Gene description for NOTCH1
Gene name notch 1
Gene symbol NOTCH1
Other names/aliases AOS5
AOVD1
TAN1
hN1
Species Homo sapiens
 Database cross references - NOTCH1
ExoCarta ExoCarta_4851
Vesiclepedia VP_4851
Entrez Gene 4851
HGNC 7881
MIM 190198
UniProt P46531  
 NOTCH1 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 19837982    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for NOTCH1
Molecular Function
    cis-regulatory region sequence-specific DNA binding GO:0000987 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    transcription coactivator activity GO:0003713 IDA
    transcription coactivator activity GO:0003713 ISS
    enzyme inhibitor activity GO:0004857 ISS
    transmembrane signaling receptor activity GO:0004888 IDA
    Notch binding GO:0005112 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 ISS
    chromatin DNA binding GO:0031490 IEA
    identical protein binding GO:0042802 IPI
    transcription regulator activator activity GO:0140537 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    luteolysis GO:0001554 IEA
    in utero embryonic development GO:0001701 IEA
    epithelial to mesenchymal transition GO:0001837 IMP
    epithelial to mesenchymal transition GO:0001837 ISS
    liver development GO:0001889 IEA
    heart looping GO:0001947 ISS
    sprouting angiogenesis GO:0002040 IEA
    positive regulation of neuroblast proliferation GO:0002052 IEA
    inhibition of neuroepithelial cell differentiation GO:0002085 IEA
    inflammatory response to antigenic stimulus GO:0002437 IEA
    outflow tract morphogenesis GO:0003151 IMP
    endocardium development GO:0003157 ISS
    endocardium morphogenesis GO:0003160 ISS
    atrioventricular node development GO:0003162 IEA
    coronary vein morphogenesis GO:0003169 ISS
    aortic valve morphogenesis GO:0003180 IMP
    aortic valve morphogenesis GO:0003180 ISS
    aortic valve morphogenesis GO:0003180 TAS
    atrioventricular valve morphogenesis GO:0003181 ISS
    coronary sinus valve morphogenesis GO:0003182 IEA
    pulmonary valve morphogenesis GO:0003184 IMP
    pulmonary valve morphogenesis GO:0003184 ISS
    mitral valve formation GO:0003192 IMP
    epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 ISS
    endocardial cushion morphogenesis GO:0003203 ISS
    cardiac chamber formation GO:0003207 ISS
    cardiac ventricle morphogenesis GO:0003208 ISS
    cardiac atrium morphogenesis GO:0003209 ISS
    cardiac right atrium morphogenesis GO:0003213 ISS
    cardiac left ventricle morphogenesis GO:0003214 ISS
    cardiac right ventricle formation GO:0003219 IEA
    ventricular trabecula myocardium morphogenesis GO:0003222 ISS
    growth involved in heart morphogenesis GO:0003241 ISS
    negative regulation of cell proliferation involved in heart valve morphogenesis GO:0003252 ISS
    Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation GO:0003270 IEA
    cell migration involved in endocardial cushion formation GO:0003273 ISS
    negative regulation of extracellular matrix constituent secretion GO:0003332 ISS
    pericardium morphogenesis GO:0003344 ISS
    regulation of DNA-templated transcription GO:0006355 TAS
    regulation of transcription by RNA polymerase II GO:0006357 ISS
    transcription by RNA polymerase II GO:0006366 IEA
    protein import into nucleus GO:0006606 IEA
    immune response GO:0006955 NAS
    humoral immune response GO:0006959 IEA
    Notch signaling pathway GO:0007219 IBA
    Notch signaling pathway GO:0007219 IDA
    Notch signaling pathway GO:0007219 IMP
    Notch signaling pathway GO:0007219 ISS
    Notch signaling pathway GO:0007219 TAS
    positive regulation of transcription of Notch receptor target GO:0007221 ISS
    spermatogenesis GO:0007283 IEA
    determination of left/right symmetry GO:0007368 ISS
    compartment pattern specification GO:0007386 IEA
    axon guidance GO:0007411 IBA
    foregut morphogenesis GO:0007440 IEA
    endoderm development GO:0007492 IEA
