Gene description for SUMO2
Gene name small ubiquitin-like modifier 2
Gene symbol SUMO2
Other names/aliases HSMT3
SMT3B
SMT3H2
SUMO3
Smt3A
Species Homo sapiens
 Database cross references - SUMO2
ExoCarta ExoCarta_6613
Vesiclepedia VP_6613
Entrez Gene 6613
HGNC 11125
MIM 603042
UniProt P61956  
 SUMO2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
T lymphocytes 34108659    
 Gene ontology annotations for SUMO2
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    SUMO transferase activity GO:0019789 IEA
    protein tag activity GO:0031386 IBA
    ubiquitin protein ligase binding GO:0031625 IPI
    ubiquitin-like protein ligase binding GO:0044389 IBA
Biological Process
    protein sumoylation GO:0016925 IBA
    protein sumoylation GO:0016925 IDA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    PML body GO:0016605 IDA
    hippocampal mossy fiber to CA3 synapse GO:0098686 IEA
    glutamatergic synapse GO:0098978 IEA
    GABA-ergic synapse GO:0098982 IEA
    presynaptic cytosol GO:0099523 IEA
    postsynaptic cytosol GO:0099524 IEA
 Experiment description of studies that identified SUMO2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
10
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
16
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
17
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
18
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
19
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
24
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
28
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
29
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for SUMO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PCBP2 5094
Two-hybrid Homo sapiens
2 MARCKS 4082
Affinity Capture-MS Homo sapiens
3 PGD 5226
Co-fractionation Homo sapiens
4 CHAF1A  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
5 UBE2H 7328
Affinity Capture-MS Homo sapiens
6 RCOR2 283248
Reconstituted Complex Homo sapiens
7 ATF7IP 55729
Reconstituted Complex Homo sapiens
8 CMTM6 54918
Two-hybrid Homo sapiens
9 TNIP1 10318
Two-hybrid Homo sapiens
10 TP53BP1 7158
Reconstituted Complex Homo sapiens
11 GATAD2B 57459
Reconstituted Complex Homo sapiens
12 ATPIF1 93974
Affinity Capture-MS Homo sapiens
13 NOP58 51602
Affinity Capture-MS Homo sapiens
14 PTMS 5763
Affinity Capture-MS Homo sapiens
15 ANP32A 8125
Affinity Capture-MS Homo sapiens
16 MDN1 23195
Reconstituted Complex Homo sapiens
17 USPL1  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
18 PTMA 5757
Affinity Capture-MS Homo sapiens
19 RNF4 6047
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
20 MSH2 4436
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
21 PPIE 10450
Two-hybrid Homo sapiens
22 TOP2B 7155
Reconstituted Complex Homo sapiens
23 TRIM26 7726
Reconstituted Complex Homo sapiens
24 POGZ 23126
Reconstituted Complex Homo sapiens
25 NACA 4666
Affinity Capture-MS Homo sapiens
26 DDX17 10521
Reconstituted Complex Homo sapiens
27 Rnf4  
Biochemical Activity Mus musculus
28 BRCA1 672
Affinity Capture-MS Homo sapiens
29 EME1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
30 TRIM33 51592
Affinity Capture-MS Homo sapiens
31 SETX  
Two-hybrid Homo sapiens
32 UBC 7316
Affinity Capture-Western Homo sapiens
33 MRE11A 4361
Reconstituted Complex Homo sapiens
34 CALM1 801
Affinity Capture-MS Homo sapiens
35 CTNND1 1500
Reconstituted Complex Homo sapiens
36 ZBTB1  
Affinity Capture-MS Homo sapiens
37 PARK7 11315
Affinity Capture-MS Homo sapiens
38 HDAC4  
Affinity Capture-MS Homo sapiens
39 SETDB1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
