Gene description for FGFR3
Gene name	fibroblast growth factor receptor 3
Gene symbol	FGFR3
Other names/aliases	ACH CD333 CEK2 HSFGFR3EX JTK4
Species	Homo sapiens
Database cross references - FGFR3
ExoCarta	ExoCarta_2261
Vesiclepedia	VP_2261
Entrez Gene	2261
HGNC	3690
MIM	134934
UniProt	P22607
FGFR3 identified in sEVs derived from the following tissue/cell type
Hepatocytes	26054723
Neuroblastoma cells	25944692
Squamous carcinoma cells	20124223
Urine	25452312

Gene ontology annotations for FGFR3

Molecular Function     protein tyrosine kinase activity GO:0004713 IDA     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IEA     fibroblast growth factor receptor activity GO:0005007 IBA     fibroblast growth factor receptor activity GO:0005007 IMP     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     boss receptor activity GO:0008288 IEA     fibroblast growth factor binding GO:0017134 IBA     fibroblast growth factor binding GO:0017134 IDA     fibroblast growth factor binding GO:0017134 IPI     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     identical protein binding GO:0042802 IPI     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     MAPK cascade GO:0000165 TAS     skeletal system development GO:0001501 TAS     endochondral ossification GO:0001958 TAS     chondrocyte differentiation GO:0002062 TAS     endochondral bone growth GO:0003416 TAS     chromatin remodeling GO:0006338 IEA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     epidermal growth factor receptor signaling pathway GO:0007173 IEA     cell surface receptor signaling pathway via JAK-STAT GO:0007259 IMP     cell-cell signaling GO:0007267 IEA     multicellular organism development GO:0007275 IBA     positive regulation of cell population proliferation GO:0008284 IGI     positive regulation of cell population proliferation GO:0008284 IMP     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IDA     fibroblast growth factor receptor signaling pathway GO:0008543 IGI     positive regulation of phospholipase activity GO:0010518 IMP     bone mineralization GO:0030282 ISS     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     chondrocyte proliferation GO:0035988 TAS     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 IMP     positive regulation of MAPK cascade GO:0043410 IBA     positive regulation of MAPK cascade GO:0043410 IMP     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     negative regulation of developmental growth GO:0048640 ISS     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 TAS     bone morphogenesis GO:0060349 ISS     bone morphogenesis GO:0060349 TAS     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     bone maturation GO:0070977 ISS     fibroblast growth factor receptor apoptotic signaling pathway GO:1902178 IMP Subcellular Localization     extracellular region GO:0005576 IEA     endoplasmic reticulum GO:0005783 IDA     Golgi apparatus GO:0005794 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     focal adhesion GO:0005925 TAS     cell surface GO:0009986 IEA     transport vesicle GO:0030133 IDA     receptor complex GO:0043235 IBA