    heart development GO:0007507 IMP
    positive regulation of cell population proliferation GO:0008284 IDA
    positive regulation of cell population proliferation GO:0008284 IMP
    negative regulation of cell population proliferation GO:0008285 IDA
    auditory receptor cell fate commitment GO:0009912 IEA
    epidermal cell fate specification GO:0009957 IEA
    negative regulation of cardiac muscle hypertrophy GO:0010614 ISS
    positive regulation of gene expression GO:0010628 ISS
    negative regulation of gene expression GO:0010629 IDA
    negative regulation of cardiac muscle cell apoptotic process GO:0010667 IEA
    negative regulation of cell-substrate adhesion GO:0010812 IDA
    negative regulation of myotube differentiation GO:0010832 IEA
    mesenchymal cell development GO:0014031 ISS
    regulation of somitogenesis GO:0014807 IEA
    calcium-ion regulated exocytosis GO:0017156 IEA
    cell differentiation in spinal cord GO:0021515 IEA
    neural tube development GO:0021915 IEA
    protein catabolic process GO:0030163 IEA
    keratinocyte differentiation GO:0030216 IEA
    negative regulation of ossification GO:0030279 ISS
    lung development GO:0030324 IEA
    positive regulation of cell migration GO:0030335 ISS
    positive regulation of BMP signaling pathway GO:0030513 ISS
    negative regulation of BMP signaling pathway GO:0030514 ISS
    forebrain development GO:0030900 IEA
    hair follicle morphogenesis GO:0031069 IEA
    animal organ regeneration GO:0031100 IEA
    response to muramyl dipeptide GO:0032495 IEA
    response to lipopolysaccharide GO:0032496 IEA
    negative regulation of collagen biosynthetic process GO:0032966 IEA
    embryonic hindlimb morphogenesis GO:0035116 IEA
    tube formation GO:0035148 IMP
    skeletal muscle cell differentiation GO:0035914 IEA
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IDA
    tissue regeneration GO:0042246 IEA
    retinal cone cell differentiation GO:0042670 IEA
    negative regulation of catalytic activity GO:0043086 ISS
    positive regulation of viral genome replication GO:0045070 IEA
    positive regulation of endothelial cell differentiation GO:0045603 IEA
    negative regulation of inner ear auditory receptor cell differentiation GO:0045608 IEA
    positive regulation of keratinocyte differentiation GO:0045618 IEA
    negative regulation of myoblast differentiation GO:0045662 IMP
    negative regulation of osteoblast differentiation GO:0045668 ISS
    positive regulation of Notch signaling pathway GO:0045747 IEA
    negative regulation of DNA-templated transcription GO:0045892 ISS
    positive regulation of DNA-templated transcription GO:0045893 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    negative regulation of calcium ion-dependent exocytosis GO:0045955 IEA
    positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 ISS
    negative regulation of photoreceptor cell differentiation GO:0046533 IEA
    positive regulation of Ras protein signal transduction GO:0046579 IDA
    somatic stem cell division GO:0048103 IEA
    astrocyte differentiation GO:0048708 IEA
    oligodendrocyte differentiation GO:0048709 IEA
    positive regulation of astrocyte differentiation GO:0048711 ISS
    negative regulation of oligodendrocyte differentiation GO:0048715 ISS
    branching morphogenesis of an epithelial tube GO:0048754 IEA
    homeostasis of number of cells within a tissue GO:0048873 ISS
    epithelial cell proliferation GO:0050673 IEA
    positive regulation of epithelial cell proliferation GO:0050679 IEA
    negative regulation of epithelial cell proliferation GO:0050680 IEA
    negative regulation of neurogenesis GO:0050768 ISS
    positive regulation of smooth muscle cell differentiation GO:0051152 IDA
    cardiac muscle tissue morphogenesis GO:0055008 ISS
    cardiac muscle cell proliferation GO:0060038 IEA
    positive regulation of cardiac muscle cell proliferation GO:0060045 ISS
    negative regulation of glial cell proliferation GO:0060253 ISS
