Gene description for CFTR
Gene name	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Gene symbol	CFTR
Other names/aliases	ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1
Species	Homo sapiens
Database cross references - CFTR
ExoCarta	ExoCarta_1080
Entrez Gene	1080
HGNC	1884
MIM	602421
UniProt	P13569
CFTR identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for CFTR

Molecular Function     enzyme binding GO:0019899 IPI     ATP-binding and phosphorylation-dependent chloride channel activity GO:0005224 TAS     chloride channel inhibitor activity GO:0019869 IDA     bicarbonate transmembrane transporter activity GO:0015106 ISS     ATP binding GO:0005524 IEA     chloride channel activity GO:0005254 IDA     chloride transmembrane transporter activity GO:0015108 ISS     PDZ domain binding GO:0030165 IDA     protein binding GO:0005515 IPI     channel-conductance-controlling ATPase activity GO:0005260 NAS Biological Process     intracellular pH elevation GO:0051454 ISS     bicarbonate transport GO:0015701 IEA     chloride transmembrane transport GO:1902476 TAS     response to cytokine GO:0034097 IEA     water transport GO:0006833 IEA     positive regulation of voltage-gated chloride channel activity GO:1902943 IDA     transmembrane transport GO:0055085 TAS     transport GO:0006810 TAS     response to estrogen GO:0043627 IEA     small GTPase mediated signal transduction GO:0007264 TAS     cholesterol transport GO:0030301 IEA     response to drug GO:0042493 IEA     sperm capacitation GO:0048240 ISS     transepithelial chloride transport GO:0030321 IEA     response to peptide hormone GO:0043434 IEA     lung development GO:0030324 IEA     iodide transport GO:0015705 IEA     vasodilation GO:0042311 IEA     cellular response to cAMP GO:0071320 ISS     respiratory gaseous exchange GO:0007585 TAS     cholesterol biosynthetic process GO:0006695 IEA     membrane hyperpolarization GO:0060081 ISS     positive regulation of vasodilation GO:0045909 IEA     cellular response to hormone stimulus GO:0032870 IEA Subcellular Localization     endoplasmic reticulum Sec complex GO:0031205 IDA     chloride channel complex GO:0034707 IEA     plasma membrane GO:0005886 TAS     Golgi-associated vesicle membrane GO:0030660 TAS     early endosome GO:0005769 IDA     basolateral plasma membrane GO:0016323 NAS     cell surface GO:0009986 IDA     cytoplasm GO:0005737 IDA     apical plasma membrane GO:0016324 IDA     lysosomal membrane GO:0005765 TAS     early endosome membrane GO:0031901 IEA     extracellular exosome GO:0070062 IDA     protein complex GO:0043234 IDA     microvillus GO:0005902 IEA     recycling endosome GO:0055037 IDA