Gene description for RAF1
Gene name	Raf-1 proto-oncogene, serine/threonine kinase
Gene symbol	RAF1
Other names/aliases	CMD1NN CRAF NS5 Raf-1 c-Raf
Species	Homo sapiens
Database cross references - RAF1
ExoCarta	ExoCarta_5894
Entrez Gene	5894
HGNC	9829
MIM	164760
UniProt	P04049
RAF1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for RAF1

Molecular Function     protein binding GO:0005515 IPI     small GTPase binding GO:0031267 IPI     MAP kinase kinase kinase activity GO:0004709 IEA     mitogen-activated protein kinase kinase binding GO:0031434 IEA     protein serine/threonine kinase activity GO:0004674 IDA     protein heterodimerization activity GO:0046982 IEA     identical protein binding GO:0042802 IPI     protein kinase activity GO:0004672 TAS     ATP binding GO:0005524 IEA     metal ion binding GO:0046872 IEA Biological Process     axon guidance GO:0007411 TAS     protein phosphorylation GO:0006468 TAS     apoptotic process GO:0006915 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     cell proliferation GO:0008283 TAS     innate immune response GO:0045087 TAS     insulin receptor signaling pathway GO:0008286 TAS     activation of adenylate cyclase activity GO:0007190 NAS     MAPK cascade GO:0000165 TAS     regulation of cell motility GO:2000145 TAS     transmembrane transport GO:0055085 TAS     small GTPase mediated signal transduction GO:0007264 TAS     heart development GO:0007507 IEA     response to hypoxia GO:0001666 IEA     positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA     wound healing GO:0042060 TAS     platelet activation GO:0030168 TAS     Ras protein signal transduction GO:0007265 TAS     negative regulation of cell proliferation GO:0008285 IDA     ion transmembrane transport GO:0034220 TAS     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     blood coagulation GO:0007596 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     regulation of Rho protein signal transduction GO:0035023 TAS     signal transduction GO:0007165 TAS     activation of MAPKK activity GO:0000186 TAS     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IEA     synaptic transmission GO:0007268 TAS     somatic stem cell maintenance GO:0035019 IEA     death-inducing signaling complex assembly GO:0071550 IEA     negative regulation of apoptotic process GO:0043066 IDA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     regulation of cell differentiation GO:0045595 TAS     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 TAS     intermediate filament cytoskeleton organization GO:0045104 IEA     epidermal growth factor receptor signaling pathway GO:0007173 TAS     negative regulation of protein complex assembly GO:0031333 IDA     regulation of apoptotic process GO:0042981 TAS Subcellular Localization     cytoplasm GO:0005737 ISS     plasma membrane GO:0005886 TAS     pseudopodium GO:0031143 IEA     cytosol GO:0005829 TAS     mitochondrial outer membrane GO:0005741 TAS     Golgi apparatus GO:0005794 IPI     nucleus GO:0005634 IEA