    cilium assembly GO:0060271 ISS
    cardiac epithelial to mesenchymal transition GO:0060317 ISS
    negative regulation of cell adhesion molecule production GO:0060354 IMP
    cardiac muscle cell myoblast differentiation GO:0060379 ISS
    cardiac septum morphogenesis GO:0060411 ISS
    ventricular septum morphogenesis GO:0060412 IMP
    secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 IEA
    prostate gland epithelium morphogenesis GO:0060740 IEA
    regulation of epithelial cell proliferation involved in prostate gland development GO:0060768 IEA
    arterial endothelial cell differentiation GO:0060842 ISS
    venous endothelial cell differentiation GO:0060843 ISS
    cardiac vascular smooth muscle cell development GO:0060948 ISS
    endocardial cell differentiation GO:0060956 ISS
    vasculogenesis involved in coronary vascular morphogenesis GO:0060979 ISS
    coronary artery morphogenesis GO:0060982 ISS
    neuroendocrine cell differentiation GO:0061101 IEA
    regulation of cell adhesion involved in heart morphogenesis GO:0061344 IEA
    heart trabecula morphogenesis GO:0061384 ISS
    positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 ISS
    negative regulation of biomineral tissue development GO:0070168 ISS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    left/right axis specification GO:0070986 IEA
    cellular response to tumor cell GO:0071228 IDA
    cellular response to follicle-stimulating hormone stimulus GO:0071372 IDA
    cellular response to hypoxia GO:0071456 ISS
    distal tubule development GO:0072017 IEA
    collecting duct development GO:0072044 IEA
    regulation of stem cell proliferation GO:0072091 IEA
    glomerular mesangial cell development GO:0072144 IEA
    epithelial cell fate commitment GO:0072148 IEA
    T-helper 17 type immune response GO:0072538 IEA
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IEA
    neuronal stem cell population maintenance GO:0097150 IEP
    interleukin-17-mediated signaling pathway GO:0097400 IEA
    chemical synaptic transmission, postsynaptic GO:0099565 IEA
    negative regulation of cold-induced thermogenesis GO:0120163 ISS
    regulation of extracellular matrix assembly GO:1901201 ISS
    apoptotic process involved in embryonic digit morphogenesis GO:1902263 IEA
    positive regulation of apoptotic process involved in morphogenesis GO:1902339 ISS
    positive regulation of aorta morphogenesis GO:1903849 IEA
    negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 IMP
    negative regulation of stem cell differentiation GO:2000737 IMP
    negative regulation of anoikis GO:2000811 IMP
    negative regulation of pro-B cell differentiation GO:2000974 ISS
    negative regulation of endothelial cell chemotaxis GO:2001027 IDA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    acrosomal vesicle GO:0001669 IEA
    MAML1-RBP-Jkappa- ICN1 complex GO:0002193 IDA
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 ISS
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 TAS
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    adherens junction GO:0005912 ISS
    cell surface GO:0009986 IBA
    endosome membrane GO:0010008 TAS
    apical plasma membrane GO:0016324 ISS
    late endosome membrane GO:0031902 IEA
    receptor complex GO:0043235 IBA
    receptor complex GO:0043235 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    postsynaptic density membrane GO:0098839 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified NOTCH1 in sEVs
1
Experiment ID 21
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NOTCH1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Affinity Capture-MS Homo sapiens
2 MCM3 4172
Affinity Capture-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 TRAPPC9 83696
Affinity Capture-MS Homo sapiens
5 WDR6 11180
Affinity Capture-MS Homo sapiens
6 NOTCH3 4854
Phenotypic Suppression Homo sapiens
Affinity Capture-MS Homo sapiens
7 ARHGEF2 9181
