Gene description for CD274 |
Gene name |
CD274 molecule |
Gene symbol |
CD274 |
Other names/aliases |
B7-H B7H1 PD-L1 PDCD1L1 PDCD1LG1 PDL1 |
Species |
Homo sapiens |
Database cross references - CD274 |
ExoCarta |
ExoCarta_29126 |
Entrez Gene |
29126 |
HGNC |
17635 |
MIM |
605402 |
UniProt |
Q9NZQ7
|
CD274 identified in exosomes derived from the following tissue/cell type |
Plasma
|
17076679
|
Urine
|
21595033
|
Urine
|
21595033
|
Urine
|
21595033
|
Gene ontology annotations for CD274 |
|
Experiment description of studies that identified CD274 in exosomes |
1 |
Experiment ID |
43 |
ISEV standards |
✔
EM
|
EV Biophysical techniques |
✘
|
EV Cytosolic markers |
✔
CD83
|
EV Membrane markers |
✘
|
EV Negative markers |
✘
|
EV Particle analysis
|
|
Identified molecule |
protein
|
Identification method |
Western blotting
|
PubMed ID |
17076679
|
Organism |
Homo sapiens |
Experiment description |
Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences. |
Authors |
Sabapatha A, Gercel-Taylor C, Taylor DD |
Journal name |
AJRI
|
Publication year |
2006 |
Sample |
Plasma |
Sample name |
Plasma - Pregnant and not-pregnant women |
Isolation/purification methods |
Size exclusion Ultracentrifugation Immunobeads (CD3, CD19, CD56, CD83, PLAP) |
Flotation density |
-
|
Molecules identified in the study |
Protein |
Methods used in the study |
Western blotting |
|
|
2 |
Experiment ID |
193 |
ISEV standards |
✔
EM
|
EV Biophysical techniques |
✘
|
EV Cytosolic markers |
✔
CD63|CD9
|
EV Membrane markers |
✔
PHB
|
EV Negative markers |
✘
|
EV Particle analysis
|
|
Identified molecule |
protein
|
Identification method |
Mass spectrometry
|
PubMed ID |
21595033
|
Organism |
Homo sapiens |
Experiment description |
Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. |
Authors |
Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC. |
Journal name |
Proteomics
|
Publication year |
2011 |
Sample |
Urine |
Sample name |
Urine - Normal |
Isolation/purification methods |
Differential centrifugation Ultracentrifugation Sucrose density gradient |
Flotation density |
-
|
Molecules identified in the study |
Protein |
Methods used in the study |
Mass spectrometry |
|
|
3 |
Experiment ID |
194 |
ISEV standards |
✘
|
EV Biophysical techniques |
✘
|
EV Cytosolic markers |
✘
|
EV Membrane markers |
✘
|
EV Negative markers |
✘
|
EV Particle analysis
|
|
Identified molecule |
protein
|
Identification method |
Mass spectrometry
|
PubMed ID |
21595033
|
Organism |
Homo sapiens |
Experiment description |
Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. |
Authors |
Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC. |
Journal name |
Proteomics
|
Publication year |
2011 |
Sample |
Urine |
Sample name |
Urine - Patients of basement membrane nephropathy |
Isolation/purification methods |
Differential centrifugation Ultracentrifugation Sucrose density gradient |
Flotation density |
-
|
Molecules identified in the study |
Protein |
Methods used in the study |
Mass spectrometry |
|
|
4 |
Experiment ID |
195 |
ISEV standards |
✘
|
EV Biophysical techniques |
✘
|
EV Cytosolic markers |
✘
|
EV Membrane markers |
✘
|
EV Negative markers |
✘
|
EV Particle analysis
|
|
Identified molecule |
protein
|
Identification method |
Mass spectrometry
|
PubMed ID |
21595033
|
Organism |
Homo sapiens |
Experiment description |
Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. |
Authors |
Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC. |
Journal name |
Proteomics
|
Publication year |
2011 |
Sample |
Urine |
Sample name |
Urine - Patients of early IgA nephropathy |
Isolation/purification methods |
Differential centrifugation Ultracentrifugation Sucrose density gradient |
Flotation density |
-
|
Molecules identified in the study |
Protein |
Methods used in the study |
Mass spectrometry |
|
|
Protein-protein interactions for CD274 |
|
Protein Interactor |
ExoCarta ID |
Identification method |
PubMed |
Species |
No interactions are found.
|
|
Pathways in which CD274 is involved |
|
|
|