Gene description for SYK
Gene name	spleen tyrosine kinase
Gene symbol	SYK
Other names/aliases	p72-Syk
Species	Homo sapiens
Database cross references - SYK
ExoCarta	ExoCarta_6850
Entrez Gene	6850
HGNC	11491
MIM	600085
UniProt	P43405
SYK identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723
Platelets	25332113
Platelets	25332113
Platelets	25332113
Thymus	23844026

Gene ontology annotations for SYK

Molecular Function     ATP binding GO:0005524 IEA     integrin binding GO:0005178 IPI     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IEA     protein tyrosine kinase activity GO:0004713 TAS     protein kinase activity GO:0004672 NAS     non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS     receptor signaling protein tyrosine kinase activity GO:0004716 IEA     protein serine/threonine kinase activity GO:0004674 IDA Biological Process     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 IMP     activation of JUN kinase activity GO:0007257 IEA     viral process GO:0016032 IEA     neutrophil activation involved in immune response GO:0002283 ISS     positive regulation of alpha-beta T cell proliferation GO:0046641 IBA     lymph vessel development GO:0001945 ISS     positive regulation of interleukin-3 biosynthetic process GO:0045401 IEA     neutrophil chemotaxis GO:0030593 IDA     organ morphogenesis GO:0009887 TAS     transcription factor import into nucleus GO:0042991 IMP     leukocyte activation involved in immune response GO:0002366 ISS     defense response to bacterium GO:0042742 ISS     protein phosphorylation GO:0006468 ISS     blood vessel morphogenesis GO:0048514 ISS     regulation of platelet aggregation GO:0090330 ISS     regulation of ERK1 and ERK2 cascade GO:0070372 ISS     positive regulation of gamma-delta T cell differentiation GO:0045588 IEA     positive regulation of B cell differentiation GO:0045579 IMP     blood coagulation GO:0007596 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     positive regulation of mast cell degranulation GO:0043306 IBA     positive regulation of calcium-mediated signaling GO:0050850 IEA     macrophage activation involved in immune response GO:0002281 ISS     positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process GO:0045425 IEA     beta selection GO:0043366 IEA     leukocyte cell-cell adhesion GO:0007159 IDA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     regulation of superoxide anion generation GO:0032928 ISS     regulation of platelet activation GO:0010543 ISS     serotonin secretion by platelet GO:0002554 ISS     leukotriene biosynthetic process GO:0019370 IEA     adaptive immune response GO:0002250 ISS     B cell receptor signaling pathway GO:0050853 ISS     regulation of sequence-specific DNA binding transcription factor activity GO:0051090 IMP     cellular response to molecule of fungal origin GO:0071226 ISS     innate immune response GO:0045087 TAS     positive regulation of cytokine secretion GO:0050715 IEA     positive regulation of cell adhesion mediated by integrin GO:0033630 ISS     positive regulation of alpha-beta T cell differentiation GO:0046638 IEA     regulation of arachidonic acid secretion GO:0090237 ISS     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     angiogenesis GO:0001525 IEA     cell proliferation GO:0008283 TAS     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     platelet activation GO:0030168 TAS     positive regulation of bone resorption GO:0045780 ISS     integrin-mediated signaling pathway GO:0007229 NAS     regulation of phagocytosis GO:0050764 ISS     regulation of neutrophil degranulation GO:0043313 ISS     cell differentiation GO:0030154 IBA Subcellular Localization     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA     early phagosome GO:0032009 ISS     cytosol GO:0005829 TAS     T cell receptor complex GO:0042101 IDA     cytoplasm GO:0005737 IDA     plasma membrane GO:0005886 TAS     B cell receptor complex GO:0019815 IEA     nucleus GO:0005634 IDA     protein complex GO:0043234 IDA