Affinity Capture-MS Homo sapiens
8 XIAP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 CCT3 7203
Affinity Capture-MS Homo sapiens
10 OCLN 100506658
Proximity Label-MS Homo sapiens
11 PRKCD 5580
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
12 MARCKS 4082
Proximity Label-MS Homo sapiens
13 WWP1 11059
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
14 GJA1 2697
Proximity Label-MS Homo sapiens
15 TOP2B 7155
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
16 RFC4 5984
Affinity Capture-MS Homo sapiens
17 DLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 ANAPC5 51433
Affinity Capture-MS Homo sapiens
19 KPNB1 3837
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
20 DDX17 10521
Affinity Capture-MS Homo sapiens
21 CFC1  
Affinity Capture-MS Homo sapiens
22 DHX8 1659
Affinity Capture-MS Homo sapiens
23 MAGEA1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
24 LGALS1 3956
Affinity Capture-MS Homo sapiens
25 PRKAA1 5562
Affinity Capture-MS Homo sapiens
26 HSP90AB1 3326
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 ANAPC1 64682
Affinity Capture-MS Homo sapiens
28 CAND1 55832
Affinity Capture-MS Homo sapiens
29 IGFBP4 3487
Affinity Capture-MS Homo sapiens
30 TRIM32 22954
Affinity Capture-MS Homo sapiens
31 APBB1  
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
32 PIK3CA 5290
Affinity Capture-Western Homo sapiens
33 STX4 6810
Proximity Label-MS Homo sapiens
34 DLL1  
Reconstituted Complex Homo sapiens
35 APP 351
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
36 TGFBR1 7046
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
37 ANKRD44 91526
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 TRIM28 10155
Affinity Capture-MS Homo sapiens
39 NCKAP1L 3071
Affinity Capture-MS Homo sapiens
40 ZMIZ1 57178
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
41 JAG1 182
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
42 ZNF74  
Affinity Capture-MS Homo sapiens
43 TCF12  
Affinity Capture-MS Homo sapiens
44 RANBP10 57610
Affinity Capture-MS Homo sapiens
45 TBL1XR1 79718
Affinity Capture-MS Homo sapiens
46 TRIM3 10612
Affinity Capture-Western Homo sapiens
47 ZNF707  
Affinity Capture-MS Homo sapiens
48 CLEC2B  
Affinity Capture-MS Homo sapiens
49 HEY1  
Negative Genetic Homo sapiens
50 FBXW7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
51 HGS 9146
Affinity Capture-Western Homo sapiens
52 PPP6R1 22870
Affinity Capture-MS Homo sapiens
53 WIZ 58525
Affinity Capture-MS Homo sapiens
54 LEF1  
Reconstituted Complex Homo sapiens
55 ARMC8 25852
Affinity Capture-MS Homo sapiens
56 TAB1 10454
Affinity Capture-MS Homo sapiens
57 CST9L  
Affinity Capture-MS Homo sapiens
58 RLTPR 146206
Affinity Capture-MS Homo sapiens
59 STX6 10228
Proximity Label-MS Homo sapiens
60 IGFL3  
Affinity Capture-MS Homo sapiens
61 ANAPC7 51434
Affinity Capture-MS Homo sapiens
62 PRKDC 5591
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
63 C18orf8 29919
Affinity Capture-MS Homo sapiens
64 USP2  
Biochemical Activity Homo sapiens
65 RAB35 11021
Proximity Label-MS Homo sapiens
66 ELSPBP1  
Affinity Capture-MS Homo sapiens
67 ARIH2 10425
Affinity Capture-MS Homo sapiens
68 GPS1 2873
Affinity Capture-MS Homo sapiens
69 USP7 7874
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
70 NEDD4 4734
Affinity Capture-Western Homo sapiens
71 C9orf163  
Affinity Capture-MS Homo sapiens
72 GFI1B  
Two-hybrid Homo sapiens
73 RBPJ 3516
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
74 LAMTOR1 55004
Proximity Label-MS Homo sapiens
75 NOTCH2 4853
Affinity Capture-MS Homo sapiens
76 MAPK1 5594
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
77 RB1 5925
Affinity Capture-MS Homo sapiens
78 WNT3A 89780
Affinity Capture-MS Homo sapiens
79 PRPF6 24148
Affinity Capture-MS Homo sapiens
80 ZBTB2 57621
Affinity Capture-MS Homo sapiens
81 SRRT 51593
Affinity Capture-MS Homo sapiens
82 VAV1 7409
Affinity Capture-MS Homo sapiens
83 USP12 219333
Biochemical Activity Homo sapiens
84 PRPF8 10594