40 SOX2  
Affinity Capture-MS Homo sapiens
41 CKB 1152
Affinity Capture-MS Homo sapiens
42 CHD4 1108
Reconstituted Complex Homo sapiens
43 PELP1 27043
Reconstituted Complex Homo sapiens
44 ZBTB33  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
45 PGK1 5230
Affinity Capture-MS Homo sapiens
46 SENP3 26168
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
47 PRDX3 10935
Affinity Capture-MS Homo sapiens
48 SSRP1 6749
Reconstituted Complex Homo sapiens
49 TGFB1 7040
Affinity Capture-MS Homo sapiens
50 KLF8  
Proximity Label-MS Homo sapiens
51 ENO2 2026
Co-fractionation Homo sapiens
52 C18orf25 147339
Two-hybrid Homo sapiens
53 SENP1  
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
54 NUP153 9972
Affinity Capture-MS Homo sapiens
55 AHSG 197
Affinity Capture-MS Homo sapiens
56 ANP32B 10541
Affinity Capture-MS Homo sapiens
57 AR 367
Affinity Capture-MS Homo sapiens
58 BRCC3 79184
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
59 CUX1 1523
Reconstituted Complex Homo sapiens
60 ETV6  
Proximity Label-MS Homo sapiens
61 MDC1  
Reconstituted Complex Homo sapiens
62 TDP2 51567
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
63 YWHAG 7532
Affinity Capture-MS Homo sapiens
64 BASP1 10409
Affinity Capture-MS Homo sapiens
65 TDG 6996
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
66 SMC2 10592
Cross-Linking-MS (XL-MS) Homo sapiens
67 KRT5 3852
Affinity Capture-MS Homo sapiens
68 ZNF451 26036
Reconstituted Complex Homo sapiens
69 HSP90B1 7184
Affinity Capture-MS Homo sapiens
70 ARC  
Affinity Capture-Western Homo sapiens
71 SMCHD1 23347
Reconstituted Complex Homo sapiens
72 ATRX 546
Reconstituted Complex Homo sapiens
73 EEF1G 1937
Reconstituted Complex Homo sapiens
74 ATG16L1 55054
Affinity Capture-MS Homo sapiens
75 PGAM1 5223
Affinity Capture-MS Homo sapiens
76 TEAD3  
Two-hybrid Homo sapiens
77 SEC23A 10484
Co-fractionation Homo sapiens
78 MUS81  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
79 PSAP 5660
Co-fractionation Homo sapiens
80 CSNK2B 1460
Two-hybrid Homo sapiens
81 RCOR3  
Reconstituted Complex Homo sapiens
82 SOD1 6647
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 EEF1A1 1915
Reconstituted Complex Homo sapiens
84 UIMC1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
85 TRIP12 9320
Cross-Linking-MS (XL-MS) Homo sapiens
86 PRKDC 5591
Reconstituted Complex Homo sapiens
87 EXOSC9 5393
Reconstituted Complex Homo sapiens
88 YWHAB 7529
Affinity Capture-MS Homo sapiens
89 PFN1 5216
Affinity Capture-MS Homo sapiens
90 ALAS1  
Two-hybrid Homo sapiens
91 ZMAT3  
Reconstituted Complex Homo sapiens
92 EIF6 3692
Affinity Capture-MS Homo sapiens
93 PPIB 5479
Affinity Capture-MS Homo sapiens
94 NOP2 4839
Reconstituted Complex Homo sapiens
95 SENP2 59343
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
96 TRIML2  
Reconstituted Complex Homo sapiens
97 Rcc1  
Affinity Capture-MS Mus musculus
98 DDX21 9188
Reconstituted Complex Homo sapiens
99 TUBA1B 10376
Reconstituted Complex Homo sapiens
100 USP11 8237
Biochemical Activity Homo sapiens
101 RPL4 6124
Reconstituted Complex Homo sapiens
102 SAE1 10055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 PIAS4  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
104 RBM8A 9939
Affinity Capture-MS Homo sapiens
105 BRE 9577
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
106 SIMC1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
107 ELK3  
Proximity Label-MS Homo sapiens
108 NBN 4683
Reconstituted Complex Homo sapiens
109 ZMYM3  
Reconstituted Complex Homo sapiens
110 IRF7  
Co-localization Homo sapiens
111 CTSA 5476
