Gene description for PDLIM7
Gene name PDZ and LIM domain 7 (enigma)
Gene symbol PDLIM7
Other names/aliases LMP1
LMP3
Species Homo sapiens
 Database cross references - PDLIM7
ExoCarta ExoCarta_9260
Entrez Gene 9260
HGNC 22958
MIM 605903
UniProt Q9NR12  
 PDLIM7 identified in exosomes derived from the following tissue/cell type
B cell lymphoblastoid cells 10878338    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for PDLIM7
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    multicellular organismal development GO:0007275 IEA
    ossification GO:0001503 IEA
    cell differentiation GO:0030154 IEA
    actin cytoskeleton organization GO:0030036 IEA
    receptor-mediated endocytosis GO:0006898 TAS
    positive regulation of osteoblast differentiation GO:0045669 IEA
Subcellular Localization
    focal adhesion GO:0005925 IDA
    ruffle GO:0001726 IEA
    cytoplasm GO:0005737 IEA
    actin cytoskeleton GO:0015629 IDA
    nucleus GO:0005634 IDA
    stress fiber GO:0001725 IEA
 Experiment description of studies that identified PDLIM7 in exosomes
1
Experiment ID 37
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD86
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 10878338    
Organism Homo sapiens
Experiment description Direct immunosuppressive effects of EBV-encoded latent membrane protein 1.
Authors Dukers DF, Meij P, Vervoort MB, Vos W, Scheper RJ, Meijer CJ, Bloemena E, Middeldorp JM
Journal name JIMMU
Publication year 2000
Sample B cell lymphoblastoid cells
Sample name JY
B95-8
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
2
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PDLIM7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMF1  
Two-hybrid Homo sapiens
2 SPP1 6696
Two-hybrid Homo sapiens
3 BSG 682
Two-hybrid Homo sapiens
4 TPM2 7169
Invivo Homo sapiens
Invitro Homo sapiens
5 C1orf65  
Two-hybrid Homo sapiens
6 GFAP 2670
Two-hybrid Homo sapiens
7 UBE2I 7329
Two-hybrid Homo sapiens
8 PRKCZ 5590
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
9 PRKCB 5579
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
10 GEM  
Two-hybrid Homo sapiens
11 MGC5356  
Two-hybrid Homo sapiens
12 RET 5979
Invivo Homo sapiens
13 PAK7  
Two-hybrid Homo sapiens
14 WWP2 11060
Two-hybrid Homo sapiens
15 ZNF165  
Two-hybrid Homo sapiens
16 PRKCA 5578
Invitro Homo sapiens
17 AP5B1 91056
Two-hybrid Homo sapiens
18 C16orf48  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PDLIM7 is involved
No pathways found





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