Affinity Capture-MS Homo sapiens
85 USP10 9100
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
86 CDC23 8697
Affinity Capture-MS Homo sapiens
87 USP11 8237
Affinity Capture-MS Homo sapiens
88 RFX1  
Affinity Capture-MS Homo sapiens
89 NOV 4856
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
90 TARBP2  
Affinity Capture-Western Homo sapiens
91 IGSF5  
Affinity Capture-MS Homo sapiens
92 DTX1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 LYN 4067
Proximity Label-MS Homo sapiens
94 HEY2  
Negative Genetic Homo sapiens
95 CBL 867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
96 WISP3  
Affinity Capture-MS Homo sapiens
97 MAP1LC3A 84557
Affinity Capture-Western Homo sapiens
98 FOXD4L6  
Affinity Capture-MS Homo sapiens
99 SMARCA4 6597
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
100 CDH1 999
Proximity Label-MS Homo sapiens
101 PPP2CB 5516
Affinity Capture-Western Homo sapiens
102 CNOT1 23019
Affinity Capture-MS Homo sapiens
103 NUMB 8650
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
104 DIRAS3  
Proximity Label-MS Homo sapiens
105 LRCH1 23143
Affinity Capture-MS Homo sapiens
106 NEDD4L 23327
Affinity Capture-Western Homo sapiens
107 JAG2  
Reconstituted Complex Homo sapiens
108 SMAD3 4088
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
109 CNTN1 1272
Affinity Capture-Western Homo sapiens
110 DTX2 113878
Proximity Label-MS Homo sapiens
111 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
112 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
113 MKRN2 23609
Affinity Capture-RNA Homo sapiens
114 FIGF 2277
Affinity Capture-MS Homo sapiens
115 LRBA 987
Affinity Capture-MS Homo sapiens
116 HGF 3082
Affinity Capture-MS Homo sapiens
117 SMC1A 8243
Affinity Capture-MS Homo sapiens
118 MED25  
Affinity Capture-MS Homo sapiens
119 WNT10A  
Affinity Capture-MS Homo sapiens
120 MAML3  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
121 SLFN5 162394
Affinity Capture-MS Homo sapiens
122 FANCG 2189
Affinity Capture-Western Homo sapiens
123 CDC27 996
Affinity Capture-MS Homo sapiens
124 LATS2 26524
Proximity Label-MS Homo sapiens
125 ELOVL5 60481
Proximity Label-MS Homo sapiens
126 CTDSPL 10217
Proximity Label-MS Homo sapiens
127 PDS5A 23244
Affinity Capture-MS Homo sapiens
128 TNPO1 3842
Affinity Capture-MS Homo sapiens
129 DKK2  
Affinity Capture-MS Homo sapiens
130 VPS11 55823
Affinity Capture-MS Homo sapiens
131 HCLS1 3059
Affinity Capture-MS Homo sapiens
132 SMARCC2 6601
Affinity Capture-MS Homo sapiens
133 KIF2A 3796
Affinity Capture-MS Homo sapiens
134 PPP1R12B 4660
Affinity Capture-MS Homo sapiens
135 RING1 6015
Affinity Capture-MS Homo sapiens
136 RNF40 9810
Affinity Capture-MS Homo sapiens
137 ASCC3 10973
Affinity Capture-MS Homo sapiens
138 WDR11 55717
Affinity Capture-MS Homo sapiens
139 CACNA1A  
Two-hybrid Homo sapiens
140 IPO5 3843
Affinity Capture-MS Homo sapiens
141 PSEN1 5663
Affinity Capture-Western Homo sapiens
142 SMCHD1 23347
Affinity Capture-MS Homo sapiens
143 RAB7A 7879
Affinity Capture-Western Homo sapiens
144 MARCH1  
Affinity Capture-MS Homo sapiens
145 USP15 9958
Affinity Capture-MS Homo sapiens
146 NBEA  
Affinity Capture-MS Homo sapiens
147 SMARCA5 8467
Affinity Capture-MS Homo sapiens
148 DHX15 1665
Affinity Capture-MS Homo sapiens
149 ZDHHC12  
Affinity Capture-MS Homo sapiens
150 CCT6A 908
Affinity Capture-MS Homo sapiens
151 IFI16 3428
Affinity Capture-MS Homo sapiens
152 HTATSF1 27336
Affinity Capture-MS Homo sapiens
153 LAMP1 3916
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
154 MAML1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
155 HCFC1 3054
Affinity Capture-MS Homo sapiens
156 ATP6V1D 51382
Affinity Capture-MS Homo sapiens
157 PRG2  
Affinity Capture-MS Homo sapiens
158 CUL3 8452
Affinity Capture-MS Homo sapiens
159 PTEN 5728
Synthetic Growth Defect Homo sapiens
160 CCZ1B 221960
Affinity Capture-MS Homo sapiens
161 MAP3K1 4214
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
162 ARF6 382