Co-fractionation Homo sapiens
112 CALR 811
Affinity Capture-MS Homo sapiens
113 UBE2I 7329
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
114 ANKRD35  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
115 LF1  
Far Western
116 VCP 7415
Affinity Capture-MS Homo sapiens
117 HMGN1  
Affinity Capture-MS Homo sapiens
118 SLX4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
119 TRIM63  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
120 PIAS2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
121 SUMO2 6613
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
122 ENO1 2023
Reconstituted Complex Homo sapiens
123 RBBP7 5931
Reconstituted Complex Homo sapiens
124 PML 5371
Co-localization Homo sapiens
125 BGLF1  
Far Western
126 BGLF4  
Far Western
Reconstituted Complex
127 ZBTB21  
Affinity Capture-MS Homo sapiens
128 Ube2i  
Affinity Capture-MS Mus musculus
Two-hybrid Mus musculus
129 DDX39B 7919
Affinity Capture-MS Homo sapiens
130 PEBP1 5037
Affinity Capture-MS Homo sapiens
131 ERCC4  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
132 DNM1L 10059
Affinity Capture-MS Homo sapiens
133 USP28 57646
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
134 DAXX  
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
135 CARS 833
Reconstituted Complex Homo sapiens
136 ZBED1  
Reconstituted Complex Homo sapiens
137 SP100 6672
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
138 IGBP1 3476
Co-fractionation Homo sapiens
139 TPM3 7170
Affinity Capture-MS Homo sapiens
140 ZMYM4  
Reconstituted Complex Homo sapiens
141 RNF168  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
142 NUMA1 4926
Reconstituted Complex Homo sapiens
143 TMPO 7112
Reconstituted Complex Homo sapiens
144 BRF1  
Affinity Capture-MS Homo sapiens
145 ZBTB2 57621
Reconstituted Complex Homo sapiens
146 TUBB 203068
Reconstituted Complex Homo sapiens
147 EBNA3A  
Far Western
148 Rnf111  
Biochemical Activity Mus musculus
149 IPO5 3843
Reconstituted Complex Homo sapiens
150 FANCD2  
Affinity Capture-MS Homo sapiens
151 Nup98  
Affinity Capture-MS Mus musculus
152 LAS1L 81887
Reconstituted Complex Homo sapiens
153 AHCYL1 10768
Co-fractionation Homo sapiens
154 BAZ1B 9031
Reconstituted Complex Homo sapiens
155 SOX6  
Proximity Label-MS Homo sapiens
156 MAF1  
Two-hybrid Homo sapiens
157 TPR 7175
Reconstituted Complex Homo sapiens
158 HSPE1 3336
Affinity Capture-MS Homo sapiens
159 MAD1L1  
Co-localization Homo sapiens
160 TPI1 7167
Affinity Capture-MS Homo sapiens
161 GGH 8836
Affinity Capture-MS Homo sapiens
162 AHNAK 79026
Reconstituted Complex Homo sapiens
163 HDAC2 3066
Reconstituted Complex Homo sapiens
164 ANXA1 301
Reconstituted Complex Homo sapiens
165 ANXA5 308
Affinity Capture-MS Homo sapiens
166 BLRF1  
Far Western
167 BLM 641
Two-hybrid Homo sapiens
168 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
Reconstituted Complex Homo sapiens
169 BGLF2  
Far Western
170 ALDOA 226
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
171 TUBB4B 10383
Reconstituted Complex Homo sapiens
172 PDIA3 2923
Affinity Capture-MS Homo sapiens
173 EGFR 1956
Negative Genetic Homo sapiens
174 HSD17B10 3028
Affinity Capture-MS Homo sapiens
175 PIAS3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
176 DPP7 29952
Affinity Capture-MS Homo sapiens
177 RBBP4 5928
Reconstituted Complex Homo sapiens
178 RPRD1B 58490
Affinity Capture-MS Homo sapiens
179 SENP7  
Protein-peptide Homo sapiens
180 HNF4A  
Proximity Label-MS Homo sapiens
181 MAPK6  
Affinity Capture-MS Homo sapiens
182 UBA2 10054
Affinity Capture-MS Homo sapiens
183 PIAS1 8554
