Gene description for SYT1
Gene name	synaptotagmin I
Gene symbol	SYT1
Other names/aliases	P65 SVP65 SYT
Species	Homo sapiens
Database cross references - SYT1
ExoCarta	ExoCarta_6857
Entrez Gene	6857
HGNC	11509
MIM	185605
UniProt	P21579
SYT1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable
Neuroblastoma cells	25944692

Gene ontology annotations for SYT1

Molecular Function     identical protein binding GO:0042802 IEA     protein C-terminus binding GO:0008022 IEA     protein binding GO:0005515 IPI     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IBA     low-density lipoprotein particle receptor binding GO:0050750 IDA     1-phosphatidylinositol binding GO:0005545 TAS     clathrin binding GO:0030276 IBA     calcium-dependent phospholipid binding GO:0005544 TAS     calcium ion binding GO:0005509 IBA     calcium-dependent protein binding GO:0048306 IEA     phosphatidylserine binding GO:0001786 IEA     syntaxin-1 binding GO:0017075 TAS     SNARE binding GO:0000149 ISS     calmodulin binding GO:0005516 IEA Biological Process     synaptic transmission GO:0007268 TAS     vesicle docking GO:0048278 IEA     positive regulation of calcium ion-dependent exocytosis GO:0045956 IEA     regulation of calcium ion-dependent exocytosis GO:0017158 IBA     glutamate secretion GO:0014047 TAS     regulation of regulated secretory pathway GO:1903305 ISS     regulation of synaptic transmission, glutamatergic GO:0051966 ISS     calcium ion-dependent exocytosis of neurotransmitter GO:0048791 IBA     synaptic vesicle exocytosis GO:0016079 IBA     fast, calcium ion-dependent exocytosis of neurotransmitter GO:0098746 ISS     detection of calcium ion GO:0005513 TAS     positive regulation of dendrite extension GO:1903861 IDA     positive regulation of vesicle fusion GO:0031340 IEA     protein homooligomerization GO:0051260 TAS     neurotransmitter secretion GO:0007269 TAS     regulation of exocytosis GO:0017157 TAS     positive regulation of synaptic transmission GO:0050806 ISS     synaptic vesicle endocytosis GO:0048488 IBA Subcellular Localization     chromaffin granule membrane GO:0042584 IEA     dense core granule GO:0031045 IEA     clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 TAS     neuron projection GO:0043005 ISS     presynaptic membrane GO:0042734 IEA     excitatory synapse GO:0060076 IEA     synaptic vesicle membrane GO:0030672 TAS     clathrin-sculpted glutamate transport vesicle membrane GO:0060203 TAS     clathrin-sculpted monoamine transport vesicle membrane GO:0070083 TAS     SNARE complex GO:0031201 IEA     cell junction GO:0030054 IEA     plasma membrane GO:0005886 TAS     integral component of membrane GO:0016021 IEA     synaptic vesicle GO:0008021 TAS     clathrin-sculpted acetylcholine transport vesicle membrane GO:0060201 TAS