOU 58480
Reconstituted Complex Homo sapiens
9 MFAP4 4239
Affinity Capture-MS Homo sapiens
10 LGR4 55366
Affinity Capture-MS Homo sapiens
11 AMOT  
Proximity Label-MS Homo sapiens
12 ATP6V0D2 245972
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CST5 1473
Affinity Capture-MS Homo sapiens
14 NUDT12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 AIPL1  
Affinity Capture-MS Homo sapiens
16 KIAA0196 9897
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
17 RAB9A 9367
Proximity Label-MS Homo sapiens
18 XPO1 7514
Affinity Capture-MS Homo sapiens
19 BAG2 9532
Affinity Capture-MS Homo sapiens
20 WWOX 51741
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ZYX 7791
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SP1  
Affinity Capture-MS Homo sapiens
23 NUP62 23636
Affinity Capture-MS Homo sapiens
24 RPA1 6117
Affinity Capture-MS Homo sapiens
25 NUP62CL  
Affinity Capture-MS Homo sapiens
26 FOXC1  
Affinity Capture-MS Homo sapiens
27 CDK19 23097
Co-fractionation Homo sapiens
28 STRN3 29966
Proximity Label-MS Homo sapiens
29 POC1A  
Affinity Capture-MS Homo sapiens
30 FAM21A 387680
Affinity Capture-MS Homo sapiens
31 ZFYVE16  
Proximity Label-MS Homo sapiens
32 HSPA8 3312
Affinity Capture-MS Homo sapiens
33 EXOC1 55763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 NEDD4 4734
Co-fractionation Homo sapiens
35 Wash  
Affinity Capture-MS Mus musculus
36 CLTA 1211
Proximity Label-MS Homo sapiens
37 STX11 8676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 VPS29 51699
Affinity Capture-MS Homo sapiens
39 AP3B1 8546
Co-fractionation Homo sapiens
40 TTBK2 146057
Affinity Capture-MS Homo sapiens
41 DVL2 1856
Affinity Capture-MS Homo sapiens
42 VPS26A 9559
Affinity Capture-MS Homo sapiens
43 CAPZB 832
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
44 HSPA2 3306
Affinity Capture-MS Homo sapiens
45 MIOS 54468
Affinity Capture-MS Homo sapiens
46 C1orf87  
Affinity Capture-MS Homo sapiens
47 RPA3 6119
Affinity Capture-MS Homo sapiens
48 VCP 7415
Affinity Capture-MS Homo sapiens
49 MCM2 4171
Affinity Capture-MS Homo sapiens
50 RAB7A 7879
Proximity Label-MS Homo sapiens
51 ACTR3 10096
Proximity Label-MS Homo sapiens
52 CUL4A 8451
Affinity Capture-MS Homo sapiens
53 SERPINB2 5055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 FAM21C 253725
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
55 ZUFSP 221302
Affinity Capture-MS Homo sapiens
56 PRPF4 9128
Affinity Capture-MS Homo sapiens
57 UBC 7316
Affinity Capture-MS Homo sapiens
58 MDP1 145553
Affinity Capture-MS Homo sapiens
59 CCDC53 51019
Affinity Capture-MS Homo sapiens
60 CCBE1 147372
Affinity Capture-MS Homo sapiens
61 CTR9 9646
Affinity Capture-MS Homo sapiens
62 RPA2 6118
Affinity Capture-MS Homo sapiens
63 VPS26B 112936
Affinity Capture-MS Homo sapiens
64 KIAA1033 23325
Affinity Capture-MS Homo sapiens
65 LURAP1  
Affinity Capture-MS Homo sapiens
66 FGFR1OP  
Affinity Capture-MS Homo sapiens
67 PDE5A 8654
Affinity Capture-MS Homo sapiens
68 DNAJC13 23317
Affinity Capture-MS Homo sapiens
69 SNAP29 9342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FKBP15 is involved
No pathways found





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