Proximity Label-MS Homo sapiens
163 IKZF1  
Affinity Capture-MS Homo sapiens
164 PPP6R3 55291
Affinity Capture-MS Homo sapiens
165 LIMK2 3985
Affinity Capture-MS Homo sapiens
166 SART1 9092
Affinity Capture-MS Homo sapiens
167 RUNX3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
168 RFC1 5981
Affinity Capture-MS Homo sapiens
169 YY1 7528
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
170 RANBP9 10048
Affinity Capture-MS Homo sapiens
171 FANCA  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
172 RND3 390
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
173 CAMK4 814
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
174 BCL11B  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
175 RBM10  
Affinity Capture-MS Homo sapiens
176 PRPF19 27339
Affinity Capture-MS Homo sapiens
177 IFNAR1  
Affinity Capture-MS Homo sapiens
178 XRCC6 2547
Two-hybrid Homo sapiens
179 SMAD9  
Affinity Capture-MS Homo sapiens
180 FBXO2 26232
Affinity Capture-MS Homo sapiens
181 EPN1 29924
Affinity Capture-Western Homo sapiens
182 GATAD2B 57459
Affinity Capture-MS Homo sapiens
183 KAT5  
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
184 NFKB1 4790
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
185 MED23 9439
Affinity Capture-MS Homo sapiens
186 MDN1 23195
Affinity Capture-MS Homo sapiens
187 RNF2  
Affinity Capture-MS Homo sapiens
188 RHOB 388
Proximity Label-MS Homo sapiens
189 ILK 3611
Biochemical Activity Homo sapiens
190 EDN3  
Affinity Capture-MS Homo sapiens
191 KIF3A 11127
Affinity Capture-MS Homo sapiens
192 AKT1 207
Biochemical Activity Homo sapiens
193 IKZF2 22807
Affinity Capture-MS Homo sapiens
194 WNT2  
Affinity Capture-MS Homo sapiens
195 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
196 FLOT1 10211
Proximity Label-MS Homo sapiens
197 RBBP4 5928
Affinity Capture-MS Homo sapiens
198 STUB1 10273
Affinity Capture-Western Homo sapiens
199 RELA 5970
Affinity Capture-Western Homo sapiens
200 EIF3F 8665
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
201 GSK3B 2932
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
202 CCT8 10694
Affinity Capture-MS Homo sapiens
203 PARP1 142
Affinity Capture-MS Homo sapiens
204 ROCK1 6093
Affinity Capture-MS Homo sapiens
205 SNAI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
206 FANCC 2176
Affinity Capture-Western Homo sapiens
207 ERH 2079
Affinity Capture-MS Homo sapiens
208 IKZF3  
Affinity Capture-MS Homo sapiens
209 FRYL 285527
Affinity Capture-MS Homo sapiens
210 STK38 11329
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
211 MCM5 4174
Affinity Capture-MS Homo sapiens
212 SMARCC1 6599
Affinity Capture-MS Homo sapiens
213 TRAPPC10 7109
Affinity Capture-MS Homo sapiens
214 RIF1  
Affinity Capture-MS Homo sapiens
215 FANCF  
Affinity Capture-Western Homo sapiens
216 HLTF  
Affinity Capture-MS Homo sapiens
217 LCK 3932
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
218 PTBP1 5725
Affinity Capture-MS Homo sapiens
219 SQSTM1 8878
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
220 PBRM1 55193
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
221 ITCH 83737
Affinity Capture-Western Homo sapiens
222 PTBP3 9991
Affinity Capture-MS Homo sapiens
223 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
224 CHD4 1108
Affinity Capture-MS Homo sapiens
225 Itch 16396
Affinity Capture-Western Mus musculus
226 C11orf52 91894
Proximity Label-MS Homo sapiens
227 RUNX1  
Affinity Capture-MS Homo sapiens
228 MMS19 64210
Affinity Capture-MS Homo sapiens
229 SMC3 9126
Affinity Capture-MS Homo sapiens
230 RAB5A 5868
Affinity Capture-Western Homo sapiens
231 MAU2  
Affinity Capture-MS Homo sapiens
232 XPO5 57510
Affinity Capture-MS Homo sapiens
233 TRIM37  
Proximity Label-MS Homo sapiens
234 KDM1A 23028
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
235 ABTB2 25841
Affinity Capture-MS Homo sapiens
236 RAB2A 5862
Proximity Label-MS Homo sapiens
237 NTN5  
Affinity Capture-MS Homo sapiens
238 ARRB1 408