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
184 Nup107  
Affinity Capture-MS Mus musculus
185 XRCC6 2547
Reconstituted Complex Homo sapiens
186 ZBTB39  
Two-hybrid Homo sapiens
187 CEP78 84131
Affinity Capture-MS Homo sapiens
188 SELENBP1 8991
Co-fractionation Homo sapiens
189 SET 6418
Affinity Capture-MS Homo sapiens
190 SLC22A2 6582
Two-hybrid Homo sapiens
191 USP7 7874
Biochemical Activity Homo sapiens
192 RAD54L2  
Reconstituted Complex Homo sapiens
193 PHF5A 84844
Reconstituted Complex Homo sapiens
194 HSPA1A 3303
Reconstituted Complex Homo sapiens
195 ZBTB25  
Reconstituted Complex Homo sapiens
196 HP1BP3 50809
Reconstituted Complex Homo sapiens
197 ACRC  
Affinity Capture-Western Homo sapiens
198 STMN1 3925
Affinity Capture-MS Homo sapiens
199 FKBP3 2287
Affinity Capture-MS Homo sapiens
200 EBNA3B  
Far Western
201 SENP5  
Biochemical Activity Homo sapiens
202 NEDD4 4734
Affinity Capture-MS Homo sapiens
203 ABCA8 10351
Cross-Linking-MS (XL-MS) Homo sapiens
204 HSPA9 3313
Reconstituted Complex Homo sapiens
205 MYB  
Reconstituted Complex Homo sapiens
206 HNRNPH1 3187
Reconstituted Complex Homo sapiens
207 BRD3 8019
Cross-Linking-MS (XL-MS) Homo sapiens
208 ZMYM2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
209 SUPT16H 11198
Reconstituted Complex Homo sapiens
210 HMGB1P1 10357
Affinity Capture-MS Homo sapiens
211 ZCCHC12  
Two-hybrid Homo sapiens
212 XRCC5 7520
Reconstituted Complex Homo sapiens
213 BAZ1A 11177
Reconstituted Complex Homo sapiens
214 ATIC 471
Co-fractionation Homo sapiens
215 Senp2  
Reconstituted Complex Rattus norvegicus
216 MTA2 9219
Reconstituted Complex Homo sapiens
217 SDHAF2 54949
Co-fractionation Homo sapiens
218 BBLF2-BBLF3  
Far Western
219 EXOSC10 5394
Reconstituted Complex Homo sapiens
220 RNF43  
Proximity Label-MS Homo sapiens
221 BZLF2  
Far Western
222 ARRB2 409
Reconstituted Complex Homo sapiens
223 TANK 10010
Affinity Capture-Western Homo sapiens
224 PRKCSH 5589
Affinity Capture-MS Homo sapiens
225 TRIM24  
Affinity Capture-MS Homo sapiens
226 PARP1 142
Affinity Capture-MS Homo sapiens
227 BKRF1  
Affinity Capture-Western
Reconstituted Complex
228 ZCCHC7  
Two-hybrid Homo sapiens
229 USP25  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
230 BAD  
Two-hybrid Homo sapiens
231 TP53 7157
Affinity Capture-MS Homo sapiens
232 HOMEZ  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
233 RPL3 6122
Reconstituted Complex Homo sapiens
234 HSPA8 3312
Reconstituted Complex Homo sapiens
235 MTA1 9112
Reconstituted Complex Homo sapiens
236 PDIA4 9601
Affinity Capture-MS Homo sapiens
237 SENP6  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
238 SLX4IP  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
239 DDX3X 1654
Reconstituted Complex Homo sapiens
240 USP36  
Reconstituted Complex Homo sapiens
241 ATXN7  
Reconstituted Complex Homo sapiens
242 CHAMP1  
Reconstituted Complex Homo sapiens
243 ZMYM5 9205
Two-hybrid Homo sapiens
244 TEX10 54881
Reconstituted Complex Homo sapiens
245 NPEPL1 79716
Co-fractionation Homo sapiens
246 WRN 7486
Two-hybrid Homo sapiens
247 SHFM1 7979
Affinity Capture-MS Homo sapiens
248 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
249 HDAC1 3065
Reconstituted Complex Homo sapiens
250 TKT 7086
Affinity Capture-MS Homo sapiens
251 FAM175A  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
252 SEC23B 10483
Co-fractionation Homo sapiens
253 ZHX1  
Two-hybrid Homo sapiens
254 MKI67  
Reconstituted Complex Homo sapiens
255 HNRNPK 3190
Reconstituted Complex Homo sapiens
256 TUBB6 84617
Reconstituted Complex Homo sapiens
