Gene description for CALCOCO1
Gene name calcium binding and coiled-coil domain 1
Gene symbol CALCOCO1
Other names/aliases Cocoa
PP13275
calphoglin
Species Homo sapiens
 Database cross references - CALCOCO1
ExoCarta ExoCarta_57658
Vesiclepedia VP_57658
Entrez Gene 57658
HGNC 29306
UniProt Q9P1Z2  
 CALCOCO1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CALCOCO1
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    chromatin binding GO:0003682 IEA
    transcription coregulator activity GO:0003712 IDA
    transcription coactivator activity GO:0003713 IBA
    transcription coactivator activity GO:0003713 IMP
    transcription coactivator activity GO:0003713 ISS
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IPI
    nuclear receptor coactivator activity GO:0030374 IDA
    sequence-specific DNA binding GO:0043565 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    signal transduction GO:0007165 ISS
    positive regulation of gene expression GO:0010628 IDA
    Wnt signaling pathway GO:0016055 IEA
    nuclear receptor-mediated steroid hormone signaling pathway GO:0030518 ISS
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
Subcellular Localization
    chromatin GO:0000785 IEA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified CALCOCO1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CALCOCO1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATG16L1 55054
Affinity Capture-MS Homo sapiens
2 GABARAPL1 23710
Affinity Capture-Western Homo sapiens
3 RALBP1 10928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MAFK 7975
Affinity Capture-MS Homo sapiens
5 KRT37 8688
Affinity Capture-MS Homo sapiens
6 SCHIP1  
Affinity Capture-MS Homo sapiens
7 GRIK2  
Two-hybrid Homo sapiens
8 AP2B1 163
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MAFF 23764
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CA10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 NEDD4 4734
Biochemical Activity Homo sapiens
12 FAS 355
Proximity Label-MS Homo sapiens
13 SYCE1  
Affinity Capture-MS Homo sapiens
14 TBC1D17 79735
Two-hybrid Homo sapiens
15 FOSL1  
Two-hybrid Homo sapiens
16 AURKA 6790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CTNNB1 1499
Phenotypic Enhancement Homo sapiens
18 KRT14 3861
Affinity Capture-MS Homo sapiens
19 TXLNB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 MAP1LC3B 81631
Affinity Capture-Western Homo sapiens
21 GABARAPL2 11345
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
22 Ndc80  
Affinity Capture-MS Mus musculus
23 SMURF1 57154
Biochemical Activity Homo sapiens
24 ADRBK1 156
Affinity Capture-MS Homo sapiens
25 BFSP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CYTH1 9267
Affinity Capture-MS Homo sapiens
27 CWF19L2  
Two-hybrid Homo sapiens
28 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
29 RABGGTB 5876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 FOSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 APP 351
Reconstituted Complex Homo sapiens
32 AP2M1 1173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 DUSP13  
Two-hybrid Homo sapiens
34 PCBD1 5092
Two-hybrid Homo sapiens
35 CEP19  
Two-hybrid Homo sapiens
36 KRT15 3866
Two-hybrid Homo sapiens
37 C10orf88  
Affinity Capture-MS Homo sapiens
38 GABARAP 11337
Affinity Capture-Western Homo sapiens
39 FAM161A  
Two-hybrid Homo sapiens
40 TPM3P9  
Affinity Capture-MS Homo sapiens
41 SH3GL3  
Two-hybrid Homo sapiens
42 CRYBA2  
Two-hybrid Homo sapiens
43 NDC80 10403
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
44 CYP51A1 1595
Affinity Capture-MS Homo sapiens
45 KRT23  
Affinity Capture-MS Homo sapiens
46 MAP1LC3A 84557
Affinity Capture-Western Homo sapiens
47 CYTH3 9265
Two-hybrid Homo sapiens
48 SRP9 6726
Affinity Capture-MS Homo sapiens
49 SLU7  
Affinity Capture-MS Homo sapiens
50 APTX  
Two-hybrid Homo sapiens
51 KRT19 3880
Proximity Label-MS Homo sapiens
52 SRP14 6727
Affinity Capture-MS Homo sapiens
53 KRT31 3881
Affinity Capture-MS Homo sapiens
54 ISOC1 51015
Two-hybrid Homo sapiens
55 KRT16 3868
Affinity Capture-MS Homo sapiens
56 TBC1D15 64786
Two-hybrid Homo sapiens
57 EP300 2033
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
58 MAP1LC3C  
Affinity Capture-Western Homo sapiens
59 TPM3 7170
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CALCOCO1 is involved
No pathways found





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