Affinity Capture-Western Homo sapiens
239 DDR1 780
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
240 WWTR1 25937
Affinity Capture-MS Homo sapiens
241 RAB11A 8766
Proximity Label-MS Homo sapiens
242 LPAR2 9170
Affinity Capture-MS Homo sapiens
243 C14orf166 51637
Affinity Capture-MS Homo sapiens
244 EGFL7 51162
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
245 SNW1 22938
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
246 KRAS 3845
Proximity Label-MS Homo sapiens
247 RAB5C 5878
Proximity Label-MS Homo sapiens
248 VPS39 23339
Affinity Capture-MS Homo sapiens
249 MOB1A 55233
Affinity Capture-MS Homo sapiens
250 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
251 ZBED4 9889
Affinity Capture-MS Homo sapiens
252 PPP2R2A 5520
Affinity Capture-MS Homo sapiens
253 PHF8  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
254 MAML2  
Two-hybrid Homo sapiens
255 CAV1 857
Proximity Label-MS Homo sapiens
256 SIRPD  
Affinity Capture-MS Homo sapiens
257 NOTCH1 4851
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
258 EP300 2033
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
259 ARIH1 25820
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NOTCH1 is involved
PathwayEvidenceSource
Activated NOTCH1 Transmits Signal to the Nucleus IEA Reactome
Activated NOTCH1 Transmits Signal to the Nucleus TAS Reactome
Cellular response to chemical stress TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants TAS Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants TAS Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants TAS Reactome
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant TAS Reactome
Defective LFNG causes SCDO3 TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases associated with O-glycosylation of proteins TAS Reactome
Diseases of glycosylation TAS Reactome
Diseases of metabolism TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
FBXW7 Mutants and NOTCH1 in Cancer TAS Reactome
Formation of paraxial mesoderm IEA Reactome
Gastrulation IEA Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway IEA Reactome
Generic Transcription Pathway TAS Reactome
KEAP1-NFE2L2 pathway TAS Reactome
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling TAS Reactome
NFE2L2 regulating tumorigenic genes TAS Reactome
Notch-HLH transcription pathway TAS Reactome
NOTCH1 Intracellular Domain Regulates Transcription TAS Reactome
NOTCH1 Intracellular Domain Regulates Transcription IEA Reactome
NOTCH3 Intracellular Domain Regulates Transcription TAS Reactome
NOTCH3 Intracellular Domain Regulates Transcription IEA Reactome
NOTCH4 Intracellular Domain Regulates Transcription TAS Reactome
Nuclear events mediated by NFE2L2 TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Expression and Processing TAS Reactome
Pre-NOTCH Processing in Golgi TAS Reactome
Pre-NOTCH Processing in Golgi IEA Reactome
Pre-NOTCH Processing in the Endoplasmic Reticulum IEA Reactome
Pre-NOTCH Transcription and Translation TAS Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Regulation of beta-cell development IEA Reactome
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells IEA Reactome
Regulation of NFE2L2 gene expression TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RNA Polymerase II Transcription TAS Reactome
RUNX3 regulates NOTCH signaling IEA Reactome
RUNX3 regulates NOTCH signaling TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH TAS Reactome
Signaling by NOTCH1 IEA Reactome
Signaling by NOTCH1 TAS Reactome
Signaling by NOTCH1 HD Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH1 in Cancer TAS Reactome
Signaling by NOTCH1 PEST Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant TAS Reactome
Signaling by NOTCH3 TAS Reactome
Signaling by NOTCH3 IEA Reactome
Signaling by NOTCH4 TAS Reactome
Somitogenesis IEA Reactome
Transcriptional regulation by RUNX3 IEA Reactome
Transcriptional regulation by RUNX3 TAS Reactome





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