257 RAD50 10111
Reconstituted Complex Homo sapiens
258 TOP2A 7153
Reconstituted Complex Homo sapiens
259 DCD 117159
Reconstituted Complex Homo sapiens
260 MIF 4282
Affinity Capture-MS Homo sapiens
261 MAST2  
Two-hybrid Homo sapiens
262 UBB 7314
Affinity Capture-MS Homo sapiens
263 CEBPA  
Protein-peptide Homo sapiens
264 KDM1A 23028
Reconstituted Complex Homo sapiens
265 RUVBL1 8607
Reconstituted Complex Homo sapiens
266 ZNF496  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
267 Senp1  
Reconstituted Complex Mus musculus
268 PFKM 5213
Reconstituted Complex Homo sapiens
269 KIF18B 146909
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
270 CAD 790
Reconstituted Complex Homo sapiens
271 TRIM28 10155
Reconstituted Complex Homo sapiens
272 SSSCA1 10534
Co-fractionation Homo sapiens
273 RNF111 54778
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
274 HNRNPF 3185
Reconstituted Complex Homo sapiens
275 Ranbp2  
Affinity Capture-MS Mus musculus
276 TOPORS  
Two-hybrid Homo sapiens
277 HIPK2 28996
Reconstituted Complex Homo sapiens
278 HNF1B  
Proximity Label-MS Homo sapiens
279 KRAS 3845
Negative Genetic Homo sapiens
280 SUMO3 6612
Affinity Capture-MS Homo sapiens
281 SOBP  
Reconstituted Complex Homo sapiens
282 CASP8AP2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
283 FABP5 2171
Affinity Capture-MS Homo sapiens
284 CHAF1B  
Reconstituted Complex Homo sapiens
285 VIM 7431
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
286 PHF8  
Reconstituted Complex Homo sapiens
287 NOL9 79707
Reconstituted Complex Homo sapiens
288 RCOR1  
Reconstituted Complex Homo sapiens
289 RANBP2 5903
Two-hybrid Homo sapiens
290 EP300 2033
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
291 CHD3 1107
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
292 BGLF5  
Far Western
293 TRAF1 7185
Reconstituted Complex Homo sapiens
294 PARN  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SUMO2 is involved
PathwayEvidenceSource
DNA Double-Strand Break Repair TAS Reactome
DNA Repair TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Formation of Incision Complex in GG-NER TAS Reactome
Gene expression (Transcription) IEA Reactome
Global Genome Nucleotide Excision Repair (GG-NER) TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Homology Directed Repair TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Metabolism of steroids TAS Reactome
Nucleotide Excision Repair TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein modification IEA Reactome
Processing and activation of SUMO IEA Reactome
Processing and activation of SUMO TAS Reactome
Processing of DNA double-strand break ends TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
SUMO E3 ligases SUMOylate target proteins TAS Reactome
SUMO E3 ligases SUMOylate target proteins IEA Reactome
SUMO is conjugated to E1 (UBA2:SAE1) IEA Reactome
SUMO is proteolytically processed TAS Reactome
SUMO is transferred from E1 to E2 (UBE2I, UBC9) IEA Reactome
SUMOylation TAS Reactome
SUMOylation IEA Reactome
SUMOylation of chromatin organization proteins TAS Reactome
SUMOylation of DNA damage response and repair proteins TAS Reactome
SUMOylation of DNA replication proteins TAS Reactome
SUMOylation of intracellular receptors TAS Reactome
SUMOylation of intracellular receptors IEA Reactome
SUMOylation of RNA binding proteins TAS Reactome
SUMOylation of SUMOylation proteins TAS Reactome
SUMOylation of transcription cofactors TAS Reactome
SUMOylation of transcription factors TAS Reactome
Vitamin D (calciferol) metabolism TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here