Gene description for FLT1
Gene name	fms-related tyrosine kinase 1
Gene symbol	FLT1
Other names/aliases	FLT FLT-1 VEGFR-1 VEGFR1
Species	Homo sapiens
Database cross references - FLT1
ExoCarta	ExoCarta_2321
Entrez Gene	2321
HGNC	3763
MIM	165070
UniProt	P17948
FLT1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for FLT1

Molecular Function     VEGF-A-activated receptor activity GO:0036326 IDA     vascular endothelial growth factor-activated receptor activity GO:0005021 IMP     growth factor binding GO:0019838 IPI     placental growth factor-activated receptor activity GO:0036332 IDA     identical protein binding GO:0042802 IEA     protein binding GO:0005515 IPI     transmembrane receptor protein tyrosine kinase activity GO:0004714 TAS     VEGF-B-activated receptor activity GO:0036327 IDA     ATP binding GO:0005524 IEA Biological Process     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     vascular endothelial growth factor signaling pathway GO:0038084 TAS     positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 IDA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     sprouting angiogenesis GO:0002040 IEA     cell migration GO:0016477 IMP     embryonic morphogenesis GO:0048598 ISS     cellular response to vascular endothelial growth factor stimulus GO:0035924 IDA     protein autophosphorylation GO:0046777 IDA     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 IMP     patterning of blood vessels GO:0001569 IEA     positive regulation of angiogenesis GO:0045766 IMP     cell differentiation GO:0030154 IEA     positive regulation of MAP kinase activity GO:0043406 IDA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IDA     positive regulation of cell proliferation GO:0008284 TAS     positive regulation of phospholipase C activity GO:0010863 IMP     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IMP     monocyte chemotaxis GO:0002548 IDA     positive regulation of MAPK cascade GO:0043410 IDA     positive regulation of cell migration GO:0030335 IDA     blood vessel morphogenesis GO:0048514 ISS Subcellular Localization     focal adhesion GO:0005925 IDA     plasma membrane GO:0005886 TAS     receptor complex GO:0043235 IDA     integral component of plasma membrane GO:0005887 IDA     endosome GO:0005768 IEA     extracellular space GO:0005615 TAS